Attenuating Mutations in Usutu Virus: Towards Understanding Orthoflavivirus Virulence Determinants and Live Attenuated Vaccine Design

Attenuating Mutations in Usutu Virus: Towards Understanding Orthoflavivirus Virulence Determinants and Live Attenuated Vaccine Design

Background/Objectives: Understanding virulence determinants can inform safer and more efficacious live attenuated vaccine design. However, applying this knowledge across related viruses does not always result in conserved phenotypes from similar mutants. Methods: Using Usutu virus (USUV), an emergin...

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Bibliographic Details
Main Authors: Johanna M. Duyvestyn, Peter J. Bredenbeek, Marie J. Gruters, Ali Tas, Tessa Nelemans, Marjolein Kikkert, Martijn J. van Hemert
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Vaccines
Subjects:
orthoflavivirus
Usutu virus
vaccine
attenuation
animal model
emerging virus
Online Access:https://www.mdpi.com/2076-393X/13/5/495
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