Updates on lung cancer screening for early detection
This review examines the current status and recent progress in lung cancer screening programs, focusing on low-dose computed tomography (LDCT) and emerging liquid biopsy technologies. In Korea, the National Lung Cancer Screening Program has shown promising results in reducing lung cancer mortality s...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Korean Association of Internal Medicine
2025-07-01
|
| Series: | The Korean Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://kjim.org/upload/kjim-2025-008.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849419471299543040 |
|---|---|
| author | Se Hyun Kwak Chi Young Kim Sang Hoon Lee Eun Young Kim Eun Hye Lee Yoon Soo Chang |
| author_facet | Se Hyun Kwak Chi Young Kim Sang Hoon Lee Eun Young Kim Eun Hye Lee Yoon Soo Chang |
| author_sort | Se Hyun Kwak |
| collection | DOAJ |
| description | This review examines the current status and recent progress in lung cancer screening programs, focusing on low-dose computed tomography (LDCT) and emerging liquid biopsy technologies. In Korea, the National Lung Cancer Screening Program has shown promising results in reducing lung cancer mortality since its implementation in 2019. This review discusses the LDCT screening in Korea, including reductions in short-term mortality, increased screening uptake, and enhanced smoking cessation rates. Results from major international trials, including the National Lung Screening Trial, Nederlands–Leuvens Longkanker Screenings Onderzoek trial, and Multicenter Italian Lung Detection studies, demonstrating the efficacy of LDCT in reducing lung cancer mortality, are reviewed. The potential of liquid biopsy as a complement to LDCT is explored, with a focus on multi-cancer early detection technologies. Notable advances include the Circulating Cell-free Genome Atlas study and the Galleri® test, which have shown promise in detecting cancer at early stages through blood-based screening. We also highlight the challenges and limitations of current screening methods, including the need to improve strategies for screening non-smokers and the importance of balancing benefits against risks. As lung cancer screening continues to advance, combining LDCT and liquid biopsy is anticipated to provide more comprehensive and effective early detection strategies. |
| format | Article |
| id | doaj-art-b9de0ed3b1ba431caf2a7e6c01ef7dd9 |
| institution | Kabale University |
| issn | 1226-3303 2005-6648 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj-art-b9de0ed3b1ba431caf2a7e6c01ef7dd92025-08-20T03:32:04ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482025-07-0140454655610.3904/kjim.2025.008171029Updates on lung cancer screening for early detectionSe Hyun Kwak0Chi Young Kim1Sang Hoon Lee2Eun Young Kim3Eun Hye Lee4Yoon Soo Chang5 Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea Department of Internal Medicine, Yonsei University College of Medicine, Seoul, KoreaThis review examines the current status and recent progress in lung cancer screening programs, focusing on low-dose computed tomography (LDCT) and emerging liquid biopsy technologies. In Korea, the National Lung Cancer Screening Program has shown promising results in reducing lung cancer mortality since its implementation in 2019. This review discusses the LDCT screening in Korea, including reductions in short-term mortality, increased screening uptake, and enhanced smoking cessation rates. Results from major international trials, including the National Lung Screening Trial, Nederlands–Leuvens Longkanker Screenings Onderzoek trial, and Multicenter Italian Lung Detection studies, demonstrating the efficacy of LDCT in reducing lung cancer mortality, are reviewed. The potential of liquid biopsy as a complement to LDCT is explored, with a focus on multi-cancer early detection technologies. Notable advances include the Circulating Cell-free Genome Atlas study and the Galleri® test, which have shown promise in detecting cancer at early stages through blood-based screening. We also highlight the challenges and limitations of current screening methods, including the need to improve strategies for screening non-smokers and the importance of balancing benefits against risks. As lung cancer screening continues to advance, combining LDCT and liquid biopsy is anticipated to provide more comprehensive and effective early detection strategies.http://kjim.org/upload/kjim-2025-008.pdflung cancer screeninglow-dose computed tomographyliquid biopsymulti-cancer early detectionnational lung cancer screening program |
| spellingShingle | Se Hyun Kwak Chi Young Kim Sang Hoon Lee Eun Young Kim Eun Hye Lee Yoon Soo Chang Updates on lung cancer screening for early detection The Korean Journal of Internal Medicine lung cancer screening low-dose computed tomography liquid biopsy multi-cancer early detection national lung cancer screening program |
| title | Updates on lung cancer screening for early detection |
| title_full | Updates on lung cancer screening for early detection |
| title_fullStr | Updates on lung cancer screening for early detection |
| title_full_unstemmed | Updates on lung cancer screening for early detection |
| title_short | Updates on lung cancer screening for early detection |
| title_sort | updates on lung cancer screening for early detection |
| topic | lung cancer screening low-dose computed tomography liquid biopsy multi-cancer early detection national lung cancer screening program |
| url | http://kjim.org/upload/kjim-2025-008.pdf |
| work_keys_str_mv | AT sehyunkwak updatesonlungcancerscreeningforearlydetection AT chiyoungkim updatesonlungcancerscreeningforearlydetection AT sanghoonlee updatesonlungcancerscreeningforearlydetection AT eunyoungkim updatesonlungcancerscreeningforearlydetection AT eunhyelee updatesonlungcancerscreeningforearlydetection AT yoonsoochang updatesonlungcancerscreeningforearlydetection |