Immunotherapy resistance in solid tumors: mechanisms and potential solutions
While the emergence of immunotherapies has fundamentally altered the management of solid tumors, cancers exploit many complex biological mechanisms that result in resistance to these agents. These encompass a broad range of cellular activities – from modification of traditional paradigms of immunity...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Cancer Biology & Therapy |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15384047.2024.2315655 |
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| author | Daniel S. Lefler Steven A. Manobianco Babar Bashir |
| author_facet | Daniel S. Lefler Steven A. Manobianco Babar Bashir |
| author_sort | Daniel S. Lefler |
| collection | DOAJ |
| description | While the emergence of immunotherapies has fundamentally altered the management of solid tumors, cancers exploit many complex biological mechanisms that result in resistance to these agents. These encompass a broad range of cellular activities – from modification of traditional paradigms of immunity via antigen presentation and immunoregulation to metabolic modifications and manipulation of the tumor microenvironment. Intervening on these intricate processes may provide clinical benefit in patients with solid tumors by overcoming resistance to immunotherapies, which is why it has become an area of tremendous research interest with practice-changing implications. This review details the major ways cancers avoid both natural immunity and immunotherapies through primary (innate) and secondary (acquired) mechanisms of resistance, and it considers available and emerging therapeutic approaches to overcoming immunotherapy resistance. |
| format | Article |
| id | doaj-art-ba2082a83f7d41ecb8d13b09d322499e |
| institution | OA Journals |
| issn | 1538-4047 1555-8576 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cancer Biology & Therapy |
| spelling | doaj-art-ba2082a83f7d41ecb8d13b09d322499e2025-08-20T01:58:48ZengTaylor & Francis GroupCancer Biology & Therapy1538-40471555-85762024-12-0125110.1080/15384047.2024.2315655Immunotherapy resistance in solid tumors: mechanisms and potential solutionsDaniel S. Lefler0Steven A. Manobianco1Babar Bashir2Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USADepartment of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USADepartment of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USAWhile the emergence of immunotherapies has fundamentally altered the management of solid tumors, cancers exploit many complex biological mechanisms that result in resistance to these agents. These encompass a broad range of cellular activities – from modification of traditional paradigms of immunity via antigen presentation and immunoregulation to metabolic modifications and manipulation of the tumor microenvironment. Intervening on these intricate processes may provide clinical benefit in patients with solid tumors by overcoming resistance to immunotherapies, which is why it has become an area of tremendous research interest with practice-changing implications. This review details the major ways cancers avoid both natural immunity and immunotherapies through primary (innate) and secondary (acquired) mechanisms of resistance, and it considers available and emerging therapeutic approaches to overcoming immunotherapy resistance.https://www.tandfonline.com/doi/10.1080/15384047.2024.2315655Immunoresistancecancer treatmentimmune checkpoint inhibitorscytokinestumor microenvironment |
| spellingShingle | Daniel S. Lefler Steven A. Manobianco Babar Bashir Immunotherapy resistance in solid tumors: mechanisms and potential solutions Cancer Biology & Therapy Immunoresistance cancer treatment immune checkpoint inhibitors cytokines tumor microenvironment |
| title | Immunotherapy resistance in solid tumors: mechanisms and potential solutions |
| title_full | Immunotherapy resistance in solid tumors: mechanisms and potential solutions |
| title_fullStr | Immunotherapy resistance in solid tumors: mechanisms and potential solutions |
| title_full_unstemmed | Immunotherapy resistance in solid tumors: mechanisms and potential solutions |
| title_short | Immunotherapy resistance in solid tumors: mechanisms and potential solutions |
| title_sort | immunotherapy resistance in solid tumors mechanisms and potential solutions |
| topic | Immunoresistance cancer treatment immune checkpoint inhibitors cytokines tumor microenvironment |
| url | https://www.tandfonline.com/doi/10.1080/15384047.2024.2315655 |
| work_keys_str_mv | AT danielslefler immunotherapyresistanceinsolidtumorsmechanismsandpotentialsolutions AT stevenamanobianco immunotherapyresistanceinsolidtumorsmechanismsandpotentialsolutions AT babarbashir immunotherapyresistanceinsolidtumorsmechanismsandpotentialsolutions |