Pulmonary artery denervation by noninvasive stereotactic radiotherapy: a pilot study in swine models of pulmonary hypertension
Abstract Catheter-based pulmonary artery denervation (PADN) has achieved promising outcomes to treat pulmonary hypertension (PH). We herein present stereotactic body radiotherapy (SBRT) as a novel noninvasive approach for PADN. A single fraction of 15 Gy, 20 Gy or 25 Gy was delivered for PADN in a t...
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Nature Portfolio
2025-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-55933-8 |
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| author | Xingxing Cai Zhixing Wei Yichen Shen Li Qian Jing Cai Yuli Yang Runmin Chi Wei Wang Shunxuan Yu Keke Li Yudong Fei Cheng Li Yaqin Han Ming Liu Jianguo Zhang Dengbin Wang Mawei Jiang Yi-Gang Li |
| author_facet | Xingxing Cai Zhixing Wei Yichen Shen Li Qian Jing Cai Yuli Yang Runmin Chi Wei Wang Shunxuan Yu Keke Li Yudong Fei Cheng Li Yaqin Han Ming Liu Jianguo Zhang Dengbin Wang Mawei Jiang Yi-Gang Li |
| author_sort | Xingxing Cai |
| collection | DOAJ |
| description | Abstract Catheter-based pulmonary artery denervation (PADN) has achieved promising outcomes to treat pulmonary hypertension (PH). We herein present stereotactic body radiotherapy (SBRT) as a novel noninvasive approach for PADN. A single fraction of 15 Gy, 20 Gy or 25 Gy was delivered for PADN in a thromboxane A2 (TxA2) - induced acute PH swine model. We demonstrated that PADN by 20-Gy SBRT reduced mean pulmonary artery (PA) pressure during the TxA2 challenge. All SBRT dosages led to a deeper denervation area compared with radiofrequency ablation (RFA) and reduced sympathetic neural norepinephrine synthesis in the ablation zone. Probable radiation related side effects were mostly found in animals treated with 25-Gy. In subsequent monocrotaline-induced chronic PH animals, PADN by 20-Gy SBRT resulted in more significant improvement in pulmonary hemodynamics and PA remodeling in comparison to RFA. In summary, our findings suggest that appropriate SBRT scheme could balance the efficacy and safety for PADN, potentiating to be a novel strategy to treat PH. |
| format | Article |
| id | doaj-art-b9b085bdf842411785216fd3f1e2ff12 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-b9b085bdf842411785216fd3f1e2ff122025-01-12T12:29:44ZengNature PortfolioNature Communications2041-17232025-01-0116111310.1038/s41467-025-55933-8Pulmonary artery denervation by noninvasive stereotactic radiotherapy: a pilot study in swine models of pulmonary hypertensionXingxing Cai0Zhixing Wei1Yichen Shen2Li Qian3Jing Cai4Yuli Yang5Runmin Chi6Wei Wang7Shunxuan Yu8Keke Li9Yudong Fei10Cheng Li11Yaqin Han12Ming Liu13Jianguo Zhang14Dengbin Wang15Mawei Jiang16Yi-Gang Li17Department of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineDepartment of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineDepartment of Oncology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineDepartment of Pathology, Affiliated Hospital of Nantong UniversityDepartment of Radiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineDepartment of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineDepartment of Radiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineDepartment of Oncology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineDepartment of Oncology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineDepartment of Oncology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineDepartment of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineDepartment of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineDepartment of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineDepartment of Radiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineDepartment of Pathology, Affiliated Hospital of Nantong UniversityDepartment of Radiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineDepartment of Oncology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineDepartment of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineAbstract Catheter-based pulmonary artery denervation (PADN) has achieved promising outcomes to treat pulmonary hypertension (PH). We herein present stereotactic body radiotherapy (SBRT) as a novel noninvasive approach for PADN. A single fraction of 15 Gy, 20 Gy or 25 Gy was delivered for PADN in a thromboxane A2 (TxA2) - induced acute PH swine model. We demonstrated that PADN by 20-Gy SBRT reduced mean pulmonary artery (PA) pressure during the TxA2 challenge. All SBRT dosages led to a deeper denervation area compared with radiofrequency ablation (RFA) and reduced sympathetic neural norepinephrine synthesis in the ablation zone. Probable radiation related side effects were mostly found in animals treated with 25-Gy. In subsequent monocrotaline-induced chronic PH animals, PADN by 20-Gy SBRT resulted in more significant improvement in pulmonary hemodynamics and PA remodeling in comparison to RFA. In summary, our findings suggest that appropriate SBRT scheme could balance the efficacy and safety for PADN, potentiating to be a novel strategy to treat PH.https://doi.org/10.1038/s41467-025-55933-8 |
| spellingShingle | Xingxing Cai Zhixing Wei Yichen Shen Li Qian Jing Cai Yuli Yang Runmin Chi Wei Wang Shunxuan Yu Keke Li Yudong Fei Cheng Li Yaqin Han Ming Liu Jianguo Zhang Dengbin Wang Mawei Jiang Yi-Gang Li Pulmonary artery denervation by noninvasive stereotactic radiotherapy: a pilot study in swine models of pulmonary hypertension Nature Communications |
| title | Pulmonary artery denervation by noninvasive stereotactic radiotherapy: a pilot study in swine models of pulmonary hypertension |
| title_full | Pulmonary artery denervation by noninvasive stereotactic radiotherapy: a pilot study in swine models of pulmonary hypertension |
| title_fullStr | Pulmonary artery denervation by noninvasive stereotactic radiotherapy: a pilot study in swine models of pulmonary hypertension |
| title_full_unstemmed | Pulmonary artery denervation by noninvasive stereotactic radiotherapy: a pilot study in swine models of pulmonary hypertension |
| title_short | Pulmonary artery denervation by noninvasive stereotactic radiotherapy: a pilot study in swine models of pulmonary hypertension |
| title_sort | pulmonary artery denervation by noninvasive stereotactic radiotherapy a pilot study in swine models of pulmonary hypertension |
| url | https://doi.org/10.1038/s41467-025-55933-8 |
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