Associations of systemic immune-inflammation index and systemic inflammation response index with maternal gestational diabetes mellitus: Evidence from a prospective birth cohort study
Abstract. Background:. The role of inflammation in the development of gestational diabetes mellitus (GDM) has recently become a focus of research. The systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI), novel indices, reflect the body’s chronic immune-inflammat...
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Wolters Kluwer
2025-03-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000003236 |
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| author | Shuanghua Xie Enjie Zhang Shen Gao Shaofei Su Jianhui Liu Yue Zhang Yingyi Luan Kaikun Huang Minhui Hu Xueran Wang Hao Xing Ruixia Liu Wentao Yue Chenghong Yin Jinjiao Li |
| author_facet | Shuanghua Xie Enjie Zhang Shen Gao Shaofei Su Jianhui Liu Yue Zhang Yingyi Luan Kaikun Huang Minhui Hu Xueran Wang Hao Xing Ruixia Liu Wentao Yue Chenghong Yin Jinjiao Li |
| author_sort | Shuanghua Xie |
| collection | DOAJ |
| description | Abstract.
Background:. The role of inflammation in the development of gestational diabetes mellitus (GDM) has recently become a focus of research. The systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI), novel indices, reflect the body’s chronic immune-inflammatory state. This study aimed to investigate the associations between the SII or SIRI and GDM.
Methods:. A prospective birth cohort study was conducted at Beijing Obstetrics and Gynecology Hospital from February 2018 to December 2020, recruiting participants in their first trimester of pregnancy. Baseline SII and SIRI values were derived from routine clinical blood results, calculated as follows: SII = neutrophil (Neut) count × platelet (PLT) count/lymphocyte (Lymph) count, SIRI = Neut count × monocyte (Mono) count/Lymph count, with participants being grouped by quartiles of their SII or SIRI values. Participants were followed up for GDM with a 75-g, 2-h oral glucose tolerance test (OGTT) at 24–28 weeks of gestation using the glucose thresholds of the International Association of Diabetes and Pregnancy Study Groups (IADPSG). Logistic regression was used to analyze the odds ratios (ORs) (95% confidence intervals [CIs]) for the the associations between SII, SIRI, and the risk of GDM.
Results:. Among the 28,124 women included in the study, the average age was 31.8 ± 3.8 years, and 15.76% (4432/28,124) developed GDM. Higher SII and SIRI quartiles were correlated with increased GDM rates, with rates ranging from 12.26% (862/7031) in the lowest quartile to 20.10% (1413/7031) in the highest quartile for the SII (Ptrend <0.001) and 11.92–19.31% for the SIRI (Ptrend <0.001). The ORs (95% CIs) of the second, third, and fourth SII quartiles were 1.09 (0.98–1.21), 1.21 (1.09–1.34), and 1.39 (1.26–1.54), respectively. The SIRI findings paralleled the SII outcomes. For the second through fourth quartiles, the ORs (95% CIs) were 1.24 (1.12–1.38), 1.41 (1.27–1.57), and 1.64 (1.48–1.82), respectively. These associations were maintained in subgroup and sensitivity analyses.
