Can the Response to Eradication Therapy in Helicobacter pylori Infection be Predicted?
The failure to eradicate Helicobacter pylori infection with antibiotic therapy has become a major clinical problem, not entirely accounted for by either poor compliance or antibiotic resistance. Recognition that failed eradication is one outcome of the host-parasite relationship focuses attention on...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2003-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2003/585862 |
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| _version_ | 1850176051221626880 |
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| author | Robert Clancy Thomas Borody Zhigang Ren Gerald Pang |
| author_facet | Robert Clancy Thomas Borody Zhigang Ren Gerald Pang |
| author_sort | Robert Clancy |
| collection | DOAJ |
| description | The failure to eradicate Helicobacter pylori infection with antibiotic
therapy has become a major clinical problem, not entirely accounted
for by either poor compliance or antibiotic resistance. Recognition
that failed eradication is one outcome of the host-parasite relationship
focuses attention on impaired host protection as a determinant
of nonresponse to antibiotics. A secreted interleukin (IL)-4 whole
blood assay was developed to determine whether persistent infection
was contributed to by impaired cytokine responses. The blood assay
was shown to correlate well with mucosal organ cultures.
Significantly lower levels of IL-4 were detected in the whole blood
assays in 11 subjects with failed eradication compared with subjects
with successful eradication (P<0.05). This latter group underwent a
Th1 to Th0 ‘switch’, which appears to be important to successful
eradication. Detection of subjects at risk for failing to eradicate infection
with standard combination therapy, by virtue of low secreted
IL-4 in whole blood cultures, may have clinical value. |
| format | Article |
| id | doaj-art-b9e2f526193d401ab398dc20c6dff8c5 |
| institution | OA Journals |
| issn | 0835-7900 |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-b9e2f526193d401ab398dc20c6dff8c52025-08-20T02:19:19ZengWileyCanadian Journal of Gastroenterology0835-79002003-01-0117Suppl B58B61B10.1155/2003/585862Can the Response to Eradication Therapy in Helicobacter pylori Infection be Predicted?Robert Clancy0Thomas Borody1Zhigang Ren2Gerald Pang3Discipline of Immunology and Microbiology, University of Newcastle, Newcastle, AustraliaThe Centre for Digestive Disease, Five Dock, New South Wales, AustraliaVasse Research Institute, Newcastle, AustraliaDiscipline of Immunology and Microbiology, University of Newcastle, Newcastle, AustraliaThe failure to eradicate Helicobacter pylori infection with antibiotic therapy has become a major clinical problem, not entirely accounted for by either poor compliance or antibiotic resistance. Recognition that failed eradication is one outcome of the host-parasite relationship focuses attention on impaired host protection as a determinant of nonresponse to antibiotics. A secreted interleukin (IL)-4 whole blood assay was developed to determine whether persistent infection was contributed to by impaired cytokine responses. The blood assay was shown to correlate well with mucosal organ cultures. Significantly lower levels of IL-4 were detected in the whole blood assays in 11 subjects with failed eradication compared with subjects with successful eradication (P<0.05). This latter group underwent a Th1 to Th0 ‘switch’, which appears to be important to successful eradication. Detection of subjects at risk for failing to eradicate infection with standard combination therapy, by virtue of low secreted IL-4 in whole blood cultures, may have clinical value.http://dx.doi.org/10.1155/2003/585862 |
| spellingShingle | Robert Clancy Thomas Borody Zhigang Ren Gerald Pang Can the Response to Eradication Therapy in Helicobacter pylori Infection be Predicted? Canadian Journal of Gastroenterology |
| title | Can the Response to Eradication Therapy in Helicobacter pylori Infection be Predicted? |
| title_full | Can the Response to Eradication Therapy in Helicobacter pylori Infection be Predicted? |
| title_fullStr | Can the Response to Eradication Therapy in Helicobacter pylori Infection be Predicted? |
| title_full_unstemmed | Can the Response to Eradication Therapy in Helicobacter pylori Infection be Predicted? |
| title_short | Can the Response to Eradication Therapy in Helicobacter pylori Infection be Predicted? |
| title_sort | can the response to eradication therapy in helicobacter pylori infection be predicted |
| url | http://dx.doi.org/10.1155/2003/585862 |
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