Clinical and pathological features of patients with recurrent anti-glomerular basement membrane disease
Anti-glomerular basement membrane disease (anti-GBM disease) is a rare autoimmune disease, traditionally considered a monophasic autoimmune disorder, but more and more cases of recurrence have been reported. Through a review of the published literature and analysis of recurrent cases from our instit...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2502607 |
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| Summary: | Anti-glomerular basement membrane disease (anti-GBM disease) is a rare autoimmune disease, traditionally considered a monophasic autoimmune disorder, but more and more cases of recurrence have been reported. Through a review of the published literature and analysis of recurrent cases from our institution, we identified key predisposing factors including smoking (21.7%), hydrocarbon exposure (7.2%), prodromal infections (12.0%), and comorbid autoimmune conditions (12.0%). Notably, 43.5% (20/46) of recurrences occurred without identifiable triggers. There are not a few antibody-negative recurrences, challenging the reliability of serological monitoring alone for disease activity, and such recurrences may have an underlying unrecognized pathogenesis. Clinical presentations at recurrence varied: 38.6% of the patients had both lung and kidney involvement, 33.3% had lung involvement only, and 28.1% had kidney involvement only. Patients with concurrent systemic autoimmune diseases exhibited universally poor renal outcomes. |
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| ISSN: | 0886-022X 1525-6049 |