Allergic Rhinitis in Rats Is Associated with an Inflammatory Response of the Hippocampus
Allergic rhinitis (AR) is a major concern in personal and public health, which negatively affects emotions and behavior, leading to cognitive deficits, memory decline, poor school performance, anxiety, and depression. Several cellular and molecular mediators are released in the inflammatory process...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2018/8750464 |
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| _version_ | 1849685755354415104 |
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| author | Shasha Yang Jing Wu Qinxiu Zhang Xinrong Li Daien Liu Bin Zeng Zhiqing Liu Haoran Kang Zhendong Zhong |
| author_facet | Shasha Yang Jing Wu Qinxiu Zhang Xinrong Li Daien Liu Bin Zeng Zhiqing Liu Haoran Kang Zhendong Zhong |
| author_sort | Shasha Yang |
| collection | DOAJ |
| description | Allergic rhinitis (AR) is a major concern in personal and public health, which negatively affects emotions and behavior, leading to cognitive deficits, memory decline, poor school performance, anxiety, and depression. Several cellular and molecular mediators are released in the inflammatory process of AR and activate common neuroimmune mechanisms, involving emotionally relevant circuits and the induction of anxiety. Responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis to allergic processes have been reported, which may also include responsiveness of the hippocampus, cortex, and other brain regions. Here, we have used an optimized rat model of AR to explore whether the disease has a relationship with inflammatory responses in the hippocampus. AR was established in adult rats by ovalbumin sensitization, and the expression of various inflammatory substances in the hippocampus was measured by specific assays. Comparison between experimental and various control groups of animals revealed an association of AR with significant upregulation of substance P, microglia surface antigen (CD11b), glial fibrillary acid protein (GFAP), tumor necrosis factor-α (TNF-α), and interleukin 6 (IL-6) in the hippocampus. Thus, we hypothesize that the AR challenge may activate these inflammatory mediators in the hippocampus, which in turn contribute to the abnormal behavior and neurological deficits associated with AR. |
| format | Article |
| id | doaj-art-b9ef5aee76e9425bb21df64bd65e72e5 |
| institution | DOAJ |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-b9ef5aee76e9425bb21df64bd65e72e52025-08-20T03:22:58ZengWileyBehavioural Neurology0953-41801875-85842018-01-01201810.1155/2018/87504648750464Allergic Rhinitis in Rats Is Associated with an Inflammatory Response of the HippocampusShasha Yang0Jing Wu1Qinxiu Zhang2Xinrong Li3Daien Liu4Bin Zeng5Zhiqing Liu6Haoran Kang7Zhendong Zhong8Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan province, ChinaGuiyang College of Traditional Chinese Medicine, Guiyang, Guizhou province, ChinaDepartment of Otorhinolaryngology, Head and Neck Surgery, Teaching Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan province, ChinaDepartment of Otorhinolaryngology, Head and Neck Surgery, Teaching Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan province, ChinaChengdu University of Traditional Chinese Medicine, Chengdu, Sichuan province, ChinaChengdu University of Traditional Chinese Medicine, Chengdu, Sichuan province, ChinaChengdu University of Traditional Chinese Medicine, Chengdu, Sichuan province, ChinaChengdu University of Traditional Chinese Medicine, Chengdu, Sichuan province, ChinaSichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, ChinaAllergic rhinitis (AR) is a major concern in personal and public health, which negatively affects emotions and behavior, leading to cognitive deficits, memory decline, poor school performance, anxiety, and depression. Several cellular and molecular mediators are released in the inflammatory process of AR and activate common neuroimmune mechanisms, involving emotionally relevant circuits and the induction of anxiety. Responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis to allergic processes have been reported, which may also include responsiveness of the hippocampus, cortex, and other brain regions. Here, we have used an optimized rat model of AR to explore whether the disease has a relationship with inflammatory responses in the hippocampus. AR was established in adult rats by ovalbumin sensitization, and the expression of various inflammatory substances in the hippocampus was measured by specific assays. Comparison between experimental and various control groups of animals revealed an association of AR with significant upregulation of substance P, microglia surface antigen (CD11b), glial fibrillary acid protein (GFAP), tumor necrosis factor-α (TNF-α), and interleukin 6 (IL-6) in the hippocampus. Thus, we hypothesize that the AR challenge may activate these inflammatory mediators in the hippocampus, which in turn contribute to the abnormal behavior and neurological deficits associated with AR.http://dx.doi.org/10.1155/2018/8750464 |
| spellingShingle | Shasha Yang Jing Wu Qinxiu Zhang Xinrong Li Daien Liu Bin Zeng Zhiqing Liu Haoran Kang Zhendong Zhong Allergic Rhinitis in Rats Is Associated with an Inflammatory Response of the Hippocampus Behavioural Neurology |
| title | Allergic Rhinitis in Rats Is Associated with an Inflammatory Response of the Hippocampus |
| title_full | Allergic Rhinitis in Rats Is Associated with an Inflammatory Response of the Hippocampus |
| title_fullStr | Allergic Rhinitis in Rats Is Associated with an Inflammatory Response of the Hippocampus |
| title_full_unstemmed | Allergic Rhinitis in Rats Is Associated with an Inflammatory Response of the Hippocampus |
| title_short | Allergic Rhinitis in Rats Is Associated with an Inflammatory Response of the Hippocampus |
| title_sort | allergic rhinitis in rats is associated with an inflammatory response of the hippocampus |
| url | http://dx.doi.org/10.1155/2018/8750464 |
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