Children Are Not Little Adults
Coronavirus has caused a pandemic affecting both adults and children. Although mortality rates in adults are high, that in children has been low, with many children experiencing only mild disease. This article looks at the pathophysiologic mechanisms that may account for the differences observed in...
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2020-10-01
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| Series: | Pediatric Respirology and Critical Care Medicine |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/prcm.prcm_11_21 |
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| _version_ | 1849713828869177344 |
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| author | Anne Goh |
| author_facet | Anne Goh |
| author_sort | Anne Goh |
| collection | DOAJ |
| description | Coronavirus has caused a pandemic affecting both adults and children. Although mortality rates in adults are high, that in children has been low, with many children experiencing only mild disease. This article looks at the pathophysiologic mechanisms that may account for the differences observed in children, namely a strong immune response, a lower number of angiotensin-converting enzyme 2, and a lower inflammatory response. Though children in general have mild disease, there is a hyperinflammatory condition known as multisystem inflammatory syndrome, which is likely a postinfectious immunologic response, which is seen mainly in children and adolescents and not adults. |
| format | Article |
| id | doaj-art-b9a3e08bbf574d229360391d042d0970 |
| institution | DOAJ |
| issn | 2543-0343 2543-0351 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Pediatric Respirology and Critical Care Medicine |
| spelling | doaj-art-b9a3e08bbf574d229360391d042d09702025-08-20T03:13:51ZengWolters Kluwer Medknow PublicationsPediatric Respirology and Critical Care Medicine2543-03432543-03512020-10-0144515310.4103/prcm.prcm_11_21Children Are Not Little AdultsAnne GohCoronavirus has caused a pandemic affecting both adults and children. Although mortality rates in adults are high, that in children has been low, with many children experiencing only mild disease. This article looks at the pathophysiologic mechanisms that may account for the differences observed in children, namely a strong immune response, a lower number of angiotensin-converting enzyme 2, and a lower inflammatory response. Though children in general have mild disease, there is a hyperinflammatory condition known as multisystem inflammatory syndrome, which is likely a postinfectious immunologic response, which is seen mainly in children and adolescents and not adults.https://journals.lww.com/10.4103/prcm.prcm_11_21covid-19paediatricpathophysiologysars-cov-2 |
| spellingShingle | Anne Goh Children Are Not Little Adults Pediatric Respirology and Critical Care Medicine covid-19 paediatric pathophysiology sars-cov-2 |
| title | Children Are Not Little Adults |
| title_full | Children Are Not Little Adults |
| title_fullStr | Children Are Not Little Adults |
| title_full_unstemmed | Children Are Not Little Adults |
| title_short | Children Are Not Little Adults |
| title_sort | children are not little adults |
| topic | covid-19 paediatric pathophysiology sars-cov-2 |
| url | https://journals.lww.com/10.4103/prcm.prcm_11_21 |
| work_keys_str_mv | AT annegoh childrenarenotlittleadults |