CACA guidelines for holistic integrative management of central nervous system germ cell tumor
Abstract Central nervous system germ cell tumors (CNS GCTs) are common malignancies of the central nervous system of children and adolescents. The management of CNS GCTs is complex because of varied tumor sites, clinical presentations, treatments and outcomes. Multidisciplinary integrated treatment...
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| Format: | Article |
| Language: | English |
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Springer
2025-06-01
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| Series: | Holistic Integrative Oncology |
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| Online Access: | https://doi.org/10.1007/s44178-025-00168-2 |
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| _version_ | 1849432684192858112 |
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| author | Chao Zhang Xiang Huang Yijin Gao Yang Wang Hongying Ye Hong Chen Junping Zhang Linbo Cai Chunde Li Yuqi Zhang Jingsheng Wang Songtao Qi Shuguang Chu Yuanyuan Huang Bei Zhang Zhongping Chen Rong Zhang |
| author_facet | Chao Zhang Xiang Huang Yijin Gao Yang Wang Hongying Ye Hong Chen Junping Zhang Linbo Cai Chunde Li Yuqi Zhang Jingsheng Wang Songtao Qi Shuguang Chu Yuanyuan Huang Bei Zhang Zhongping Chen Rong Zhang |
| author_sort | Chao Zhang |
| collection | DOAJ |
| description | Abstract Central nervous system germ cell tumors (CNS GCTs) are common malignancies of the central nervous system of children and adolescents. The management of CNS GCTs is complex because of varied tumor sites, clinical presentations, treatments and outcomes. Multidisciplinary integrated treatment involving radiotherapy, chemotherapy and surgery is the most commonly used approach for CNS GCTs worldwide and is essential for achieving favorable clinical outcomes. The Pediatric Oncology Committee of the Chinese Anti-Cancer Association (CACA) has formulated the guidelines for the management of CNS GCTs based on domestic and foreign clinical studies and experiences. The guidelines cover the diagnosis and treatment of primary CNS GCT in the pineal region, the sellar region, and the thalamus and basal ganglia region, recurrent, disseminated, and bifocal/multifocal CNS GCT, as well as traditional Chinese medicine. In these guidelines, different treatment regimens are proposed for secretory or non-secretory GCTs. The therapeutic concepts of primary treatment and second-look surgery are also introduced. The hope is to help standardize the diagnosis and treatment, and further improve the outcomes of CNS GCTs patients. |
| format | Article |
| id | doaj-art-b9fd379703f24b7eab88cb36e7f71d7e |
| institution | Kabale University |
| issn | 2731-4529 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Springer |
| record_format | Article |
| series | Holistic Integrative Oncology |
| spelling | doaj-art-b9fd379703f24b7eab88cb36e7f71d7e2025-08-20T03:27:18ZengSpringerHolistic Integrative Oncology2731-45292025-06-014112110.1007/s44178-025-00168-2CACA guidelines for holistic integrative management of central nervous system germ cell tumorChao Zhang0Xiang Huang1Yijin Gao2Yang Wang3Hongying Ye4Hong Chen5Junping Zhang6Linbo Cai7Chunde Li8Yuqi Zhang9Jingsheng Wang10Songtao Qi11Shuguang Chu12Yuanyuan Huang13Bei Zhang14Zhongping Chen15Rong Zhang16Department of Neurosurgery, Huashan Hospital, Fudan UniversityDepartment of Neurosurgery, Huashan Hospital, Fudan UniversityDepartment of Hematology & Oncology, Shanghai Children’s Medical Center, Shanghai Jiao Tong UniversityDepartment of Radiotherapy, Huashan Hospital, Fudan UniversityDepartment of Endocrinology, Huashan Hospital, Fudan UniversityDepartment of Pathology, Huashan Hospital, Fudan UniversityNeuro-Oncology Chemotherapy Center, Sanbo Brain Hospital, Capital Medical UniversityDepartment of Oncology, Guangdong Sanjiu Brain HospitalDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Tsinghua University Yuquan HospitalDepartment of Neurosurgery, Shenzhen Children’s HospitalDepartment of Neurosurgery, Nanfang Hospital, Southern Medical UniverstiyDepartment of Radiology, Shanghai East Hospital, Tongji UniversityDepartment of Traditional Chinese Medicine, Sun Yat-Sen University Cancer CenterDepartment of Traditional Chinese Medicine, Sun Yat-Sen University Cancer CenterDepartment of Neurosurgery, Sun Yat-Sen University Cancer CenterDepartment of Neurosurgery, Huashan Hospital, Fudan UniversityAbstract Central nervous system germ cell tumors (CNS GCTs) are common malignancies of the central nervous system of children and adolescents. The management of CNS GCTs is complex because of varied tumor sites, clinical presentations, treatments and outcomes. Multidisciplinary integrated treatment involving radiotherapy, chemotherapy and surgery is the most commonly used approach for CNS GCTs worldwide and is essential for achieving favorable clinical outcomes. The Pediatric Oncology Committee of the Chinese Anti-Cancer Association (CACA) has formulated the guidelines for the management of CNS GCTs based on domestic and foreign clinical studies and experiences. The guidelines cover the diagnosis and treatment of primary CNS GCT in the pineal region, the sellar region, and the thalamus and basal ganglia region, recurrent, disseminated, and bifocal/multifocal CNS GCT, as well as traditional Chinese medicine. In these guidelines, different treatment regimens are proposed for secretory or non-secretory GCTs. The therapeutic concepts of primary treatment and second-look surgery are also introduced. The hope is to help standardize the diagnosis and treatment, and further improve the outcomes of CNS GCTs patients.https://doi.org/10.1007/s44178-025-00168-2GuidelineGerm cell tumorCentral nervous systemIntegrative managementPediatricGerminoma |
| spellingShingle | Chao Zhang Xiang Huang Yijin Gao Yang Wang Hongying Ye Hong Chen Junping Zhang Linbo Cai Chunde Li Yuqi Zhang Jingsheng Wang Songtao Qi Shuguang Chu Yuanyuan Huang Bei Zhang Zhongping Chen Rong Zhang CACA guidelines for holistic integrative management of central nervous system germ cell tumor Holistic Integrative Oncology Guideline Germ cell tumor Central nervous system Integrative management Pediatric Germinoma |
| title | CACA guidelines for holistic integrative management of central nervous system germ cell tumor |
| title_full | CACA guidelines for holistic integrative management of central nervous system germ cell tumor |
| title_fullStr | CACA guidelines for holistic integrative management of central nervous system germ cell tumor |
| title_full_unstemmed | CACA guidelines for holistic integrative management of central nervous system germ cell tumor |
| title_short | CACA guidelines for holistic integrative management of central nervous system germ cell tumor |
| title_sort | caca guidelines for holistic integrative management of central nervous system germ cell tumor |
| topic | Guideline Germ cell tumor Central nervous system Integrative management Pediatric Germinoma |
| url | https://doi.org/10.1007/s44178-025-00168-2 |
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