Evaluation of tumor infiltrating lymphocytes in breast carcinomas
Background: Among the parameters that have a prognostic and/or predictive significance to therapeutic response, in the case of breast carcinoma, the study of tumor-infiltrating lymphocytes in breast carcinomas is emerging. The present study aimed to access the clinicopathological profiles of tumor-i...
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| Format: | Article |
| Language: | English |
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Association of Clinical Pathologists of Nepal
2022-09-01
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| Series: | Journal of Pathology of Nepal |
| Online Access: | https://www.nepjol.info/index.php/JPN/article/view/47200 |
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| author | Shovana Karki Sansar Babu Tiwari Alina Basnet |
| author_facet | Shovana Karki Sansar Babu Tiwari Alina Basnet |
| author_sort | Shovana Karki |
| collection | DOAJ |
| description | Background: Among the parameters that have a prognostic and/or predictive significance to therapeutic response, in the case of breast carcinoma, the study of tumor-infiltrating lymphocytes in breast carcinomas is emerging. The present study aimed to access the clinicopathological profiles of tumor-infiltrating lymphocytes in patients with primary breast carcinoma.
Materials and Methods: Information was collected from the archive of the Department of Pathology, about invasive breast cancers diagnosed between April 2019 –March 2020. Hormone receptor status and Ki-67 index were assessed. For tumor-infiltrating lymphocytes, hematoxylin and eosin sections were evaluated following the guidelines of the “International Working Group for tumor-infiltrating lymphocytes in Breast Cancer—2014”.
Results: High tumor-infiltrating lymphocytes were seen in 64.2% and 43.8% in ages < 50 and > 50 respectively. All cases of invasive lobular carcinoma had low tumor-infiltrating lymphocytes. 62.5% of T1 tumors were associated with low TILs whereas 80% of low tumor-infiltrating lymphocytes were T3. 71.4% of lymph node-positive tumors had low tumor-infiltrating lymphocytes. All breast cancers showed lymphocytic infiltrate. 40% of the tumors showed intermediate to high tumor-infiltrating lymphocytes. Lymphocyte-predominant breast cancers were 30%. Among the LPBC, 55.5% were triple-negative breast cancers, 33.3% were HR+, and 11.2% were HER2 positive.
Conclusions: Low tumor-infiltrating lymphocytes presented at an advanced stage of the disease at the time of diagnosis. tumor-infiltrating lymphocytes in breasts decreased with increasing age. LPBCs were predominantly TNBCs. All breast cancers were immunogenic, stating the necessity to report tumor-infiltrating lymphocytes in all breast carcinomas. |
| format | Article |
| id | doaj-art-b9f2c2b7d915401bbe151066f06508be |
| institution | Kabale University |
| issn | 2091-0797 2091-0908 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Association of Clinical Pathologists of Nepal |
| record_format | Article |
| series | Journal of Pathology of Nepal |
| spelling | doaj-art-b9f2c2b7d915401bbe151066f06508be2025-08-21T07:03:01ZengAssociation of Clinical Pathologists of NepalJournal of Pathology of Nepal2091-07972091-09082022-09-011221909191210.3126/jpn.v12i2.4720074267Evaluation of tumor infiltrating lymphocytes in breast carcinomasShovana Karki0https://orcid.org/0000-0001-5429-2422Sansar Babu Tiwari1https://orcid.org/0000-0001-5429-2422Alina Basnet2https://orcid.org/0000-0001-5429-2422Institute of Medicine, Tribhuvan University Teaching HospitalInstitute of Medicine, Tribhuvan University Teaching HospitalInstitute of Medicine, Tribhuvan University Teaching HospitalBackground: Among the parameters that have a prognostic and/or predictive significance to therapeutic response, in the case of breast carcinoma, the study of tumor-infiltrating lymphocytes in breast carcinomas is emerging. The present study aimed to access the clinicopathological profiles of tumor-infiltrating lymphocytes in patients with primary breast carcinoma. Materials and Methods: Information was collected from the archive of the Department of Pathology, about invasive breast cancers diagnosed between April 2019 –March 2020. Hormone receptor status and Ki-67 index were assessed. For tumor-infiltrating lymphocytes, hematoxylin and eosin sections were evaluated following the guidelines of the “International Working Group for tumor-infiltrating lymphocytes in Breast Cancer—2014”. Results: High tumor-infiltrating lymphocytes were seen in 64.2% and 43.8% in ages < 50 and > 50 respectively. All cases of invasive lobular carcinoma had low tumor-infiltrating lymphocytes. 62.5% of T1 tumors were associated with low TILs whereas 80% of low tumor-infiltrating lymphocytes were T3. 71.4% of lymph node-positive tumors had low tumor-infiltrating lymphocytes. All breast cancers showed lymphocytic infiltrate. 40% of the tumors showed intermediate to high tumor-infiltrating lymphocytes. Lymphocyte-predominant breast cancers were 30%. Among the LPBC, 55.5% were triple-negative breast cancers, 33.3% were HR+, and 11.2% were HER2 positive. Conclusions: Low tumor-infiltrating lymphocytes presented at an advanced stage of the disease at the time of diagnosis. tumor-infiltrating lymphocytes in breasts decreased with increasing age. LPBCs were predominantly TNBCs. All breast cancers were immunogenic, stating the necessity to report tumor-infiltrating lymphocytes in all breast carcinomas.https://www.nepjol.info/index.php/JPN/article/view/47200 |
| spellingShingle | Shovana Karki Sansar Babu Tiwari Alina Basnet Evaluation of tumor infiltrating lymphocytes in breast carcinomas Journal of Pathology of Nepal |
| title | Evaluation of tumor infiltrating lymphocytes in breast carcinomas |
| title_full | Evaluation of tumor infiltrating lymphocytes in breast carcinomas |
| title_fullStr | Evaluation of tumor infiltrating lymphocytes in breast carcinomas |
| title_full_unstemmed | Evaluation of tumor infiltrating lymphocytes in breast carcinomas |
| title_short | Evaluation of tumor infiltrating lymphocytes in breast carcinomas |
| title_sort | evaluation of tumor infiltrating lymphocytes in breast carcinomas |
| url | https://www.nepjol.info/index.php/JPN/article/view/47200 |
| work_keys_str_mv | AT shovanakarki evaluationoftumorinfiltratinglymphocytesinbreastcarcinomas AT sansarbabutiwari evaluationoftumorinfiltratinglymphocytesinbreastcarcinomas AT alinabasnet evaluationoftumorinfiltratinglymphocytesinbreastcarcinomas |