The actual approach of sentinel node biopsy in cutaneous melanoma
Sentinel lymph node biopsy (SLNB) is a well-established standard of care in melanoma treatment, but its role is evolving.Before the advent of modern systemic therapies, SLNB was critical in identifying which patients would benefit fromcomplementary lymphadenectomy and which would not require this pr...
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| Format: | Article |
| Language: | English |
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Via Medica
2025-01-01
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| Series: | Nowotwory |
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| Online Access: | https://journals.viamedica.pl/nowotwory_journal_of_oncology/article/view/104831 |
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| author | Maria Szymaniak Julia A. Janecka Wiktor Grabek Jan Radomski Kinga Flisiewicz-Wysocka Karolina Mizera Mateusz Wichtowski |
| author_facet | Maria Szymaniak Julia A. Janecka Wiktor Grabek Jan Radomski Kinga Flisiewicz-Wysocka Karolina Mizera Mateusz Wichtowski |
| author_sort | Maria Szymaniak |
| collection | DOAJ |
| description | Sentinel lymph node biopsy (SLNB) is a well-established standard of care in melanoma treatment, but its role is evolving.Before the advent of modern systemic therapies, SLNB was critical in identifying which patients would benefit fromcomplementary lymphadenectomy and which would not require this procedure. Currently, after a positive sentinel node biopsy, lymphadenectomy is no longer performed, altering the procedure’ssignificance. The SLNB identifies patients who will benefit from adjuvant treatment. Additionally, it enhances controlover locoregional lymphatic flow. As for now, there is no alternative to sentinel node biopsy. The gold standard for marking sentinel nodes in melanoma remains the dual radioisotope-dye method, using lymphoscintigraphyand SPECT-CT. There is ongoing research for new tracers that might replace this method, likely ferromagnetic tracers, which have shownnon-inferiority in breast cancer, have not yet proven to be of comparable value in melanoma, due to unpredictablelymphatic drainage, which required preoperative imaging. |
| format | Article |
| id | doaj-art-b9c40c55124545b2b09ccd05e0b64d26 |
| institution | Kabale University |
| issn | 0029-540X 2300-2115 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Via Medica |
| record_format | Article |
| series | Nowotwory |
| spelling | doaj-art-b9c40c55124545b2b09ccd05e0b64d262025-08-21T05:43:35ZengVia MedicaNowotwory0029-540X2300-21152025-01-0175310.5603/njo.104831The actual approach of sentinel node biopsy in cutaneous melanomaMaria Szymaniak0https://orcid.org/0009-0009-6497-7527Julia A. Janecka1https://orcid.org/0009-0005-9011-817XWiktor Grabek2https://orcid.org/0000-0002-9968-1955Jan Radomski3https://orcid.org/0000-0002-5931-7032Kinga Flisiewicz-Wysocka4https://orcid.org/0009-0004-5623-3871Karolina Mizera5https://orcid.org/0009-0000-7797-6333Mateusz Wichtowski6https://orcid.org/0000-0002-8507-2550Surgical Oncology Clinic, Institute of Oncology, Poznan University of Medical Sciences, PolandSurgical Oncology Clinic, Institute of Oncology, Poznan University of Medical Sciences, PolandSurgical Oncology Clinic, Institute of Oncology, Poznan University of Medical Sciences, PolandSurgical Oncology Clinic, Institute of Oncology, Poznan University of Medical Sciences, PolandSurgical Oncology Clinic, Institute of Oncology, Poznan University of Medical Sciences, PolandSurgical Oncology Clinic, Institute of Oncology, Poznan University of Medical Sciences, PolandSurgical Oncology Clinic, Institute of Oncology, Poznan University of Medical Sciences, PolandSentinel lymph node biopsy (SLNB) is a well-established standard of care in melanoma treatment, but its role is evolving.Before the advent of modern systemic therapies, SLNB was critical in identifying which patients would benefit fromcomplementary lymphadenectomy and which would not require this procedure. Currently, after a positive sentinel node biopsy, lymphadenectomy is no longer performed, altering the procedure’ssignificance. The SLNB identifies patients who will benefit from adjuvant treatment. Additionally, it enhances controlover locoregional lymphatic flow. As for now, there is no alternative to sentinel node biopsy. The gold standard for marking sentinel nodes in melanoma remains the dual radioisotope-dye method, using lymphoscintigraphyand SPECT-CT. There is ongoing research for new tracers that might replace this method, likely ferromagnetic tracers, which have shownnon-inferiority in breast cancer, have not yet proven to be of comparable value in melanoma, due to unpredictablelymphatic drainage, which required preoperative imaging.https://journals.viamedica.pl/nowotwory_journal_of_oncology/article/view/104831sentinel node biopsytracersferromagneticradioisotope |
| spellingShingle | Maria Szymaniak Julia A. Janecka Wiktor Grabek Jan Radomski Kinga Flisiewicz-Wysocka Karolina Mizera Mateusz Wichtowski The actual approach of sentinel node biopsy in cutaneous melanoma Nowotwory sentinel node biopsy tracers ferromagnetic radioisotope |
| title | The actual approach of sentinel node biopsy in cutaneous melanoma |
| title_full | The actual approach of sentinel node biopsy in cutaneous melanoma |
| title_fullStr | The actual approach of sentinel node biopsy in cutaneous melanoma |
| title_full_unstemmed | The actual approach of sentinel node biopsy in cutaneous melanoma |
| title_short | The actual approach of sentinel node biopsy in cutaneous melanoma |
| title_sort | actual approach of sentinel node biopsy in cutaneous melanoma |
| topic | sentinel node biopsy tracers ferromagnetic radioisotope |
| url | https://journals.viamedica.pl/nowotwory_journal_of_oncology/article/view/104831 |
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