In Vivo Assessment of Stem Cells for Treating Neurodegenerative Disease: Current Approaches and Future Prospects
In recent years, stem cell-related therapies have been widely applied for treating neurodegenerative disease. Despite their potential, stem cell tracking and imaging techniques for the evaluation of in vivo proof-of-concept (PoC) therapies have not been sufficiently represented in the research area....
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/9751583 |
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| _version_ | 1849686659769040896 |
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| author | Byeong-Wook Song |
| author_facet | Byeong-Wook Song |
| author_sort | Byeong-Wook Song |
| collection | DOAJ |
| description | In recent years, stem cell-related therapies have been widely applied for treating neurodegenerative disease. Despite their potential, stem cell tracking and imaging techniques for the evaluation of in vivo proof-of-concept (PoC) therapies have not been sufficiently represented in the research area. This review summarizes the recent approaches that have been used for tracking and imaging engrafted stem cells in vivo. Furthermore, we introduce tissue clearing technology that can be applied to develop three-dimensional in vivo experiments. Monitoring stem cell survival and migration and graft-host relationships is a useful strategy to evaluate the therapeutic efficacy of regenerative medicine approaches in neurodegenerative disease. |
| format | Article |
| id | doaj-art-b9e1bfc2ff0a4e5ca76d9155d48f99e3 |
| institution | DOAJ |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-b9e1bfc2ff0a4e5ca76d9155d48f99e32025-08-20T03:22:38ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/97515839751583In Vivo Assessment of Stem Cells for Treating Neurodegenerative Disease: Current Approaches and Future ProspectsByeong-Wook Song0EIT/LOFUS R&D Center, Institute for Integrative Medicine, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwon-do 25601, Republic of KoreaIn recent years, stem cell-related therapies have been widely applied for treating neurodegenerative disease. Despite their potential, stem cell tracking and imaging techniques for the evaluation of in vivo proof-of-concept (PoC) therapies have not been sufficiently represented in the research area. This review summarizes the recent approaches that have been used for tracking and imaging engrafted stem cells in vivo. Furthermore, we introduce tissue clearing technology that can be applied to develop three-dimensional in vivo experiments. Monitoring stem cell survival and migration and graft-host relationships is a useful strategy to evaluate the therapeutic efficacy of regenerative medicine approaches in neurodegenerative disease.http://dx.doi.org/10.1155/2017/9751583 |
| spellingShingle | Byeong-Wook Song In Vivo Assessment of Stem Cells for Treating Neurodegenerative Disease: Current Approaches and Future Prospects Stem Cells International |
| title | In Vivo Assessment of Stem Cells for Treating Neurodegenerative Disease: Current Approaches and Future Prospects |
| title_full | In Vivo Assessment of Stem Cells for Treating Neurodegenerative Disease: Current Approaches and Future Prospects |
| title_fullStr | In Vivo Assessment of Stem Cells for Treating Neurodegenerative Disease: Current Approaches and Future Prospects |
| title_full_unstemmed | In Vivo Assessment of Stem Cells for Treating Neurodegenerative Disease: Current Approaches and Future Prospects |
| title_short | In Vivo Assessment of Stem Cells for Treating Neurodegenerative Disease: Current Approaches and Future Prospects |
| title_sort | in vivo assessment of stem cells for treating neurodegenerative disease current approaches and future prospects |
| url | http://dx.doi.org/10.1155/2017/9751583 |
| work_keys_str_mv | AT byeongwooksong invivoassessmentofstemcellsfortreatingneurodegenerativediseasecurrentapproachesandfutureprospects |