Alteration of 11β-Hydroxysteroid Dehydrogenase Type 1 and Glucocorticoid Receptor by Ethanol in Rat Liver and Mouse Hepatoma Cells

Alcohol is a potential risk factor of type 2 diabetes, but its underlying mechanism is unclear. To explore this issue, Wistar rats and mouse hepatoma cells (Hepa 1–6) were exposed to ethanol, 8 g·kg−1·d−1 for 3 months and 100 mM for 48 h, respectively. Glucose and insulin tolerance tests in vivo wer...

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Bibliographic Details
Main Authors: Zhaojie Meng, Xueying Bao, Ming Zhang, Shengnan Wei, Wenguang Chang, Jing Li, Li Chen, B. L. Grégoire Nyomba
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Journal of Diabetes Research
Online Access:http://dx.doi.org/10.1155/2013/218102
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