It’s about TIME – Gal-9 as a potential immunotherapeutic target in pancreatic ductal adenocarcinoma

It’s about TIME – Gal-9 as a potential immunotherapeutic target in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, characterized by an extremely poor prognosis and limited therapeutic options. Central to the progression and immune evasion of PDAC is the tumor (immune) microenvironment (TIME), where immune checkpoint proteins suc...

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Bibliographic Details
Main Authors: Christin Knickmeier, Gaetan Aime Noubissi Nzeteu, Bernhard F. Gibbs, Frederik J. H. Hoogwater, Maarten W. Nijkamp, Maximilian Bockhorn, N. Helge Meyer
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
pancreatic ductal adenocarcinoma
tumor immune microenvironment
immunotherapy
immune checkpoints
galectin-9
myeloid-derived suppressor cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1495907/full
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