Biochemical effect of curcumin on hyperlipidemia induced in rats
This study was performed to investigate the effect of oral supplementation of curcumin, garlic extract and olive oil on lipid profile, nitric oxide, adiponectin, endothelin-1, blood glucose and some inflammatory markers in normal, diabetic and hyperlipidemic rats supplementing high fat and cholester...
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| Format: | Article |
| Language: | English |
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Asociaţia Naţională a Fabricanţilor de Produse de Uz Veterinar
2016-06-01
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| Series: | Medicamentul Veterinar |
| Online Access: | http://www.veterinarypharmacon.com/docs/1654-2016_VD_10(1)_Art.4.Eng.pdf |
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| author | Omayma A.R., Ragab A. Abdel-Majeed A.D Hassanin K.M. Abdelghaffar M.M. |
| author_facet | Omayma A.R., Ragab A. Abdel-Majeed A.D Hassanin K.M. Abdelghaffar M.M. |
| author_sort | Omayma A.R., |
| collection | DOAJ |
| description | This study was performed to investigate the effect of oral supplementation of curcumin, garlic extract and olive oil on lipid profile, nitric oxide, adiponectin, endothelin-1, blood glucose and some inflammatory markers in normal, diabetic and hyperlipidemic rats supplementing high fat and cholesterol-enriched diet. Forty female adult albino rats were divided into four equal groups of 10 rats each. Group (1): negative control received normal diet only, group (2): rats fed on normal diet and received curcumin orally, group (3): positive control received hyperlipidemic diet, group (4): rats fed on hyperlipidemic diet and received
curcumin (350 mg/ 1 kg b.w.) orally. The obtained results revealed that, curcumin supplementations to hyperlipidemic rats showed a significant increase in serum HDL-cholesterol, nitric oxide, adiponectin and Endothelin-1 concentrations and significantly decrease in serum total cholesterol, triacylglycerols, LDL cholesterol, Fasting blood glucose, Glycated Hemoglobin (HbA1C), high sensitive C-reactive protein and Interleukin-6 levels. These results suggest that, curcumin supplementations may have some benefits in patients suffering from dyslipidemia and diabetes. |
| format | Article |
| id | doaj-art-ba17afc33e6d492b86bada66c17ad7a3 |
| institution | DOAJ |
| issn | 1843-9527 2069-2463 |
| language | English |
| publishDate | 2016-06-01 |
| publisher | Asociaţia Naţională a Fabricanţilor de Produse de Uz Veterinar |
| record_format | Article |
| series | Medicamentul Veterinar |
| spelling | doaj-art-ba17afc33e6d492b86bada66c17ad7a32025-08-20T02:51:23ZengAsociaţia Naţională a Fabricanţilor de Produse de Uz VeterinarMedicamentul Veterinar1843-95272069-24632016-06-011014953Biochemical effect of curcumin on hyperlipidemia induced in ratsOmayma A.R., 0Ragab A.1Abdel-Majeed A.D2Hassanin K.M.3Abdelghaffar M.M.4Biochemistry department, Faculty of Veterinary Medicine, Benha University, EgyptBiochemistry department, Faculty of Veterinary Medicine, Benha University, EgyptBiochemistry department, Faculty of Veterinary Medicine, Benha University, EgyptBiochemistry department, Faculty of Veterinary Medicine, Beni-Suef University, Egypt. Biochemistry department, Faculty of Veterinary Medicine, Benha University, EgyptThis study was performed to investigate the effect of oral supplementation of curcumin, garlic extract and olive oil on lipid profile, nitric oxide, adiponectin, endothelin-1, blood glucose and some inflammatory markers in normal, diabetic and hyperlipidemic rats supplementing high fat and cholesterol-enriched diet. Forty female adult albino rats were divided into four equal groups of 10 rats each. Group (1): negative control received normal diet only, group (2): rats fed on normal diet and received curcumin orally, group (3): positive control received hyperlipidemic diet, group (4): rats fed on hyperlipidemic diet and received curcumin (350 mg/ 1 kg b.w.) orally. The obtained results revealed that, curcumin supplementations to hyperlipidemic rats showed a significant increase in serum HDL-cholesterol, nitric oxide, adiponectin and Endothelin-1 concentrations and significantly decrease in serum total cholesterol, triacylglycerols, LDL cholesterol, Fasting blood glucose, Glycated Hemoglobin (HbA1C), high sensitive C-reactive protein and Interleukin-6 levels. These results suggest that, curcumin supplementations may have some benefits in patients suffering from dyslipidemia and diabetes.http://www.veterinarypharmacon.com/docs/1654-2016_VD_10(1)_Art.4.Eng.pdf |
| spellingShingle | Omayma A.R., Ragab A. Abdel-Majeed A.D Hassanin K.M. Abdelghaffar M.M. Biochemical effect of curcumin on hyperlipidemia induced in rats Medicamentul Veterinar |
| title | Biochemical effect of curcumin on hyperlipidemia induced in rats |
| title_full | Biochemical effect of curcumin on hyperlipidemia induced in rats |
| title_fullStr | Biochemical effect of curcumin on hyperlipidemia induced in rats |
| title_full_unstemmed | Biochemical effect of curcumin on hyperlipidemia induced in rats |
| title_short | Biochemical effect of curcumin on hyperlipidemia induced in rats |
| title_sort | biochemical effect of curcumin on hyperlipidemia induced in rats |
| url | http://www.veterinarypharmacon.com/docs/1654-2016_VD_10(1)_Art.4.Eng.pdf |
| work_keys_str_mv | AT omaymaar biochemicaleffectofcurcuminonhyperlipidemiainducedinrats AT ragaba biochemicaleffectofcurcuminonhyperlipidemiainducedinrats AT abdelmajeedad biochemicaleffectofcurcuminonhyperlipidemiainducedinrats AT hassaninkm biochemicaleffectofcurcuminonhyperlipidemiainducedinrats AT abdelghaffarmm biochemicaleffectofcurcuminonhyperlipidemiainducedinrats |