Bio-engineered microRNA-7 effectively interferes with the Akt3/p53 axis to suppress human non-small cell lung cancer

Bio-engineered microRNA-7 effectively interferes with the Akt3/p53 axis to suppress human non-small cell lung cancer

Abstract Non-small cell lung cancer (NSCLC) remains the leading cause of cancer deaths worldwide. Unfortunately, effective treatment is still lacking. The p53 tumor-suppressor protein is a critical mediator of cellular growth arrest and apoptosis, and is closely related to NSCLC. Importantly, microR...

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Bibliographic Details
Main Authors: Qian Huang, Xiaohua Chu, Chaofei Yang, Ying Huai, Chenyang He, Xingcong Ma, Jiawei Pei, Junhong Gao, Zhiyong Liu, Shanfeng Jiang, Airong Qian, Ye Tian
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cancer Cell International
Subjects:
Carcinoma, non-small-cell lung
Bio-engineered RNA
miR-7
Akt3
p53
Online Access:https://doi.org/10.1186/s12935-025-03856-1
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