Associations between bioaerosols, lung function work-shift changes and inflammatory markers: A study of recycling workers
OBJECTIVES: We investigated associations between bioaerosol exposures and work-shift changes in lung function and inflammatory markers among recycling workers. METHODS: Inhalable dust was measured with personal samplers and analyzed for endotoxin, bacteria, and fungi (incubated at 25 °C and 37 °C) l...
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| Format: | Article |
| Language: | English |
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Nordic Association of Occupational Safety and Health (NOROSH)
2024-12-01
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| Series: | Scandinavian Journal of Work, Environment & Health |
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https://www.sjweh.fi/article/4187
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| author | Karoline Kærgaard Hansen Vivi Schlünssen Karin Broberg Kirsten Østergaard Margit W Frederiksen Torben Sigsgaard Anne Mette Madsen Henrik Albert Kolstad |
| author_facet | Karoline Kærgaard Hansen Vivi Schlünssen Karin Broberg Kirsten Østergaard Margit W Frederiksen Torben Sigsgaard Anne Mette Madsen Henrik Albert Kolstad |
| author_sort | Karoline Kærgaard Hansen |
| collection | DOAJ |
| description | OBJECTIVES: We investigated associations between bioaerosol exposures and work-shift changes in lung function and inflammatory markers among recycling workers. METHODS: Inhalable dust was measured with personal samplers and analyzed for endotoxin, bacteria, and fungi (incubated at 25 °C and 37 °C) levels. Lung function (FEV1, FVC) was measured before and after work-shifts and serum concentrations of inflammatory markers (CRP, SAA, CC16, IL1B, IL2, IL4, IL5, IL6, IL8, IL10, IL13, and TNF) after the shift. Associations were explored by linear mixed-effects models. RESULTS: We included 170 measurements from 88 production workers exposed to inhalable dust, endotoxin, bacteria, and fungi (25 °C and 37 °C) at geometric mean levels of 0.6 mg/m3, 10.7 EU/m3, 1.6×104 CFU/m3, 4.4×104 CFU/m3, and 103 CFU/m3, respectively, and 14 administrative workers exposed at 7-fold lower levels. No associations were observed between bioaerosol exposures and work-shift change in lung function. IL2, IL6, IL10, and TNF concentrations were positively associated with inhalable dust levels, SAA and IL6 with bacteria, CRP, SAA, IL8, and TNF with fungi (25 °C or 37 °C), with the latter being the only statistically significant finding (exp(β) 1.40, 95% confidence interval 1.01–1.96). CONCLUSIONS: This study of recycling workers exposed to bioaerosol levels generally below those of farmers and compost workers and above background levels did not indicate any acute effect on lung function. Several inflammatory markers tended to increase with exposure, suggesting a systemic effect. Future research should combine data from bioaerosol-exposed workers to uncover health risks that may form the basis for health-based occupational exposure limits. |
| format | Article |
| id | doaj-art-b9c83a5347e846a3a273ec771d56dcdf |
| institution | OA Journals |
| issn | 0355-3140 1795-990X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nordic Association of Occupational Safety and Health (NOROSH) |
| record_format | Article |
| series | Scandinavian Journal of Work, Environment & Health |
| spelling | doaj-art-b9c83a5347e846a3a273ec771d56dcdf2025-08-20T02:28:00ZengNordic Association of Occupational Safety and Health (NOROSH)Scandinavian Journal of Work, Environment & Health0355-31401795-990X2024-12-0150860261210.5271/sjweh.41874187Associations between bioaerosols, lung function work-shift changes and inflammatory markers: A study of recycling workersKaroline Kærgaard Hansen0Vivi Schlünssen1Karin Broberg2Kirsten Østergaard3Margit W Frederiksen4Torben Sigsgaard5Anne Mette Madsen6Henrik Albert Kolstad7Correspondence to: Karoline Kærgaard Hansen, Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.Correspondence to: Karoline Kærgaard Hansen, Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.Correspondence to: Karoline Kærgaard Hansen, Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.Correspondence to: Karoline Kærgaard Hansen, Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.Correspondence to: Karoline Kærgaard Hansen, Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.Correspondence to: Karoline Kærgaard Hansen, Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.Correspondence to: Karoline Kærgaard Hansen, Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.Correspondence to: Karoline Kærgaard Hansen, Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.OBJECTIVES: We investigated associations between bioaerosol exposures and work-shift changes in lung function and inflammatory markers among recycling workers. METHODS: Inhalable dust was measured with personal samplers and analyzed for endotoxin, bacteria, and fungi (incubated at 25 °C and 37 °C) levels. Lung function (FEV1, FVC) was measured before and after work-shifts and serum concentrations of inflammatory markers (CRP, SAA, CC16, IL1B, IL2, IL4, IL5, IL6, IL8, IL10, IL13, and TNF) after the shift. Associations were explored by linear mixed-effects models. RESULTS: We included 170 measurements from 88 production workers exposed to inhalable dust, endotoxin, bacteria, and fungi (25 °C and 37 °C) at geometric mean levels of 0.6 mg/m3, 10.7 EU/m3, 1.6×104 CFU/m3, 4.4×104 CFU/m3, and 103 CFU/m3, respectively, and 14 administrative workers exposed at 7-fold lower levels. No associations were observed between bioaerosol exposures and work-shift change in lung function. IL2, IL6, IL10, and TNF concentrations were positively associated with inhalable dust levels, SAA and IL6 with bacteria, CRP, SAA, IL8, and TNF with fungi (25 °C or 37 °C), with the latter being the only statistically significant finding (exp(β) 1.40, 95% confidence interval 1.01–1.96). CONCLUSIONS: This study of recycling workers exposed to bioaerosol levels generally below those of farmers and compost workers and above background levels did not indicate any acute effect on lung function. Several inflammatory markers tended to increase with exposure, suggesting a systemic effect. Future research should combine data from bioaerosol-exposed workers to uncover health risks that may form the basis for health-based occupational exposure limits. https://www.sjweh.fi/article/4187 endotoxinlung functionfungibacteriabioaerosolwork-shift changeinflammatory markerrecyclinginhalable dustdomestic waste |
| spellingShingle | Karoline Kærgaard Hansen Vivi Schlünssen Karin Broberg Kirsten Østergaard Margit W Frederiksen Torben Sigsgaard Anne Mette Madsen Henrik Albert Kolstad Associations between bioaerosols, lung function work-shift changes and inflammatory markers: A study of recycling workers Scandinavian Journal of Work, Environment & Health endotoxin lung function fungi bacteria bioaerosol work-shift change inflammatory marker recycling inhalable dust domestic waste |
| title | Associations between bioaerosols, lung function work-shift changes and inflammatory markers: A study of recycling workers |
| title_full | Associations between bioaerosols, lung function work-shift changes and inflammatory markers: A study of recycling workers |
| title_fullStr | Associations between bioaerosols, lung function work-shift changes and inflammatory markers: A study of recycling workers |
| title_full_unstemmed | Associations between bioaerosols, lung function work-shift changes and inflammatory markers: A study of recycling workers |
| title_short | Associations between bioaerosols, lung function work-shift changes and inflammatory markers: A study of recycling workers |
| title_sort | associations between bioaerosols lung function work shift changes and inflammatory markers a study of recycling workers |
| topic | endotoxin lung function fungi bacteria bioaerosol work-shift change inflammatory marker recycling inhalable dust domestic waste |
| url |
https://www.sjweh.fi/article/4187
|
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