Tau aggregation induces cell death in iPSC-derived neurons

Tau aggregation induces cell death in iPSC-derived neurons

Abnormal accumulation of tau proteins in the brain is a hallmark of neurodegenerative diseases such as Alzheimer’s disease and is closely linked with neuronal cell death. Tau accumulation is a prominent therapeutic target for Alzheimer’s disease, since tau accumulation correlates well with the disea...

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Bibliographic Details
Main Authors: Hirokazu Tanabe, Sumihiro Maeda, Etsuko Sano, Norio Sakai, Setsu Endoh-Yamagami, Hideyuki Okano
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Aging Brain
Subjects:
Tau
iPSC
Neuronal cell death
Aggregation
Overexpression
Online Access:http://www.sciencedirect.com/science/article/pii/S2589958925000027
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