Insights into the unique roles of extracellular vesicles for gut health modulation: Mechanisms, challenges, and perspectives
Extracellular vesicles (EVs), which play significant regulatory roles in maintaining homeostasis and influencing immune responses, significantly impact gut microbiota composition and function, affecting overall gut health. Despite considerable progress, there are still knowledge gaps regarding the m...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Current Research in Microbial Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666517424000841 |
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| author | Qiming Wu Juntao Kan Caili Fu Xin Liu Zhengying Cui Sixu Wang Yi Le Zhanming Li Qin Liu Yuyu Zhang Jun Du |
| author_facet | Qiming Wu Juntao Kan Caili Fu Xin Liu Zhengying Cui Sixu Wang Yi Le Zhanming Li Qin Liu Yuyu Zhang Jun Du |
| author_sort | Qiming Wu |
| collection | DOAJ |
| description | Extracellular vesicles (EVs), which play significant regulatory roles in maintaining homeostasis and influencing immune responses, significantly impact gut microbiota composition and function, affecting overall gut health. Despite considerable progress, there are still knowledge gaps regarding the mechanisms by which EVs, including plant-derived EVs (PDEVs), animal-derived EVs (ADEVs), and microbiota-derived EVs (MDEVs), modulate gut health. This review delves into the roles and mechanisms of EVs from diverse sources in regulating gut health, focusing on their contributions to maintaining epithelial barrier integrity, facilitating tissue healing, eliciting immune responses, controlling pathogens, and shaping microbiota. We emphasize open challenges and future perspectives for harnessing EVs in the modulation of gut health to gain a deeper understanding of their roles and impact. Importantly, a comprehensive research framework is presented to steer future investigations into the roles and implications of EVs on gut health, facilitating a more profound comprehension of this emerging field. |
| format | Article |
| id | doaj-art-b9b29530eaac449eabbbd08162cfaa9d |
| institution | OA Journals |
| issn | 2666-5174 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Microbial Sciences |
| spelling | doaj-art-b9b29530eaac449eabbbd08162cfaa9d2025-08-20T02:19:55ZengElsevierCurrent Research in Microbial Sciences2666-51742024-01-01710030110.1016/j.crmicr.2024.100301Insights into the unique roles of extracellular vesicles for gut health modulation: Mechanisms, challenges, and perspectivesQiming Wu0Juntao Kan1Caili Fu2Xin Liu3Zhengying Cui4Sixu Wang5Yi Le6Zhanming Li7Qin Liu8Yuyu Zhang9Jun Du10Nutrilite Health Institute, Shanghai 200031, ChinaNutrilite Health Institute, Shanghai 200031, ChinaDepartment of Food Science and Technology, National University of Singapore Suzhou Research Institute, Suzhou 215123, ChinaDepartment of Food Science and Technology, National University of Singapore Suzhou Research Institute, Suzhou 215123, ChinaDepartment of Food Science and Technology, National University of Singapore Suzhou Research Institute, Suzhou 215123, ChinaDepartment of Food Science and Technology, National University of Singapore Suzhou Research Institute, Suzhou 215123, ChinaDepartment of Food Science and Technology, National University of Singapore Suzhou Research Institute, Suzhou 215123, ChinaDepartment of Food Quality and Safety, Jiangsu University of Science and Technology, Zhenjiang 212100, ChinaCentre for Chinese Medicine Drug Development Limited, Hong Kong Baptist University, 999077, Hong Kong Special Administrative Region of China; Corresponding authors.Key Laboratory of Geriatric Nutrition and Health, Beijing Technology and Business University, Beijing 100048, China; Corresponding authors.Nutrilite Health Institute, Shanghai 200031, China; Corresponding authors.Extracellular vesicles (EVs), which play significant regulatory roles in maintaining homeostasis and influencing immune responses, significantly impact gut microbiota composition and function, affecting overall gut health. Despite considerable progress, there are still knowledge gaps regarding the mechanisms by which EVs, including plant-derived EVs (PDEVs), animal-derived EVs (ADEVs), and microbiota-derived EVs (MDEVs), modulate gut health. This review delves into the roles and mechanisms of EVs from diverse sources in regulating gut health, focusing on their contributions to maintaining epithelial barrier integrity, facilitating tissue healing, eliciting immune responses, controlling pathogens, and shaping microbiota. We emphasize open challenges and future perspectives for harnessing EVs in the modulation of gut health to gain a deeper understanding of their roles and impact. Importantly, a comprehensive research framework is presented to steer future investigations into the roles and implications of EVs on gut health, facilitating a more profound comprehension of this emerging field.http://www.sciencedirect.com/science/article/pii/S2666517424000841Extracellular vesiclesGut healthGut barrierMicrobiotaImmune responses |
| spellingShingle | Qiming Wu Juntao Kan Caili Fu Xin Liu Zhengying Cui Sixu Wang Yi Le Zhanming Li Qin Liu Yuyu Zhang Jun Du Insights into the unique roles of extracellular vesicles for gut health modulation: Mechanisms, challenges, and perspectives Current Research in Microbial Sciences Extracellular vesicles Gut health Gut barrier Microbiota Immune responses |
| title | Insights into the unique roles of extracellular vesicles for gut health modulation: Mechanisms, challenges, and perspectives |
| title_full | Insights into the unique roles of extracellular vesicles for gut health modulation: Mechanisms, challenges, and perspectives |
| title_fullStr | Insights into the unique roles of extracellular vesicles for gut health modulation: Mechanisms, challenges, and perspectives |
| title_full_unstemmed | Insights into the unique roles of extracellular vesicles for gut health modulation: Mechanisms, challenges, and perspectives |
| title_short | Insights into the unique roles of extracellular vesicles for gut health modulation: Mechanisms, challenges, and perspectives |
| title_sort | insights into the unique roles of extracellular vesicles for gut health modulation mechanisms challenges and perspectives |
| topic | Extracellular vesicles Gut health Gut barrier Microbiota Immune responses |
| url | http://www.sciencedirect.com/science/article/pii/S2666517424000841 |
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