Fabrication of a Polyglycolic Acid Porous Microneedle Array Patch Using the Nonsolvent Induced Phase Separation Method for Body Fluid Extraction
ABSTRACT Traditional blood sampling is essential for early diagnosis and subsequent analysis, but the methods using hypodermic needles are painful and burdensome. Recently, a minimally invasive approach utilizing porous microneedles has been developed and various porous microneedle array patches (MA...
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Wiley-VCH
2025-04-01
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| Series: | Nano Select |
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| Online Access: | https://doi.org/10.1002/nano.202400145 |
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| author | Heyi Jing Jongho Park Beomjoon Kim |
| author_facet | Heyi Jing Jongho Park Beomjoon Kim |
| author_sort | Heyi Jing |
| collection | DOAJ |
| description | ABSTRACT Traditional blood sampling is essential for early diagnosis and subsequent analysis, but the methods using hypodermic needles are painful and burdensome. Recently, a minimally invasive approach utilizing porous microneedles has been developed and various porous microneedle array patches (MAPs) composed of biodegradable polymers have been investigated. To address issues about low mechanical strength and liquid absorption with porous MAPs, we used polyglycolic acid (PGA) as it is a biodegradable and hydrophilic polymer with high mechanical properties. In this study, we established a nonsolvent‐induced phase separation (NIPS) method for the fabrication of PGA porous MAPs, as the porous MAPs can be fabricated by simply immersing the molds injected with PGA‐hexafluoro‐2‐propanol (HFIP) solution in nonsolvents. We achieved the maximum liquid absorption rate of 16 ± 8.2 × 10−2 µL/min per one microneedle using the PGA porous MAPs fabricated by using ethanol as nonsolvent and PGA concentration of 10% (w/w). Our study provides a comprehensive understanding of porous MAPs fabricated using PGA material as well as its characteristics regarding the structural and mechanical properties of PGA MAPs, with potential as a diagnostic device to substitute conventional hypodermic needles for interstitial fluid (ISF) sampling and diagnosis. |
| format | Article |
| id | doaj-art-b9883abecb5249d98b1dc0d8bf25b826 |
| institution | OA Journals |
| issn | 2688-4011 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Nano Select |
| spelling | doaj-art-b9883abecb5249d98b1dc0d8bf25b8262025-08-20T02:08:45ZengWiley-VCHNano Select2688-40112025-04-0164n/an/a10.1002/nano.202400145Fabrication of a Polyglycolic Acid Porous Microneedle Array Patch Using the Nonsolvent Induced Phase Separation Method for Body Fluid ExtractionHeyi Jing0Jongho Park1Beomjoon Kim2Department of Precision Engineering School of Engineering The University of Tokyo Tokyo JapanInstitute of Industrial Science The University of Tokyo Tokyo JapanInstitute of Industrial Science The University of Tokyo Tokyo JapanABSTRACT Traditional blood sampling is essential for early diagnosis and subsequent analysis, but the methods using hypodermic needles are painful and burdensome. Recently, a minimally invasive approach utilizing porous microneedles has been developed and various porous microneedle array patches (MAPs) composed of biodegradable polymers have been investigated. To address issues about low mechanical strength and liquid absorption with porous MAPs, we used polyglycolic acid (PGA) as it is a biodegradable and hydrophilic polymer with high mechanical properties. In this study, we established a nonsolvent‐induced phase separation (NIPS) method for the fabrication of PGA porous MAPs, as the porous MAPs can be fabricated by simply immersing the molds injected with PGA‐hexafluoro‐2‐propanol (HFIP) solution in nonsolvents. We achieved the maximum liquid absorption rate of 16 ± 8.2 × 10−2 µL/min per one microneedle using the PGA porous MAPs fabricated by using ethanol as nonsolvent and PGA concentration of 10% (w/w). Our study provides a comprehensive understanding of porous MAPs fabricated using PGA material as well as its characteristics regarding the structural and mechanical properties of PGA MAPs, with potential as a diagnostic device to substitute conventional hypodermic needles for interstitial fluid (ISF) sampling and diagnosis.https://doi.org/10.1002/nano.202400145interstitial fluid (ISF)microneedle array patch (MAP)phase separationporous microneedle (MN)sensing |
| spellingShingle | Heyi Jing Jongho Park Beomjoon Kim Fabrication of a Polyglycolic Acid Porous Microneedle Array Patch Using the Nonsolvent Induced Phase Separation Method for Body Fluid Extraction Nano Select interstitial fluid (ISF) microneedle array patch (MAP) phase separation porous microneedle (MN) sensing |
| title | Fabrication of a Polyglycolic Acid Porous Microneedle Array Patch Using the Nonsolvent Induced Phase Separation Method for Body Fluid Extraction |
| title_full | Fabrication of a Polyglycolic Acid Porous Microneedle Array Patch Using the Nonsolvent Induced Phase Separation Method for Body Fluid Extraction |
| title_fullStr | Fabrication of a Polyglycolic Acid Porous Microneedle Array Patch Using the Nonsolvent Induced Phase Separation Method for Body Fluid Extraction |
| title_full_unstemmed | Fabrication of a Polyglycolic Acid Porous Microneedle Array Patch Using the Nonsolvent Induced Phase Separation Method for Body Fluid Extraction |
| title_short | Fabrication of a Polyglycolic Acid Porous Microneedle Array Patch Using the Nonsolvent Induced Phase Separation Method for Body Fluid Extraction |
| title_sort | fabrication of a polyglycolic acid porous microneedle array patch using the nonsolvent induced phase separation method for body fluid extraction |
| topic | interstitial fluid (ISF) microneedle array patch (MAP) phase separation porous microneedle (MN) sensing |
| url | https://doi.org/10.1002/nano.202400145 |
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