Landscape of Histone Posttranslational Modifications in Osteoarthritis
Siyu Zhao, Jia Zheng, Songkai Yue, Xiaoyang Chen, Yonghui Dong Department of Orthopedics, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of ChinaCorrespondence: Yonghui Dong, Department of Orthopedics, Henan Provincial People’s Hosp...
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Dove Medical Press
2025-06-01
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| Series: | Journal of Inflammation Research |
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| Online Access: | https://www.dovepress.com/landscape-of-histone-posttranslational-modifications-in-osteoarthritis-peer-reviewed-fulltext-article-JIR |
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| author | Zhao S Zheng J Yue S Chen X Dong Y |
| author_facet | Zhao S Zheng J Yue S Chen X Dong Y |
| author_sort | Zhao S |
| collection | DOAJ |
| description | Siyu Zhao, Jia Zheng, Songkai Yue, Xiaoyang Chen, Yonghui Dong Department of Orthopedics, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of ChinaCorrespondence: Yonghui Dong, Department of Orthopedics, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Zhengzhou, 450003, People’s Republic of China, Email dongyh@zzu.edu.cnAbstract: Osteoarthritis (OA) is a complex, progressive, and age-associated disease characterized by aberrant epigenetic expression. Epigenetic analysis has helped clarify the role of histone post-translational modifications (PTMs) in OA. PTMs affect histone structure and function and, therefore, regulate the expression of genes implicated in various biological processes. The roles of histone methylation and acetylation in OA progression—including extracellular collagen degradation and matrix destruction—have been thoroughly analyzed. Though several studies have shown that histone PTMs are related to OA, summative investigations in this area are lacking. The present literature review examines the relationships between histone PTMs and OA. It focuses mainly on methylation, acetylation, phosphorylation, lactylation, ubiquitination, and the roles of the histone methyltransferase (HMT)/histone demethylase (HDMT) and histone acetyltransferase (HAT)/histone deacetylase (HDAC) families in OA development. We used epigenetic tools for discovering new OA treatments. This review offers new perspectives for future studies on OA pathogenesis and treatment.Keywords: osteoarthritis, histone modifications, epigenetic, cartilage, drug targets |
| format | Article |
| id | doaj-art-ba1400325c5047a899cb29ee1d0ce3fb |
| institution | Kabale University |
| issn | 1178-7031 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj-art-ba1400325c5047a899cb29ee1d0ce3fb2025-08-20T03:32:36ZengDove Medical PressJournal of Inflammation Research1178-70312025-06-01Volume 18Issue 178937906103950Landscape of Histone Posttranslational Modifications in OsteoarthritisZhao SZheng J0Yue S1Chen X2Dong Y3OrthopedicsOrthopedicsHenan Provincial People's HospitalOrthopedicsSiyu Zhao, Jia Zheng, Songkai Yue, Xiaoyang Chen, Yonghui Dong Department of Orthopedics, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of ChinaCorrespondence: Yonghui Dong, Department of Orthopedics, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Zhengzhou, 450003, People’s Republic of China, Email dongyh@zzu.edu.cnAbstract: Osteoarthritis (OA) is a complex, progressive, and age-associated disease characterized by aberrant epigenetic expression. Epigenetic analysis has helped clarify the role of histone post-translational modifications (PTMs) in OA. PTMs affect histone structure and function and, therefore, regulate the expression of genes implicated in various biological processes. The roles of histone methylation and acetylation in OA progression—including extracellular collagen degradation and matrix destruction—have been thoroughly analyzed. Though several studies have shown that histone PTMs are related to OA, summative investigations in this area are lacking. The present literature review examines the relationships between histone PTMs and OA. It focuses mainly on methylation, acetylation, phosphorylation, lactylation, ubiquitination, and the roles of the histone methyltransferase (HMT)/histone demethylase (HDMT) and histone acetyltransferase (HAT)/histone deacetylase (HDAC) families in OA development. We used epigenetic tools for discovering new OA treatments. This review offers new perspectives for future studies on OA pathogenesis and treatment.Keywords: osteoarthritis, histone modifications, epigenetic, cartilage, drug targetshttps://www.dovepress.com/landscape-of-histone-posttranslational-modifications-in-osteoarthritis-peer-reviewed-fulltext-article-JIRosteoarthritishistone modificationsepigeneticcartilagedrug targets |
| spellingShingle | Zhao S Zheng J Yue S Chen X Dong Y Landscape of Histone Posttranslational Modifications in Osteoarthritis Journal of Inflammation Research osteoarthritis histone modifications epigenetic cartilage drug targets |
| title | Landscape of Histone Posttranslational Modifications in Osteoarthritis |
| title_full | Landscape of Histone Posttranslational Modifications in Osteoarthritis |
| title_fullStr | Landscape of Histone Posttranslational Modifications in Osteoarthritis |
| title_full_unstemmed | Landscape of Histone Posttranslational Modifications in Osteoarthritis |
| title_short | Landscape of Histone Posttranslational Modifications in Osteoarthritis |
| title_sort | landscape of histone posttranslational modifications in osteoarthritis |
| topic | osteoarthritis histone modifications epigenetic cartilage drug targets |
| url | https://www.dovepress.com/landscape-of-histone-posttranslational-modifications-in-osteoarthritis-peer-reviewed-fulltext-article-JIR |
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