Specific Low/Endogenous Replication Stress Response Protects Genomic Stability via Controlled ROS Production in an Adaptive Way and Is Dysregulated in Transformed Cells

Specific Low/Endogenous Replication Stress Response Protects Genomic Stability via Controlled ROS Production in an Adaptive Way and Is Dysregulated in Transformed Cells

Cells are assaulted daily by stresses that jeopardize genome integrity. Primary human cells adapt their response to the intensity of replication stress (RS) in a diphasic manner: below a stress threshold, the canonical DNA damage response (cDDR) is not activated, but a noncanonical cellular response...

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Bibliographic Details
Main Author: Bernard S. Lopez
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
DNA damage response
ROS
replication stress
genetic instability
NF-κB
PARP1
Online Access:https://www.mdpi.com/2073-4409/14/15/1183
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