Differential Proneness to Obesity in Two Rat Strains with Diverse Immune Responses
Although obesity and metabolic syndrome (comprising at least three of the following traits—abdominal obesity, elevated blood pressure, triglycerides and glucose/insulin resistance, and reduced high-density lipoprotein cholesterol in serum) are known to impact immune system activity, these conditions...
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2025-05-01
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| author | Dina Tucović Aleksandra Popov Aleksandrov Dušanka Popović Anastasija Malešević Vesna Subota Emilija Brdarić Svetlana Soković Bajić Milica Živković Milena Kataranovski Ivana Mirkov Stanislava Stanojević Jelena Kulaš |
| author_facet | Dina Tucović Aleksandra Popov Aleksandrov Dušanka Popović Anastasija Malešević Vesna Subota Emilija Brdarić Svetlana Soković Bajić Milica Živković Milena Kataranovski Ivana Mirkov Stanislava Stanojević Jelena Kulaš |
| author_sort | Dina Tucović |
| collection | DOAJ |
| description | Although obesity and metabolic syndrome (comprising at least three of the following traits—abdominal obesity, elevated blood pressure, triglycerides and glucose/insulin resistance, and reduced high-density lipoprotein cholesterol in serum) are known to impact immune system activity, these conditions are often not considered when immune response characteristics are investigated in various rodent strains. In this work, metabolic syndrome indices are compared in 3 month-old (young) and 6 month-old (adult) rats of Dark Agouti (DA) and Albino Oxford (AO) strains, while parameters of coagulation, inflammation and oxidative stress were determined in young animals. Study reveals that both young and adult AO rats are obese, intolerant to glucose with higher levels of triglycerides and lower levels of high-density lipoprotein cholesterol when compared to age-matched DA rats. Parameters of coagulation, inflammation and oxidative stress that may contribute to the worsening of metabolic syndrome during aging are also higher in young AO rats. Metabolic syndrome observed in young and intensified in adult AO rats should be taken into consideration when analyzing alterations in immune reactivity during aging in this rat strain. |
| format | Article |
| id | doaj-art-b9d345ffbe9e4b49bca4eb256aa5453e |
| institution | OA Journals |
| issn | 2079-7737 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj-art-b9d345ffbe9e4b49bca4eb256aa5453e2025-08-20T02:33:40ZengMDPI AGBiology2079-77372025-05-0114555710.3390/biology14050557Differential Proneness to Obesity in Two Rat Strains with Diverse Immune ResponsesDina Tucović0Aleksandra Popov Aleksandrov1Dušanka Popović2Anastasija Malešević3Vesna Subota4Emilija Brdarić5Svetlana Soković Bajić6Milica Živković7Milena Kataranovski8Ivana Mirkov9Stanislava Stanojević10Jelena Kulaš11Immunotoxicology Group, Department of Ecology, Institute for Biological Research “Siniša Stanković”—National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, SerbiaImmunotoxicology Group, Department of Ecology, Institute for Biological Research “Siniša Stanković”—National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, SerbiaImmunotoxicology Group, Department of Ecology, Institute for Biological Research “Siniša Stanković”—National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, SerbiaImmunotoxicology Group, Department of Ecology, Institute for Biological Research “Siniša Stanković”—National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, SerbiaInstitute for Medical Biochemistry, Military Medical Academy, 11000 Belgrade, SerbiaGroup for Probiotics and Microbiota-Host Interaction, Department for Microbiology and Plant Biology, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, 11000 Belgrade, SerbiaGroup for Probiotics and Microbiota-Host Interaction, Department for Microbiology and Plant Biology, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, 11000 Belgrade, SerbiaGroup for Probiotics and Microbiota-Host Interaction, Department for Microbiology and Plant Biology, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, 11000 Belgrade, SerbiaImmunotoxicology Group, Department of Ecology, Institute for Biological Research “Siniša Stanković”—National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, SerbiaImmunotoxicology Group, Department of Ecology, Institute for Biological Research “Siniša Stanković”—National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, SerbiaImmunotoxicology Group, Department of Ecology, Institute for Biological Research “Siniša Stanković”—National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, SerbiaImmunotoxicology Group, Department of Ecology, Institute for Biological Research “Siniša Stanković”—National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, SerbiaAlthough obesity and metabolic syndrome (comprising at least three of the following traits—abdominal obesity, elevated blood pressure, triglycerides and glucose/insulin resistance, and reduced high-density lipoprotein cholesterol in serum) are known to impact immune system activity, these conditions are often not considered when immune response characteristics are investigated in various rodent strains. In this work, metabolic syndrome indices are compared in 3 month-old (young) and 6 month-old (adult) rats of Dark Agouti (DA) and Albino Oxford (AO) strains, while parameters of coagulation, inflammation and oxidative stress were determined in young animals. Study reveals that both young and adult AO rats are obese, intolerant to glucose with higher levels of triglycerides and lower levels of high-density lipoprotein cholesterol when compared to age-matched DA rats. Parameters of coagulation, inflammation and oxidative stress that may contribute to the worsening of metabolic syndrome during aging are also higher in young AO rats. Metabolic syndrome observed in young and intensified in adult AO rats should be taken into consideration when analyzing alterations in immune reactivity during aging in this rat strain.https://www.mdpi.com/2079-7737/14/5/557Dark Agouti (DA) rat strainAlbino Oxford (AO) rat strainobesitymetabolic syndromecoagulation parametersoxidative stress and inflammation |
| spellingShingle | Dina Tucović Aleksandra Popov Aleksandrov Dušanka Popović Anastasija Malešević Vesna Subota Emilija Brdarić Svetlana Soković Bajić Milica Živković Milena Kataranovski Ivana Mirkov Stanislava Stanojević Jelena Kulaš Differential Proneness to Obesity in Two Rat Strains with Diverse Immune Responses Biology Dark Agouti (DA) rat strain Albino Oxford (AO) rat strain obesity metabolic syndrome coagulation parameters oxidative stress and inflammation |
| title | Differential Proneness to Obesity in Two Rat Strains with Diverse Immune Responses |
| title_full | Differential Proneness to Obesity in Two Rat Strains with Diverse Immune Responses |
| title_fullStr | Differential Proneness to Obesity in Two Rat Strains with Diverse Immune Responses |
| title_full_unstemmed | Differential Proneness to Obesity in Two Rat Strains with Diverse Immune Responses |
| title_short | Differential Proneness to Obesity in Two Rat Strains with Diverse Immune Responses |
| title_sort | differential proneness to obesity in two rat strains with diverse immune responses |
| topic | Dark Agouti (DA) rat strain Albino Oxford (AO) rat strain obesity metabolic syndrome coagulation parameters oxidative stress and inflammation |
| url | https://www.mdpi.com/2079-7737/14/5/557 |
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