Across ancestries, HLA-B∗08:01∼DRB1∗03:01 (DR3) and HLA-DQA∗01:02 (DR2) increase the risk to develop juvenile-onset systemic lupus erythematosus through low complement C4 levels

Across ancestries, HLA-B∗08:01∼DRB1∗03:01 (DR3) and HLA-DQA∗01:02 (DR2) increase the risk to develop juvenile-onset systemic lupus erythematosus through low complement C4 levels

Objective: Systemic lupus erythematosus (SLE) is a systemic autoimmune/inflammatory disease with a strong genetic component. Genetic burden is higher in children when compared to patients with adult-onset SLE, contributing to earlier disease expression and more severe phenotypes. The human leukocyte...

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Main Authors: Yves Renaudineau, Amandine Charras, Valentina Natoli, Nicolas Congy-Jolivet, Sam Haldenby, Xuan Liu, Yongxiang Fang, Eve MD. Smith, Michael W. Beresford, Christian M. Hedrich, Carla Roberts, Eslam Al-Abadi, Kate Armon, Kathryn Bailey, Coziana Ciurtin, Janet Gardner-Medwin, Kirsty Haslam, Daniel P. Hawley, Alice Leahy, Valentina Leone, Flora McErlane, Gita Modgil, Clarissa Pilkington, Athimalaipet V. Ramanan, Satyapal Rangaraj, Phil Riley, Arani Sridhar
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Translational Autoimmunity
Subjects:
Lupus
Genetic
Juvenile-onset
SLE
HLA
Haplotype
Online Access:http://www.sciencedirect.com/science/article/pii/S2589909025000036
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