Conclusion:. The SII and SIRI are potential independent risk factors contributing to the onset of GDM. |
| format | Article |
| id | doaj-art-ba151dbc30dc43969dd1ebcbc2aee39c |
| institution | Kabale University |
| issn | 0366-6999 2542-5641 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wolters Kluwer |
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| series | Chinese Medical Journal |
| spelling | doaj-art-ba151dbc30dc43969dd1ebcbc2aee39c2025-08-20T03:42:45ZengWolters KluwerChinese Medical Journal0366-69992542-56412025-03-01138672973710.1097/CM9.0000000000003236202503200-00010Associations of systemic immune-inflammation index and systemic inflammation response index with maternal gestational diabetes mellitus: Evidence from a prospective birth cohort studyShuanghua Xie0Enjie Zhang1Shen Gao2Shaofei Su3Jianhui Liu4Yue Zhang5Yingyi Luan6Kaikun Huang7Minhui Hu8Xueran Wang9Hao Xing10Ruixia Liu11Wentao Yue12Chenghong Yin13Jinjiao Li1 Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China1 Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China1 Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China1 Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China1 Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China2 Department of Research Management, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China1 Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China1 Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China1 Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China1 Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China1 Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China1 Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China2 Department of Research Management, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China3 Office of Hospital Administration, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, ChinaAbstract. Background:. The role of inflammation in the development of gestational diabetes mellitus (GDM) has recently become a focus of research. The systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI), novel indices, reflect the body’s chronic immune-inflammatory state. This study aimed to investigate the associations between the SII or SIRI and GDM. Methods:. A prospective birth cohort study was conducted at Beijing Obstetrics and Gynecology Hospital from February 2018 to December 2020, recruiting participants in their first trimester of pregnancy. Baseline SII and SIRI values were derived from routine clinical blood results, calculated as follows: SII = neutrophil (Neut) count × platelet (PLT) count/lymphocyte (Lymph) count, SIRI = Neut count × monocyte (Mono) count/Lymph count, with participants being grouped by quartiles of their SII or SIRI values. Participants were followed up for GDM with a 75-g, 2-h oral glucose tolerance test (OGTT) at 24–28 weeks of gestation using the glucose thresholds of the International Association of Diabetes and Pregnancy Study Groups (IADPSG). Logistic regression was used to analyze the odds ratios (ORs) (95% confidence intervals [CIs]) for the the associations between SII, SIRI, and the risk of GDM. Results:. Among the 28,124 women included in the study, the average age was 31.8 ± 3.8 years, and 15.76% (4432/28,124) developed GDM. Higher SII and SIRI quartiles were correlated with increased GDM rates, with rates ranging from 12.26% (862/7031) in the lowest quartile to 20.10% (1413/7031) in the highest quartile for the SII (Ptrend <0.001) and 11.92–19.31% for the SIRI (Ptrend <0.001). The ORs (95% CIs) of the second, third, and fourth SII quartiles were 1.09 (0.98–1.21), 1.21 (1.09–1.34), and 1.39 (1.26–1.54), respectively. The SIRI findings paralleled the SII outcomes. For the second through fourth quartiles, the ORs (95% CIs) were 1.24 (1.12–1.38), 1.41 (1.27–1.57), and 1.64 (1.48–1.82), respectively. These associations were maintained in subgroup and sensitivity analyses. Conclusion:. The SII and SIRI are potential independent risk factors contributing to the onset of GDM.http://journals.lww.com/10.1097/CM9.0000000000003236 |
| spellingShingle | Shuanghua Xie Enjie Zhang Shen Gao Shaofei Su Jianhui Liu Yue Zhang Yingyi Luan Kaikun Huang Minhui Hu Xueran Wang Hao Xing Ruixia Liu Wentao Yue Chenghong Yin Jinjiao Li Associations of systemic immune-inflammation index and systemic inflammation response index with maternal gestational diabetes mellitus: Evidence from a prospective birth cohort study Chinese Medical Journal |
| title | Associations of systemic immune-inflammation index and systemic inflammation response index with maternal gestational diabetes mellitus: Evidence from a prospective birth cohort study |
| title_full | Associations of systemic immune-inflammation index and systemic inflammation response index with maternal gestational diabetes mellitus: Evidence from a prospective birth cohort study |
| title_fullStr | Associations of systemic immune-inflammation index and systemic inflammation response index with maternal gestational diabetes mellitus: Evidence from a prospective birth cohort study |
| title_full_unstemmed | Associations of systemic immune-inflammation index and systemic inflammation response index with maternal gestational diabetes mellitus: Evidence from a prospective birth cohort study |
| title_short | Associations of systemic immune-inflammation index and systemic inflammation response index with maternal gestational diabetes mellitus: Evidence from a prospective birth cohort study |
| title_sort | associations of systemic immune inflammation index and systemic inflammation response index with maternal gestational diabetes mellitus evidence from a prospective birth cohort study |
| url | http://journals.lww.com/10.1097/CM9.0000000000003236 |
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