Molecular classification of hormone receptor-positive /HER2-positive breast cancer reveals potential neoadjuvant therapeutic strategies

Molecular classification of hormone receptor-positive /HER2-positive breast cancer reveals potential neoadjuvant therapeutic strategies

Abstract Significant heterogeneity exists in hormone receptor (HR)-positive/HER2-positive (HR+/HER2+) breast cancer, contributing to suboptimal pathological complete response rates with conventional neoadjuvant treatment regimens. Overcoming this challenge requires precise molecular classification,...

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Main Authors: Chao Liu, Lisha Sun, Nan Niu, Pengjie Hou, Guanglei Chen, Hao Wang, Zhan Zhang, Xiaofan Jiang, Qianshi Xu, Yafei Zhao, Yimin Wang, Yuan Shi, Mingxin Liu, Yongliang Yang, Wei Qian, Jiandong Wang, Caigang Liu
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02181-3
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