Chondroitin Sulfate-Based Imatinib Nanoparticles Targeting Activated Hepatic Stellate Cells Against Hepatic Fibrosis

Chondroitin Sulfate-Based Imatinib Nanoparticles Targeting Activated Hepatic Stellate Cells Against Hepatic Fibrosis

<b>Background</b>: Activated hepatic stellate cells (aHSCs) play a significant role during the onset of hepatic fibrosis, ultimately leading to excessive deposition of extracellular matrix (ECM) and other typical pathological features, and thus have become a popular target for the treatm...

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Bibliographic Details
Main Authors: Xunzhi Liu, Changlong Fang, Hongling Yu, Lu Huang, Jiaxing Feng, Shiqin Luo, Li Song, Mengying Wu, Yulu Tan, Jianxia Dong, Tao Gong, Peihong Xiao
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Pharmaceutics
Subjects:
1-hexadecamine modified chondroitin sulfate
CD44 receptors
activated hepatic stellate cells
liver fibrosis
imatinib
Online Access:https://www.mdpi.com/1999-4923/17/3/351
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