Research Progress of Osteoarthritis Treatment by Low Intensity Pulsed Ultrasound
ABSTRACT With the intensification of global population aging, osteoarthritis (OA) has emerged as a major socioeconomic burden requiring urgent therapeutic interventions. Low‐intensity pulsed ultrasound (LIPUS), a non‐invasive physical therapy modality, delivers pulsed acoustic energy to target tissu...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-06-01
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| Series: | Smart Medicine |
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| Online Access: | https://doi.org/10.1002/smmd.70003 |
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| author | Mengtong Guan Xinyu Zhang Xinhe Li Bo Liao Wang Han Jindong Tan Zijie Wang Lichen Wang Jieliang Shen Xiaoyu Han Dingqun Bai |
| author_facet | Mengtong Guan Xinyu Zhang Xinhe Li Bo Liao Wang Han Jindong Tan Zijie Wang Lichen Wang Jieliang Shen Xiaoyu Han Dingqun Bai |
| author_sort | Mengtong Guan |
| collection | DOAJ |
| description | ABSTRACT With the intensification of global population aging, osteoarthritis (OA) has emerged as a major socioeconomic burden requiring urgent therapeutic interventions. Low‐intensity pulsed ultrasound (LIPUS), a non‐invasive physical therapy modality, delivers pulsed acoustic energy to target tissues with negligible thermal effects. Accumulating evidence from preclinical studies and randomized controlled trials has demonstrated its potential to decelerate OA progression. This systematic review synthesizes current knowledge on LIPUS‐mediated OA management, elucidates mechanistic pathways through biomechanical and molecular analyses, strategies combining LIPUS with biomaterials to improve its efficacy, evaluates clinical translation challenges, and proposes standardized treatment protocols to optimize therapeutic outcomes. |
| format | Article |
| id | doaj-art-ba193c4ef3b54af5aea5c145dd0dbd34 |
| institution | OA Journals |
| issn | 2751-1871 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Smart Medicine |
| spelling | doaj-art-ba193c4ef3b54af5aea5c145dd0dbd342025-08-20T02:22:02ZengWiley-VCHSmart Medicine2751-18712025-06-0142n/an/a10.1002/smmd.70003Research Progress of Osteoarthritis Treatment by Low Intensity Pulsed UltrasoundMengtong Guan0Xinyu Zhang1Xinhe Li2Bo Liao3Wang Han4Jindong Tan5Zijie Wang6Lichen Wang7Jieliang Shen8Xiaoyu Han9Dingqun Bai10Department of Rehabilitation Medicine Key Laboratory of Physical Medicine and Precision Rehabilitation of Chongqing Municipal Health Commission The First Affiliated Hospital of Chongqing Medical University Chongqing ChinaDepartment of Rehabilitation Medicine Key Laboratory of Physical Medicine and Precision Rehabilitation of Chongqing Municipal Health Commission The First Affiliated Hospital of Chongqing Medical University Chongqing ChinaDepartment of Rehabilitation Medicine Key Laboratory of Physical Medicine and Precision Rehabilitation of Chongqing Municipal Health Commission The First Affiliated Hospital of Chongqing Medical University Chongqing ChinaDepartment of Rehabilitation Medicine Key Laboratory of Physical Medicine and Precision Rehabilitation of Chongqing Municipal Health Commission The First Affiliated Hospital of Chongqing Medical University Chongqing ChinaDepartment of Rehabilitation Medicine Key Laboratory of Physical Medicine and Precision Rehabilitation of Chongqing Municipal Health Commission The First Affiliated Hospital of Chongqing Medical University Chongqing ChinaDepartment of Rehabilitation Medicine Key Laboratory of Physical Medicine and Precision Rehabilitation of Chongqing Municipal Health Commission The First Affiliated Hospital of Chongqing Medical University Chongqing ChinaDepartment of Rehabilitation Medicine Key Laboratory of Physical Medicine and Precision Rehabilitation of Chongqing Municipal Health Commission The First Affiliated Hospital of Chongqing Medical University Chongqing ChinaStevens Institute of Technology Hoboken New Jersey USADepartment of Rehabilitation Medicine Bishan Hospital of Chongqing Medical University Chongqing ChinaDepartment of Rehabilitation Medicine Key Laboratory of Physical Medicine and Precision Rehabilitation of Chongqing Municipal Health Commission The First Affiliated Hospital of Chongqing Medical University Chongqing ChinaDepartment of Rehabilitation Medicine Key Laboratory of Physical Medicine and Precision Rehabilitation of Chongqing Municipal Health Commission The First Affiliated Hospital of Chongqing Medical University Chongqing ChinaABSTRACT With the intensification of global population aging, osteoarthritis (OA) has emerged as a major socioeconomic burden requiring urgent therapeutic interventions. Low‐intensity pulsed ultrasound (LIPUS), a non‐invasive physical therapy modality, delivers pulsed acoustic energy to target tissues with negligible thermal effects. Accumulating evidence from preclinical studies and randomized controlled trials has demonstrated its potential to decelerate OA progression. This systematic review synthesizes current knowledge on LIPUS‐mediated OA management, elucidates mechanistic pathways through biomechanical and molecular analyses, strategies combining LIPUS with biomaterials to improve its efficacy, evaluates clinical translation challenges, and proposes standardized treatment protocols to optimize therapeutic outcomes.https://doi.org/10.1002/smmd.70003combination therapylow intensity pulsed ultrasoundosteoarthritistreatment mechanism |
| spellingShingle | Mengtong Guan Xinyu Zhang Xinhe Li Bo Liao Wang Han Jindong Tan Zijie Wang Lichen Wang Jieliang Shen Xiaoyu Han Dingqun Bai Research Progress of Osteoarthritis Treatment by Low Intensity Pulsed Ultrasound Smart Medicine combination therapy low intensity pulsed ultrasound osteoarthritis treatment mechanism |
| title | Research Progress of Osteoarthritis Treatment by Low Intensity Pulsed Ultrasound |
| title_full | Research Progress of Osteoarthritis Treatment by Low Intensity Pulsed Ultrasound |
| title_fullStr | Research Progress of Osteoarthritis Treatment by Low Intensity Pulsed Ultrasound |
| title_full_unstemmed | Research Progress of Osteoarthritis Treatment by Low Intensity Pulsed Ultrasound |
| title_short | Research Progress of Osteoarthritis Treatment by Low Intensity Pulsed Ultrasound |
| title_sort | research progress of osteoarthritis treatment by low intensity pulsed ultrasound |
| topic | combination therapy low intensity pulsed ultrasound osteoarthritis treatment mechanism |
| url | https://doi.org/10.1002/smmd.70003 |
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