The effect of immunomodulatory celecoxsib on the gene expression of inhibitory receptors in dendritic cells generated from monocyte cells
Abstract Autoimmune diseases are characterized by irregular immune responses that disrupt self-tolerance. This research explores the effects of the immunomodulatory drug celecoxib on the expression of immune checkpoint receptors in monocyte-derived dendritic cells (DCs). Key receptors, including CTL...
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BMC
2025-04-01
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| Series: | BMC Research Notes |
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| Online Access: | https://doi.org/10.1186/s13104-025-07226-y |
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| author | Vida Hashemi Behzad Baradaran Bahar Naseri Javad Masoumi Elham Baghbani Nazila Alizadeh Reza Shiri Haris Arezoo Hosseini |
| author_facet | Vida Hashemi Behzad Baradaran Bahar Naseri Javad Masoumi Elham Baghbani Nazila Alizadeh Reza Shiri Haris Arezoo Hosseini |
| author_sort | Vida Hashemi |
| collection | DOAJ |
| description | Abstract Autoimmune diseases are characterized by irregular immune responses that disrupt self-tolerance. This research explores the effects of the immunomodulatory drug celecoxib on the expression of immune checkpoint receptors in monocyte-derived dendritic cells (DCs). Key receptors, including CTLA-4, VISTA, BTLA, PDL-1, B7H7, and LAG3, play critical roles in initiating and regulating immune responses and maintaining self-tolerance. Previous studies have highlighted the significance of immune checkpoints in preventing autoimmune conditions, with animal research supporting their effectiveness in immunotherapy. Our findings demonstrate that the upregulation of immune checkpoint receptors can enhance the inhibitory functions of DCs, thereby promoting self-tolerance. As a result, tolerogenic DCs present a promising therapeutic avenue for treating autoimmune diseases. Although these results are promising, further trials are required to validate this approach before it can be applied clinically. This study underscores the potential of targeting immune checkpoint receptors as a therapeutic strategy for autoimmune disorders. |
| format | Article |
| id | doaj-art-b97f11d6562745de87952d12a2b03b97 |
| institution | OA Journals |
| issn | 1756-0500 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj-art-b97f11d6562745de87952d12a2b03b972025-08-20T02:24:26ZengBMCBMC Research Notes1756-05002025-04-011811710.1186/s13104-025-07226-yThe effect of immunomodulatory celecoxsib on the gene expression of inhibitory receptors in dendritic cells generated from monocyte cellsVida Hashemi0Behzad Baradaran1Bahar Naseri2Javad Masoumi3Elham Baghbani4Nazila Alizadeh5Reza Shiri Haris6Arezoo Hosseini7Department of Laboratory Science, Faculty of Medicine, Maragheh University of Medical SciencesImmunology Research Center, Tabriz University of Medical SciencesImmunology Research Center, Tabriz University of Medical SciencesImmunology Research Center, Tabriz University of Medical SciencesImmunology Research Center, Tabriz University of Medical SciencesImmunology Research Center, Tabriz University of Medical SciencesDepartment of Laboratory Science, Faculty of Medicine, Maragheh University of Medical SciencesDepartment of Immunology and Genetics, Faculty of Medicine, Urmia University of Medical SciencesAbstract Autoimmune diseases are characterized by irregular immune responses that disrupt self-tolerance. This research explores the effects of the immunomodulatory drug celecoxib on the expression of immune checkpoint receptors in monocyte-derived dendritic cells (DCs). Key receptors, including CTLA-4, VISTA, BTLA, PDL-1, B7H7, and LAG3, play critical roles in initiating and regulating immune responses and maintaining self-tolerance. Previous studies have highlighted the significance of immune checkpoints in preventing autoimmune conditions, with animal research supporting their effectiveness in immunotherapy. Our findings demonstrate that the upregulation of immune checkpoint receptors can enhance the inhibitory functions of DCs, thereby promoting self-tolerance. As a result, tolerogenic DCs present a promising therapeutic avenue for treating autoimmune diseases. Although these results are promising, further trials are required to validate this approach before it can be applied clinically. This study underscores the potential of targeting immune checkpoint receptors as a therapeutic strategy for autoimmune disorders.https://doi.org/10.1186/s13104-025-07226-yCelecoxibImmune checkpointTolerogenic dendritic cellAutoimmune diseases |
| spellingShingle | Vida Hashemi Behzad Baradaran Bahar Naseri Javad Masoumi Elham Baghbani Nazila Alizadeh Reza Shiri Haris Arezoo Hosseini The effect of immunomodulatory celecoxsib on the gene expression of inhibitory receptors in dendritic cells generated from monocyte cells BMC Research Notes Celecoxib Immune checkpoint Tolerogenic dendritic cell Autoimmune diseases |
| title | The effect of immunomodulatory celecoxsib on the gene expression of inhibitory receptors in dendritic cells generated from monocyte cells |
| title_full | The effect of immunomodulatory celecoxsib on the gene expression of inhibitory receptors in dendritic cells generated from monocyte cells |
| title_fullStr | The effect of immunomodulatory celecoxsib on the gene expression of inhibitory receptors in dendritic cells generated from monocyte cells |
| title_full_unstemmed | The effect of immunomodulatory celecoxsib on the gene expression of inhibitory receptors in dendritic cells generated from monocyte cells |
| title_short | The effect of immunomodulatory celecoxsib on the gene expression of inhibitory receptors in dendritic cells generated from monocyte cells |
| title_sort | effect of immunomodulatory celecoxsib on the gene expression of inhibitory receptors in dendritic cells generated from monocyte cells |
| topic | Celecoxib Immune checkpoint Tolerogenic dendritic cell Autoimmune diseases |
| url | https://doi.org/10.1186/s13104-025-07226-y |
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