A quantitative multi-parameter mapping protocol standardized for clinical research in multiple sclerosis
Abstract Quantitative magnetic resonance imaging (qMRI) involves mapping microstructure in standardized units sensitive to histological properties and supplements conventional MRI, which relies on contrast weighted images where intensities have no biophysical meaning. While measuring tissue properti...
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Nature Portfolio
2024-12-01
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| Online Access: | https://doi.org/10.1038/s41598-024-80274-9 |
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| author | Henri Trang Tim J. Hartung Qianlan Chen Stefan Hetzer Claudia Chien Pia S. Sperber Tanja Schmitz-Hübsch Susanna Asseyer Rebekka Rust Darius Mewes Lina Anderhalten Michael Sy Alexander U. Brandt Carsten Finke Friedemann Paul |
| author_facet | Henri Trang Tim J. Hartung Qianlan Chen Stefan Hetzer Claudia Chien Pia S. Sperber Tanja Schmitz-Hübsch Susanna Asseyer Rebekka Rust Darius Mewes Lina Anderhalten Michael Sy Alexander U. Brandt Carsten Finke Friedemann Paul |
| author_sort | Henri Trang |
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| description | Abstract Quantitative magnetic resonance imaging (qMRI) involves mapping microstructure in standardized units sensitive to histological properties and supplements conventional MRI, which relies on contrast weighted images where intensities have no biophysical meaning. While measuring tissue properties such as myelin, iron or water content is desired in a disease context, qMRI changes may typically reflect mixed influences from aging or pre-clinical degeneration. We used a fast multi-parameter mapping (MPM) protocol for clinical routine at 3T to reconstruct whole-brain quantitative maps of magnetization transfer saturation (MT), proton density (PD), longitudinal (R1), and transverse relaxation rate (R2*) with 1.6 mm isotropic resolution. We report reference MPM values from a healthy population with age and gender distributions typical of multiple sclerosis in whole brain white matter (WM), T2-weighted WM hyperintensities, cortical grey matter and deep grey matter regions and present post-processing optimizations including integration of lesions and normalization of PD maps against cerebrospinal fluid (CSF) for standardized research in multiple sclerosis (MS) and potentially also in related disorders. PD maps were affected by WM abnormalities in MS using WM calibration. The results acknowledge the impact of non-linear age effects on MPM and suggest using CSF calibration for future clinical application in MS. |
| format | Article |
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| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
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| spelling | doaj-art-ba22e0d189fb4cf9994eec6ae93779ae2025-08-20T01:59:48ZengNature PortfolioScientific Reports2045-23222024-12-0114111710.1038/s41598-024-80274-9A quantitative multi-parameter mapping protocol standardized for clinical research in multiple sclerosisHenri Trang0Tim J. Hartung1Qianlan Chen2Stefan Hetzer3Claudia Chien4Pia S. Sperber5Tanja Schmitz-Hübsch6Susanna Asseyer7Rebekka Rust8Darius Mewes9Lina Anderhalten10Michael Sy11Alexander U. Brandt12Carsten Finke13Friedemann Paul14Experimental and Clinical Research Center, a Cooperation Between Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Charité – Universitätsmedizin BerlinDepartment of Neurology and Experimental Neurology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu BerlinExperimental and Clinical Research Center, a Cooperation Between Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Charité – Universitätsmedizin BerlinBerlin Center for Advanced Neuroimaging, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of HealthExperimental and Clinical Research Center, a Cooperation Between Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Charité – Universitätsmedizin BerlinExperimental and Clinical Research Center, a Cooperation Between Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Charité – Universitätsmedizin BerlinExperimental and Clinical Research Center, a Cooperation Between Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Charité – Universitätsmedizin BerlinExperimental and Clinical Research Center, a Cooperation Between Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Charité – Universitätsmedizin BerlinExperimental and Clinical Research Center, a Cooperation Between Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Charité – Universitätsmedizin BerlinExperimental and Clinical Research Center, a Cooperation Between Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Charité – Universitätsmedizin BerlinExperimental and Clinical Research Center, a Cooperation Between Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Charité – Universitätsmedizin BerlinDepartment of Neurology, University of California IrvineExperimental and Clinical Research Center, a Cooperation Between Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Charité – Universitätsmedizin BerlinDepartment of Neurology and Experimental Neurology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu BerlinExperimental and Clinical Research Center, a Cooperation Between Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Charité – Universitätsmedizin BerlinAbstract Quantitative magnetic resonance imaging (qMRI) involves mapping microstructure in standardized units sensitive to histological properties and supplements conventional MRI, which relies on contrast weighted images where intensities have no biophysical meaning. While measuring tissue properties such as myelin, iron or water content is desired in a disease context, qMRI changes may typically reflect mixed influences from aging or pre-clinical degeneration. We used a fast multi-parameter mapping (MPM) protocol for clinical routine at 3T to reconstruct whole-brain quantitative maps of magnetization transfer saturation (MT), proton density (PD), longitudinal (R1), and transverse relaxation rate (R2*) with 1.6 mm isotropic resolution. We report reference MPM values from a healthy population with age and gender distributions typical of multiple sclerosis in whole brain white matter (WM), T2-weighted WM hyperintensities, cortical grey matter and deep grey matter regions and present post-processing optimizations including integration of lesions and normalization of PD maps against cerebrospinal fluid (CSF) for standardized research in multiple sclerosis (MS) and potentially also in related disorders. PD maps were affected by WM abnormalities in MS using WM calibration. The results acknowledge the impact of non-linear age effects on MPM and suggest using CSF calibration for future clinical application in MS.https://doi.org/10.1038/s41598-024-80274-9Quantitative MRIMulti-parameter mappingNeuroimagingMultiple sclerosisAgingProton density |
| spellingShingle | Henri Trang Tim J. Hartung Qianlan Chen Stefan Hetzer Claudia Chien Pia S. Sperber Tanja Schmitz-Hübsch Susanna Asseyer Rebekka Rust Darius Mewes Lina Anderhalten Michael Sy Alexander U. Brandt Carsten Finke Friedemann Paul A quantitative multi-parameter mapping protocol standardized for clinical research in multiple sclerosis Scientific Reports Quantitative MRI Multi-parameter mapping Neuroimaging Multiple sclerosis Aging Proton density |
| title | A quantitative multi-parameter mapping protocol standardized for clinical research in multiple sclerosis |
| title_full | A quantitative multi-parameter mapping protocol standardized for clinical research in multiple sclerosis |
| title_fullStr | A quantitative multi-parameter mapping protocol standardized for clinical research in multiple sclerosis |
| title_full_unstemmed | A quantitative multi-parameter mapping protocol standardized for clinical research in multiple sclerosis |
| title_short | A quantitative multi-parameter mapping protocol standardized for clinical research in multiple sclerosis |
| title_sort | quantitative multi parameter mapping protocol standardized for clinical research in multiple sclerosis |
| topic | Quantitative MRI Multi-parameter mapping Neuroimaging Multiple sclerosis Aging Proton density |
| url | https://doi.org/10.1038/s41598-024-80274-9 |
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