Biochemical effect of curcumin on hyperlipidemia induced in rats
This study was performed to investigate the effect of oral supplementation of curcumin, garlic extract and olive oil on lipid profile, nitric oxide, adiponectin, endothelin-1, blood glucose and some inflammatory markers in normal, diabetic and hyperlipidemic rats supplementing high fat and cholester...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Asociaţia Naţională a Fabricanţilor de Produse de Uz Veterinar
2016-06-01
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| Series: | Medicamentul Veterinar |
| Online Access: | http://www.veterinarypharmacon.com/docs/1654-2016_VD_10(1)_Art.4.Eng.pdf |
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| Summary: | This study was performed to investigate the effect of oral supplementation of curcumin, garlic extract and olive oil on lipid profile, nitric oxide, adiponectin, endothelin-1, blood glucose and some inflammatory markers in normal, diabetic and hyperlipidemic rats supplementing high fat and cholesterol-enriched diet. Forty female adult albino rats were divided into four equal groups of 10 rats each. Group (1): negative control received normal diet only, group (2): rats fed on normal diet and received curcumin orally, group (3): positive control received hyperlipidemic diet, group (4): rats fed on hyperlipidemic diet and received
curcumin (350 mg/ 1 kg b.w.) orally. The obtained results revealed that, curcumin supplementations to hyperlipidemic rats showed a significant increase in serum HDL-cholesterol, nitric oxide, adiponectin and Endothelin-1 concentrations and significantly decrease in serum total cholesterol, triacylglycerols, LDL cholesterol, Fasting blood glucose, Glycated Hemoglobin (HbA1C), high sensitive C-reactive protein and Interleukin-6 levels. These results suggest that, curcumin supplementations may have some benefits in patients suffering from dyslipidemia and diabetes. |
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| ISSN: | 1843-9527 2069-2463 |