Resveratrol Contrasts LPA-Induced Ovarian Cancer Cell Migration and Platinum Resistance by Rescuing Hedgehog-Mediated Autophagy

Resveratrol Contrasts LPA-Induced Ovarian Cancer Cell Migration and Platinum Resistance by Rescuing Hedgehog-Mediated Autophagy

<b>Background</b>: Ovarian cancer progression and invasiveness are promoted by a range of soluble factors released by cancer cells and stromal cells within the tumor microenvironment. Our previous studies demonstrated that resveratrol (RV), a nutraceutical and caloric restriction mimetic...

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Main Authors: Alessandra Ferraresi, Andrea Esposito, Carlo Girone, Letizia Vallino, Amreen Salwa, Ian Ghezzi, Suyanee Thongchot, Chiara Vidoni, Danny N. Dhanasekaran, Ciro Isidoro
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cells
Subjects:
autophagy
tumor microenvironment
cell migration
epithelial to mesenchymal transition
BMI-1
3D spheroids
Online Access:https://www.mdpi.com/2073-4409/10/11/3213
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