Manufacturing Strategy for Multiwalled Carbon Nanotubes as a Biocompatible and Innovative Material
We investigated the relationship between differences in multiwalled carbon nanotubes (MWCNTs) and the biological responses they elicit in order to develop biocompatible MWCNTs. We exposed human bronchial epithelial (BEAS-2B) cells to two sizes and six grades of MWCNTs and measured the resulting cell...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Nanotechnology |
| Online Access: | http://dx.doi.org/10.1155/2012/937819 |
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| author | Hisao Haniu Naoto Saito Yoshikazu Matsuda Yuki Usui Kaoru Aoki Masayuki Shimizu Nobuhide Ogihara Kazuo Hara Seiji Takanashi Masanori Okamoto Koichi Nakamura Norio Ishigaki Tamotsu Tsukahara Hiroyuki Kato |
| author_facet | Hisao Haniu Naoto Saito Yoshikazu Matsuda Yuki Usui Kaoru Aoki Masayuki Shimizu Nobuhide Ogihara Kazuo Hara Seiji Takanashi Masanori Okamoto Koichi Nakamura Norio Ishigaki Tamotsu Tsukahara Hiroyuki Kato |
| author_sort | Hisao Haniu |
| collection | DOAJ |
| description | We investigated the relationship between differences in multiwalled carbon nanotubes (MWCNTs) and the biological responses they elicit in order to develop biocompatible MWCNTs. We exposed human bronchial epithelial (BEAS-2B) cells to two sizes and six grades of MWCNTs and measured the resulting cell viability, total reactive oxygen and/or nitrogen species (tROS/RNS) production, and cytokine secretion. Although differences in cellular tROS production were associated with differences in grades of MWCNTs, the graphitization temperature of MWCNTs apparently did not influence tROS production. However, cell viability was affected by MWCNT graphitization temperature and diameter. Moreover, cytokine secretion was apparently affected by treatment temperature, but not MWCNT diameter. We concluded that the highest temperature resulted in the most biocompatibility because impurities and carbon defects were removed from the MWCNTs. However, other mechanisms are possible. Therefore, it is important to optimize each type of MWCNT by monitoring biological responses that type elicits during the manufacturing stage for applications involving biology and medicine. |
| format | Article |
| id | doaj-art-b9c77cc30ea74514ae2cc325d0a616a0 |
| institution | Kabale University |
| issn | 1687-9503 1687-9511 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nanotechnology |
| spelling | doaj-art-b9c77cc30ea74514ae2cc325d0a616a02025-02-03T06:13:07ZengWileyJournal of Nanotechnology1687-95031687-95112012-01-01201210.1155/2012/937819937819Manufacturing Strategy for Multiwalled Carbon Nanotubes as a Biocompatible and Innovative MaterialHisao Haniu0Naoto Saito1Yoshikazu Matsuda2Yuki Usui3Kaoru Aoki4Masayuki Shimizu5Nobuhide Ogihara6Kazuo Hara7Seiji Takanashi8Masanori Okamoto9Koichi Nakamura10Norio Ishigaki11Tamotsu Tsukahara12Hiroyuki Kato13Institute of Carbon Science and Technology, Shinshu University, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, JapanDepartment of Applied Physical Therapy, Shinshu University School of Health Sciences, Nagano 390-8621, JapanClinical Pharmacology Educational Center, Nihon Pharmaceutical University, Saitama 362-0806, JapanResearch Center for Exotic Nanocarbons, Shinshu University, Nagano 390-8621, JapanDepartment of Orthopaedic Surgery, Shinshu University School of Medicine, Nagano 390-8621, JapanDepartment of Orthopaedic Surgery, Shinshu University School of Medicine, Nagano 390-8621, JapanDepartment of Orthopaedic Surgery, Shinshu University School of Medicine, Nagano 390-8621, JapanDepartment of Orthopaedic Surgery, Shinshu University School of Medicine, Nagano 390-8621, JapanDepartment of Orthopaedic Surgery, Shinshu University School of Medicine, Nagano 390-8621, JapanDepartment of Orthopaedic Surgery, Shinshu University School of Medicine, Nagano 390-8621, JapanDepartment of Orthopaedic Surgery, Shinshu University School of Medicine, Nagano 390-8621, JapanDepartment of Orthopaedic Surgery, Shinshu University School of Medicine, Nagano 390-8621, JapanDepartment of Integrative Physiology and Bio-System Control, Shinshu University School of Medicine, Nagano 390-8621, JapanDepartment of Orthopaedic Surgery, Shinshu University School of Medicine, Nagano 390-8621, JapanWe investigated the relationship between differences in multiwalled carbon nanotubes (MWCNTs) and the biological responses they elicit in order to develop biocompatible MWCNTs. We exposed human bronchial epithelial (BEAS-2B) cells to two sizes and six grades of MWCNTs and measured the resulting cell viability, total reactive oxygen and/or nitrogen species (tROS/RNS) production, and cytokine secretion. Although differences in cellular tROS production were associated with differences in grades of MWCNTs, the graphitization temperature of MWCNTs apparently did not influence tROS production. However, cell viability was affected by MWCNT graphitization temperature and diameter. Moreover, cytokine secretion was apparently affected by treatment temperature, but not MWCNT diameter. We concluded that the highest temperature resulted in the most biocompatibility because impurities and carbon defects were removed from the MWCNTs. However, other mechanisms are possible. Therefore, it is important to optimize each type of MWCNT by monitoring biological responses that type elicits during the manufacturing stage for applications involving biology and medicine.http://dx.doi.org/10.1155/2012/937819 |
| spellingShingle | Hisao Haniu Naoto Saito Yoshikazu Matsuda Yuki Usui Kaoru Aoki Masayuki Shimizu Nobuhide Ogihara Kazuo Hara Seiji Takanashi Masanori Okamoto Koichi Nakamura Norio Ishigaki Tamotsu Tsukahara Hiroyuki Kato Manufacturing Strategy for Multiwalled Carbon Nanotubes as a Biocompatible and Innovative Material Journal of Nanotechnology |
| title | Manufacturing Strategy for Multiwalled Carbon Nanotubes as a Biocompatible and Innovative Material |
| title_full | Manufacturing Strategy for Multiwalled Carbon Nanotubes as a Biocompatible and Innovative Material |
| title_fullStr | Manufacturing Strategy for Multiwalled Carbon Nanotubes as a Biocompatible and Innovative Material |
| title_full_unstemmed | Manufacturing Strategy for Multiwalled Carbon Nanotubes as a Biocompatible and Innovative Material |
| title_short | Manufacturing Strategy for Multiwalled Carbon Nanotubes as a Biocompatible and Innovative Material |
| title_sort | manufacturing strategy for multiwalled carbon nanotubes as a biocompatible and innovative material |
| url | http://dx.doi.org/10.1155/2012/937819 |
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