Ginger and Its Constituents: Role in Prevention and Treatment of Gastrointestinal Cancer
Gastrointestinal (GI) cancer, a cancer of different organs of the digestive system, is one of the most common cancers around the world. The incidence and death rate of some of these cancers are very high. Although a large variety of chemotherapeutic agents have been introduced since the last few dec...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/142979 |
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| author | Sahdeo Prasad Amit K. Tyagi |
| author_facet | Sahdeo Prasad Amit K. Tyagi |
| author_sort | Sahdeo Prasad |
| collection | DOAJ |
| description | Gastrointestinal (GI) cancer, a cancer of different organs of the digestive system, is one of the most common cancers around the world. The incidence and death rate of some of these cancers are very high. Although a large variety of chemotherapeutic agents have been introduced since the last few decades to combat GI cancer, most of them are very expensive and have side effects. Therefore, the compounds derived from natural sources, which are considered to be safe and cost effective, are needed. Ginger (Zingiber officinale) is one of the most widely used natural products consumed as a spice and medicine for treating nausea, dysentery, heartburn, flatulence, diarrhea, loss of appetite, infections, cough, and bronchitis. Experimental studies showed that ginger and its active components including 6-gingerol and 6-shogaol exert anticancer activities against GI cancer. The anticancer activity of ginger is attributed to its ability to modulate several signaling molecules like NF-κB, STAT3, MAPK, PI3K, ERK1/2, Akt, TNF-α, COX-2, cyclin D1, cdk, MMP-9, survivin, cIAP-1, XIAP, Bcl-2, caspases, and other cell growth regulatory proteins. In this review, the evidences for the chemopreventive and chemotherapeutic potential of ginger extract and its active components using in vitro, animal models, and patients have been described. |
| format | Article |
| id | doaj-art-ba19a2f7dd5040f688cbcfcfde0da39c |
| institution | DOAJ |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-ba19a2f7dd5040f688cbcfcfde0da39c2025-08-20T03:23:22ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/142979142979Ginger and Its Constituents: Role in Prevention and Treatment of Gastrointestinal CancerSahdeo Prasad0Amit K. Tyagi1Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USACytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAGastrointestinal (GI) cancer, a cancer of different organs of the digestive system, is one of the most common cancers around the world. The incidence and death rate of some of these cancers are very high. Although a large variety of chemotherapeutic agents have been introduced since the last few decades to combat GI cancer, most of them are very expensive and have side effects. Therefore, the compounds derived from natural sources, which are considered to be safe and cost effective, are needed. Ginger (Zingiber officinale) is one of the most widely used natural products consumed as a spice and medicine for treating nausea, dysentery, heartburn, flatulence, diarrhea, loss of appetite, infections, cough, and bronchitis. Experimental studies showed that ginger and its active components including 6-gingerol and 6-shogaol exert anticancer activities against GI cancer. The anticancer activity of ginger is attributed to its ability to modulate several signaling molecules like NF-κB, STAT3, MAPK, PI3K, ERK1/2, Akt, TNF-α, COX-2, cyclin D1, cdk, MMP-9, survivin, cIAP-1, XIAP, Bcl-2, caspases, and other cell growth regulatory proteins. In this review, the evidences for the chemopreventive and chemotherapeutic potential of ginger extract and its active components using in vitro, animal models, and patients have been described.http://dx.doi.org/10.1155/2015/142979 |
| spellingShingle | Sahdeo Prasad Amit K. Tyagi Ginger and Its Constituents: Role in Prevention and Treatment of Gastrointestinal Cancer Gastroenterology Research and Practice |
| title | Ginger and Its Constituents: Role in Prevention and Treatment of Gastrointestinal Cancer |
| title_full | Ginger and Its Constituents: Role in Prevention and Treatment of Gastrointestinal Cancer |
| title_fullStr | Ginger and Its Constituents: Role in Prevention and Treatment of Gastrointestinal Cancer |
| title_full_unstemmed | Ginger and Its Constituents: Role in Prevention and Treatment of Gastrointestinal Cancer |
| title_short | Ginger and Its Constituents: Role in Prevention and Treatment of Gastrointestinal Cancer |
| title_sort | ginger and its constituents role in prevention and treatment of gastrointestinal cancer |
| url | http://dx.doi.org/10.1155/2015/142979 |
| work_keys_str_mv | AT sahdeoprasad gingeranditsconstituentsroleinpreventionandtreatmentofgastrointestinalcancer AT amitktyagi gingeranditsconstituentsroleinpreventionandtreatmentofgastrointestinalcancer |