Neurotensin inhibits AMPK activity and concurrently enhances FABP1 expression in small intestinal epithelial cells associated with obesity and aging

Neurotensin inhibits AMPK activity and concurrently enhances FABP1 expression in small intestinal epithelial cells associated with obesity and aging

Abstract We previously demonstrated that neurotensin, a 13-amino-acid gut hormone peptide, enhances small intestinal epithelial cell fatty acid uptake through inhibition of AMPK. Here, utilizing Drosophila and mouse models in vivo, as well as mouse and human small intestinal epithelial organoids or...

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Main Authors: Jing Li, Jun Song, Baoxiang Yan, Haoming Wu, Moumita Banerjee, Leif Magnuson, Yajuan Liu, Shulin Zhang, Jinpeng Liu, Chi Wang, Tianyan Gao, Jianhang Jia, Heidi L. Weiss, B. Mark Evers
Format: Article
Language:English
Published: Nature Publishing Group 2025-06-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-025-01461-w
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