Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus
Aim. To assess the efficacy and safety of accelerated corneal cross-linking in the treatment of pediatric keratoconus. Method. In this retrospective case series, 29 eyes of 20 pediatric patients with keratoconus underwent accelerated corneal cross-linking. Treatment was delivered at 10 mW/cm2 for 9...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2021/1851883 |
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| author | Abdelrahman Salman Taym Darwish Marwan Ghabra Obeda Kailani Hussam Khalil Rafea Shaaban |
| author_facet | Abdelrahman Salman Taym Darwish Marwan Ghabra Obeda Kailani Hussam Khalil Rafea Shaaban |
| author_sort | Abdelrahman Salman |
| collection | DOAJ |
| description | Aim. To assess the efficacy and safety of accelerated corneal cross-linking in the treatment of pediatric keratoconus. Method. In this retrospective case series, 29 eyes of 20 pediatric patients with keratoconus underwent accelerated corneal cross-linking. Treatment was delivered at 10 mW/cm2 for 9 minutes with a total dose of 5.4 J/cm2. Clinical evaluation included visual acuities and refractive and Scheimpflug corneal tomography assessments. All patients with a minimum follow-up duration of 24 months were included in the study. Results. Mean ± standard deviation age was 15.41 ± 2.13 years (range: 8 to 18 years). Uncorrected distance visual acuity improved significantly from 0.56 ± 0.28 to 0.42 ± 0.29 logMAR P=0.0003, and corrected distance visual acuity improved significantly from 0.34 ± 0.23 to 0.28 ± 0.22 logMAR P=0.014. The mean manifest refraction spherical equivalent value was significantly reduced (−0.59 ± 0.95 D, P=0.0024). While mean flat keratometry and steep keratometry values were not significantly altered (P>0.05 for both), the mean maximum keratometry value was significantly decreased from 56.97 ± 5.24 D preoperatively to 55.84 ± 5.37 D at 24 months postoperatively P=0.003. Maximum keratometry had progressed by >1 D in two eyes (6.89%). Permanent corneal haze was reported in one case (3.44%). Conclusion. Our 24-month follow-up demonstrated that accelerated corneal cross-linking appears to halt the progression of keratoconus in pediatric patients without apparent complications. Uncorrected and corrected distance visual acuities were also improved. |
| format | Article |
| id | doaj-art-ba1f4d961a004efd89ba46948160b076 |
| institution | Kabale University |
| issn | 2090-0058 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-ba1f4d961a004efd89ba46948160b0762025-02-03T06:43:37ZengWileyJournal of Ophthalmology2090-00582021-01-01202110.1155/2021/1851883Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric KeratoconusAbdelrahman Salman0Taym Darwish1Marwan Ghabra2Obeda Kailani3Hussam Khalil4Rafea Shaaban5Honorary Clinical Lecturer at Tishreen UniversityHead of Department of OphthalmologyWhipps Cross University HospitalAKC FRCOphth CertLRS Queen Mary’s HospitalSurgical Eye HospitalTartous UniversityAim. To assess the efficacy and safety of accelerated corneal cross-linking in the treatment of pediatric keratoconus. Method. In this retrospective case series, 29 eyes of 20 pediatric patients with keratoconus underwent accelerated corneal cross-linking. Treatment was delivered at 10 mW/cm2 for 9 minutes with a total dose of 5.4 J/cm2. Clinical evaluation included visual acuities and refractive and Scheimpflug corneal tomography assessments. All patients with a minimum follow-up duration of 24 months were included in the study. Results. Mean ± standard deviation age was 15.41 ± 2.13 years (range: 8 to 18 years). Uncorrected distance visual acuity improved significantly from 0.56 ± 0.28 to 0.42 ± 0.29 logMAR P=0.0003, and corrected distance visual acuity improved significantly from 0.34 ± 0.23 to 0.28 ± 0.22 logMAR P=0.014. The mean manifest refraction spherical equivalent value was significantly reduced (−0.59 ± 0.95 D, P=0.0024). While mean flat keratometry and steep keratometry values were not significantly altered (P>0.05 for both), the mean maximum keratometry value was significantly decreased from 56.97 ± 5.24 D preoperatively to 55.84 ± 5.37 D at 24 months postoperatively P=0.003. Maximum keratometry had progressed by >1 D in two eyes (6.89%). Permanent corneal haze was reported in one case (3.44%). Conclusion. Our 24-month follow-up demonstrated that accelerated corneal cross-linking appears to halt the progression of keratoconus in pediatric patients without apparent complications. Uncorrected and corrected distance visual acuities were also improved.http://dx.doi.org/10.1155/2021/1851883 |
| spellingShingle | Abdelrahman Salman Taym Darwish Marwan Ghabra Obeda Kailani Hussam Khalil Rafea Shaaban Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus Journal of Ophthalmology |
| title | Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus |
| title_full | Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus |
| title_fullStr | Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus |
| title_full_unstemmed | Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus |
| title_short | Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus |
| title_sort | clinical outcomes of accelerated corneal cross linking for pediatric keratoconus |
| url | http://dx.doi.org/10.1155/2021/1851883 |
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