Myocardial Recovery in Cardiogenic Shock
The overarching goal of cardiogenic shock (CS) therapy is ensuring long-term survival. In recent years, increasing emphasis has been placed on analyzing mechanisms to improve outcomes in CS. This includes averting in-hospital mortality, modifying the disease process by promoting heart recovery while...
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| Format: | Article |
| Language: | English |
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Houston Methodist DeBakey Heart & Vascular Center
2024-08-01
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| Series: | Methodist DeBakey Cardiovascular Journal |
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| Online Access: | https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1383 |
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| author | Kevin John Adnan Khalif Masaki Tsukashita Manreet K. Kanwar |
| author_facet | Kevin John Adnan Khalif Masaki Tsukashita Manreet K. Kanwar |
| author_sort | Kevin John |
| collection | DOAJ |
| description | The overarching goal of cardiogenic shock (CS) therapy is ensuring long-term survival. In recent years, increasing emphasis has been placed on analyzing mechanisms to improve outcomes in CS. This includes averting in-hospital mortality, modifying the disease process by promoting heart recovery while avoiding multiorgan failure, and circumventing complications related to both CS and treatment strategies deployed to treat CS. Heart replacement therapies represent a viable strategy for long-term survival but are restricted to a small, select percentage of patients. In this review we focus on pathophysiology of the shock state, with an emphasis on addressing reversible etiologies contributing to the decompensated state, optimizing physiological factors for recovery, and identifying therapeutic targets to promote recovery. We also review the known predictors of myocardial recovery, regardless of the etiology of CS. Lastly, we highlight the current gaps in knowledge in this field and support additional high-quality studies focusing on myocardial recovery in CS. |
| format | Article |
| id | doaj-art-b9e8d34cffec49a9b98d4937f7e501a4 |
| institution | OA Journals |
| issn | 1947-6108 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Houston Methodist DeBakey Heart & Vascular Center |
| record_format | Article |
| series | Methodist DeBakey Cardiovascular Journal |
| spelling | doaj-art-b9e8d34cffec49a9b98d4937f7e501a42025-08-20T02:33:23ZengHouston Methodist DeBakey Heart & Vascular CenterMethodist DeBakey Cardiovascular Journal1947-61082024-08-01204647510.14797/mdcvj.13831361Myocardial Recovery in Cardiogenic ShockKevin John0https://orcid.org/0000-0003-3382-0294Adnan Khalif1https://orcid.org/0000-0002-8235-4253Masaki Tsukashita2https://orcid.org/0000-0001-9387-4759Manreet K. Kanwar3https://orcid.org/0000-0002-7280-5268Tufts Medical Center, Boston, MassachusettsCardiovascular Institute at Allegheny Health Network, Pittsburgh, PennsylvaniaCardiovascular Institute at Allegheny Health Network, Pittsburgh, PennsylvaniaCardiovascular Institute at Allegheny Health Network, Pittsburgh, PennsylvaniaThe overarching goal of cardiogenic shock (CS) therapy is ensuring long-term survival. In recent years, increasing emphasis has been placed on analyzing mechanisms to improve outcomes in CS. This includes averting in-hospital mortality, modifying the disease process by promoting heart recovery while avoiding multiorgan failure, and circumventing complications related to both CS and treatment strategies deployed to treat CS. Heart replacement therapies represent a viable strategy for long-term survival but are restricted to a small, select percentage of patients. In this review we focus on pathophysiology of the shock state, with an emphasis on addressing reversible etiologies contributing to the decompensated state, optimizing physiological factors for recovery, and identifying therapeutic targets to promote recovery. We also review the known predictors of myocardial recovery, regardless of the etiology of CS. Lastly, we highlight the current gaps in knowledge in this field and support additional high-quality studies focusing on myocardial recovery in CS.https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1383cardiogenic shockmyocardial recoverymechanical circulatory supportguideline-directed medical therapy |
| spellingShingle | Kevin John Adnan Khalif Masaki Tsukashita Manreet K. Kanwar Myocardial Recovery in Cardiogenic Shock Methodist DeBakey Cardiovascular Journal cardiogenic shock myocardial recovery mechanical circulatory support guideline-directed medical therapy |
| title | Myocardial Recovery in Cardiogenic Shock |
| title_full | Myocardial Recovery in Cardiogenic Shock |
| title_fullStr | Myocardial Recovery in Cardiogenic Shock |
| title_full_unstemmed | Myocardial Recovery in Cardiogenic Shock |
| title_short | Myocardial Recovery in Cardiogenic Shock |
| title_sort | myocardial recovery in cardiogenic shock |
| topic | cardiogenic shock myocardial recovery mechanical circulatory support guideline-directed medical therapy |
| url | https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1383 |
| work_keys_str_mv | AT kevinjohn myocardialrecoveryincardiogenicshock AT adnankhalif myocardialrecoveryincardiogenicshock AT masakitsukashita myocardialrecoveryincardiogenicshock AT manreetkkanwar myocardialrecoveryincardiogenicshock |