The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes.
<h4>Background</h4>Genetic and biological evidence supports a role for DISC1 across a spectrum of major mental illnesses, including schizophrenia and bipolar disorder. There is evidence for genetic interplay between variants in DISC1 and in biologically interacting loci in psychiatric il...
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| Format: | Article |
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Public Library of Science (PLoS)
2009-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0004906&type=printable |
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| _version_ | 1849687129315082240 |
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| author | William Hennah David Porteous |
| author_facet | William Hennah David Porteous |
| author_sort | William Hennah |
| collection | DOAJ |
| description | <h4>Background</h4>Genetic and biological evidence supports a role for DISC1 across a spectrum of major mental illnesses, including schizophrenia and bipolar disorder. There is evidence for genetic interplay between variants in DISC1 and in biologically interacting loci in psychiatric illness. DISC1 also associates with normal variance in behavioral and brain imaging phenotypes.<h4>Methodology</h4>Here, we analyze public domain datasets and demonstrate correlations between variants in the DISC1 pathway genes and levels of gene expression. Genetic variants of DISC1, NDE1, PDE4B and PDE4D regulate the expression of cytoskeletal, synaptogenic, neurodevelopmental and sensory perception proteins. Interestingly, these regulated genes include existing targets for drug development in depression and psychosis.<h4>Conclusions</h4>Our systematic analysis provides further evidence for the relevance of the DISC1 pathway to major mental illness, identifies additional potential targets for therapeutic intervention and establishes a general strategy to mine public datasets for insights into disease pathways. |
| format | Article |
| id | doaj-art-b9ccdffdedec4cf381346e78bf7dcbfe |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-b9ccdffdedec4cf381346e78bf7dcbfe2025-08-20T03:22:26ZengPublic Library of Science (PLoS)PLoS ONE1932-62032009-01-0143e490610.1371/journal.pone.0004906The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes.William HennahDavid Porteous<h4>Background</h4>Genetic and biological evidence supports a role for DISC1 across a spectrum of major mental illnesses, including schizophrenia and bipolar disorder. There is evidence for genetic interplay between variants in DISC1 and in biologically interacting loci in psychiatric illness. DISC1 also associates with normal variance in behavioral and brain imaging phenotypes.<h4>Methodology</h4>Here, we analyze public domain datasets and demonstrate correlations between variants in the DISC1 pathway genes and levels of gene expression. Genetic variants of DISC1, NDE1, PDE4B and PDE4D regulate the expression of cytoskeletal, synaptogenic, neurodevelopmental and sensory perception proteins. Interestingly, these regulated genes include existing targets for drug development in depression and psychosis.<h4>Conclusions</h4>Our systematic analysis provides further evidence for the relevance of the DISC1 pathway to major mental illness, identifies additional potential targets for therapeutic intervention and establishes a general strategy to mine public datasets for insights into disease pathways.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0004906&type=printable |
| spellingShingle | William Hennah David Porteous The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes. PLoS ONE |
| title | The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes. |
| title_full | The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes. |
| title_fullStr | The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes. |
| title_full_unstemmed | The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes. |
| title_short | The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes. |
| title_sort | disc1 pathway modulates expression of neurodevelopmental synaptogenic and sensory perception genes |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0004906&type=printable |
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