Variations in neuronal cytoskeletal integrity affect directed communication in distributed networks during inhibitory control
Abstract To ensure goal-directed behavior in daily life, the use of inhibitory control is of great importance. The aim of this study is to shed light on the underlying neuronal mechanisms of inhibitory control and the relevance of cytoarchitectonic integrity in it. We combine sophisticated EEG analy...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-03-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-07974-4 |
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| _version_ | 1849392122257473536 |
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| author | Julia Elmers Moritz Mückschel Katja Akgün Tjalf Ziemssen Christian Beste |
| author_facet | Julia Elmers Moritz Mückschel Katja Akgün Tjalf Ziemssen Christian Beste |
| author_sort | Julia Elmers |
| collection | DOAJ |
| description | Abstract To ensure goal-directed behavior in daily life, the use of inhibitory control is of great importance. The aim of this study is to shed light on the underlying neuronal mechanisms of inhibitory control and the relevance of cytoarchitectonic integrity in it. We combine sophisticated EEG analysis techniques assessing directed communication between brain structures with measurements of neurofilaments as an index of cytoarchitectonic integrity. We show that an extensive theta band activity related neural network with fronto-temporal, parietal, and occipital brain regions is active during response inhibition. Importantly, cytoarchitectonic integrity as measured using neurofilaments modulates nonlinear directional connectivity, particularly when complex reconfiguration of perceptual and action mapping is required. The study thus shows an inter-relation between different levels of biological functioning—the level of cytoarchitectonic integrity and neurophysiological directed communication—for inhibitory control and emphasizes the role of nonlinear brain connectivity in cognitive control. |
| format | Article |
| id | doaj-art-b9edd3a8bef54bc1b462133703d70cc4 |
| institution | Kabale University |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-b9edd3a8bef54bc1b462133703d70cc42025-08-20T03:40:50ZengNature PortfolioCommunications Biology2399-36422025-03-018111210.1038/s42003-025-07974-4Variations in neuronal cytoskeletal integrity affect directed communication in distributed networks during inhibitory controlJulia Elmers0Moritz Mückschel1Katja Akgün2Tjalf Ziemssen3Christian Beste4Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of MedicineCognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of MedicineCenter of Clinical Neuroscience, Department of Neurology, University Hospital Carl Gustav CarusCenter of Clinical Neuroscience, Department of Neurology, University Hospital Carl Gustav CarusCognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of MedicineAbstract To ensure goal-directed behavior in daily life, the use of inhibitory control is of great importance. The aim of this study is to shed light on the underlying neuronal mechanisms of inhibitory control and the relevance of cytoarchitectonic integrity in it. We combine sophisticated EEG analysis techniques assessing directed communication between brain structures with measurements of neurofilaments as an index of cytoarchitectonic integrity. We show that an extensive theta band activity related neural network with fronto-temporal, parietal, and occipital brain regions is active during response inhibition. Importantly, cytoarchitectonic integrity as measured using neurofilaments modulates nonlinear directional connectivity, particularly when complex reconfiguration of perceptual and action mapping is required. The study thus shows an inter-relation between different levels of biological functioning—the level of cytoarchitectonic integrity and neurophysiological directed communication—for inhibitory control and emphasizes the role of nonlinear brain connectivity in cognitive control.https://doi.org/10.1038/s42003-025-07974-4 |
| spellingShingle | Julia Elmers Moritz Mückschel Katja Akgün Tjalf Ziemssen Christian Beste Variations in neuronal cytoskeletal integrity affect directed communication in distributed networks during inhibitory control Communications Biology |
| title | Variations in neuronal cytoskeletal integrity affect directed communication in distributed networks during inhibitory control |
| title_full | Variations in neuronal cytoskeletal integrity affect directed communication in distributed networks during inhibitory control |
| title_fullStr | Variations in neuronal cytoskeletal integrity affect directed communication in distributed networks during inhibitory control |
| title_full_unstemmed | Variations in neuronal cytoskeletal integrity affect directed communication in distributed networks during inhibitory control |
| title_short | Variations in neuronal cytoskeletal integrity affect directed communication in distributed networks during inhibitory control |
| title_sort | variations in neuronal cytoskeletal integrity affect directed communication in distributed networks during inhibitory control |
| url | https://doi.org/10.1038/s42003-025-07974-4 |
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