Frequency-Specific Changes of Amplitude of Low-Frequency Fluctuations in Patients with Acute Basal Ganglia Ischemic Stroke
Objective. The purpose of this study was to investigate the characteristics of different frequency bands in the spontaneous brain activity among patients with acute basal ganglia ischemic stroke (BGIS). Methods. In the present study, thirty-four patients with acute BGIS and forty-four healthy contro...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2022/4106131 |
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| author | Xuemei Quan Su Hu Chaoguo Meng Lulu Cheng Yujie Lu Yumei Xia Wenmei Li Huo Liang Mengting Li Zhijian Liang |
| author_facet | Xuemei Quan Su Hu Chaoguo Meng Lulu Cheng Yujie Lu Yumei Xia Wenmei Li Huo Liang Mengting Li Zhijian Liang |
| author_sort | Xuemei Quan |
| collection | DOAJ |
| description | Objective. The purpose of this study was to investigate the characteristics of different frequency bands in the spontaneous brain activity among patients with acute basal ganglia ischemic stroke (BGIS). Methods. In the present study, thirty-four patients with acute BGIS and forty-four healthy controls were examined by resting-state functional magnetic resonance imaging (rs-fMRI) from May 2019 to December 2020. Two amplitude methods including amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF) calculated in three frequency bands (conventional frequency band: 0.01-0.08 Hz; slow-5 frequency band: 0.01-0.027 Hz; and slow-4 frequency band: 0.027-0.073 Hz) were conducted to evaluate the spontaneous brain activity in patients with acute BGIS and healthy controls (HCs). Gaussian Random Field Theory (GRF, voxel p<0.01 and cluster p<0.05) correction was applied. The correlation analyses were performed between clinical scores and altered metrics values. Results. Compared to HCs, patients with acute BGIS showed decreased ALFF in the right supramarginal gyrus (SMG) in the conventional and slow-4 bands, increased fALFF in the right middle frontal gyrus (MFG) in the conventional and slow-4 bands, and increased fALFF in the bilateral caudate in the slow-5 frequency band. The fALFF value of the right caudate in the slow-5 frequency band was negatively correlated with the clinical scores. Conclusion. In conclusion, this study showed the alterations in ALFF and fALFF in three frequency bands between patients with acute BGIS and HCs. The results reflected that the abnormal LFO amplitude might be related with different frequency bands and promoted our understanding of pathophysiological mechanism in acute BGIS. |
| format | Article |
| id | doaj-art-b9ef5cbc4b764bf1b02c16876068839b |
| institution | OA Journals |
| issn | 1687-5443 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-b9ef5cbc4b764bf1b02c16876068839b2025-08-20T02:18:57ZengWileyNeural Plasticity1687-54432022-01-01202210.1155/2022/4106131Frequency-Specific Changes of Amplitude of Low-Frequency Fluctuations in Patients with Acute Basal Ganglia Ischemic StrokeXuemei Quan0Su Hu1Chaoguo Meng2Lulu Cheng3Yujie Lu4Yumei Xia5Wenmei Li6Huo Liang7Mengting Li8Zhijian Liang9Department of NeurologySchool of Teacher EducationDepartment of NeurologySchool of Foreign StudiesDepartment of RadiologyDepartment of NeurologySchool of Foreign StudiesDepartment of RehabilitationSchool of Teacher EducationDepartment of NeurologyObjective. The purpose of this study was to investigate the characteristics of different frequency bands in the spontaneous brain activity among patients with acute basal ganglia ischemic stroke (BGIS). Methods. In the present study, thirty-four patients with acute BGIS and forty-four healthy controls were examined by resting-state functional magnetic resonance imaging (rs-fMRI) from May 2019 to December 2020. Two amplitude methods including amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF) calculated in three frequency bands (conventional frequency band: 0.01-0.08 Hz; slow-5 frequency band: 0.01-0.027 Hz; and slow-4 frequency band: 0.027-0.073 Hz) were conducted to evaluate the spontaneous brain activity in patients with acute BGIS and healthy controls (HCs). Gaussian Random Field Theory (GRF, voxel p<0.01 and cluster p<0.05) correction was applied. The correlation analyses were performed between clinical scores and altered metrics values. Results. Compared to HCs, patients with acute BGIS showed decreased ALFF in the right supramarginal gyrus (SMG) in the conventional and slow-4 bands, increased fALFF in the right middle frontal gyrus (MFG) in the conventional and slow-4 bands, and increased fALFF in the bilateral caudate in the slow-5 frequency band. The fALFF value of the right caudate in the slow-5 frequency band was negatively correlated with the clinical scores. Conclusion. In conclusion, this study showed the alterations in ALFF and fALFF in three frequency bands between patients with acute BGIS and HCs. The results reflected that the abnormal LFO amplitude might be related with different frequency bands and promoted our understanding of pathophysiological mechanism in acute BGIS.http://dx.doi.org/10.1155/2022/4106131 |
| spellingShingle | Xuemei Quan Su Hu Chaoguo Meng Lulu Cheng Yujie Lu Yumei Xia Wenmei Li Huo Liang Mengting Li Zhijian Liang Frequency-Specific Changes of Amplitude of Low-Frequency Fluctuations in Patients with Acute Basal Ganglia Ischemic Stroke Neural Plasticity |
| title | Frequency-Specific Changes of Amplitude of Low-Frequency Fluctuations in Patients with Acute Basal Ganglia Ischemic Stroke |
| title_full | Frequency-Specific Changes of Amplitude of Low-Frequency Fluctuations in Patients with Acute Basal Ganglia Ischemic Stroke |
| title_fullStr | Frequency-Specific Changes of Amplitude of Low-Frequency Fluctuations in Patients with Acute Basal Ganglia Ischemic Stroke |
| title_full_unstemmed | Frequency-Specific Changes of Amplitude of Low-Frequency Fluctuations in Patients with Acute Basal Ganglia Ischemic Stroke |
| title_short | Frequency-Specific Changes of Amplitude of Low-Frequency Fluctuations in Patients with Acute Basal Ganglia Ischemic Stroke |
| title_sort | frequency specific changes of amplitude of low frequency fluctuations in patients with acute basal ganglia ischemic stroke |
| url | http://dx.doi.org/10.1155/2022/4106131 |
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