High-selenium exposure is associated with modulation of serum lipid metabolism
At present, there is no consensus on the relationship between selenium (Se) exposure and human serum lipid metabolism. The etiological role of high-Se exposure in lipid markers, dyslipidemia, and nonalcoholic fatty liver (NAFLD) remains unclear. We used serum untargeted metabolomics analysis to eval...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325000132 |
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| author | Yong Tan Zixiong Zhang Jinru Yang Li Wang Guogen Sun Yishan Guo Ying Xiang Yi Zou Xiusheng Song Minglong Li Chuying Huang |
| author_facet | Yong Tan Zixiong Zhang Jinru Yang Li Wang Guogen Sun Yishan Guo Ying Xiang Yi Zou Xiusheng Song Minglong Li Chuying Huang |
| author_sort | Yong Tan |
| collection | DOAJ |
| description | At present, there is no consensus on the relationship between selenium (Se) exposure and human serum lipid metabolism. The etiological role of high-Se exposure in lipid markers, dyslipidemia, and nonalcoholic fatty liver (NAFLD) remains unclear. We used serum untargeted metabolomics analysis to evaluate whether high-Se exposure is cross-sectionally associated with lipid metabolism in adults from high-Se exposure area (n = 112) and control area (n = 101) in Hubei Province, China. An untargeted liquid chromatography/mass spectrometry (LC/MS)-based metabolomic analysis identified 144 differential pathways and yielded 204 differentially abundant metabolites, including 32 lipid metabolites associated with lipids profiles. To further explore the correlation between Se exposure and serum lipid metabolism, we measured serum levels of lipid profiles among all the people, including serum cholesterol (CHOL), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and apolipoprotein B (APOB). The average serum Se level of the high-Se exposure group was 537.18 μg/L, significantly higher than 72.98 μg/L in the control group (p < 0.0001). The measurement levels of serum TG, LDL-C, HDL-C, and APOB in the high-Se exposure group were 1.03 (0.76, 1.34) mmol/L, 2.25 ± 0.48 mmol/L, 1.12 ± 0.24 mmol/L, and 0.77 ± 0.15 g/L, respectively, while the control group were 1.13 (0.84, 1.80) mmol/L, 2.56 ± 0.61 mmol/L, 1.02 ± 0.22 mmol/L, and 0.83 ± 0.16 g/L, respectively (all p values <0.05). Correlation analysis showed a significant negative correlation between serum Se and CHOL (r = -0.201, p < 0.01), serum Se is also associated with metabolomics markers, the negative correlation includes glyceric acid and ect., the positive correlation includes phosphorylcholine and ect. Our study suggests that high-Se exposure is negatively associated with serum lipid profiles and decreases the risk of high-TC and HDL-C dyslipidemia. |
| format | Article |
| id | doaj-art-b97aab938a8e46788d35edaf92d3338a |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-b97aab938a8e46788d35edaf92d3338a2025-01-23T05:26:04ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117677High-selenium exposure is associated with modulation of serum lipid metabolismYong Tan0Zixiong Zhang1Jinru Yang2Li Wang3Guogen Sun4Yishan Guo5Ying Xiang6Yi Zou7Xiusheng Song8Minglong Li9Chuying Huang10Hubei Selenium and Human Health Institute, the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi 445000, China; Hubei Provincial Key Lab of Selenium Resources and Bioapplications, Enshi 445000, ChinaHubei Selenium and Human Health Institute, the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi 445000, China; Hubei Provincial Key Lab of Selenium Resources and Bioapplications, Enshi 445000, ChinaDepartment of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan 430071, ChinaDepartment of Dermatology, the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi 445000, ChinaHubei Selenium and Human Health Institute, the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi 445000, China; Hubei Provincial Key Lab of Selenium Resources and Bioapplications, Enshi 445000, ChinaDepartment of Cardiology, Binzhou Medical University Hospital, Binzhou 256600, ChinaHubei Selenium and Human Health Institute, the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi 445000, China; Hubei Provincial Key Lab of Selenium Resources and Bioapplications, Enshi 445000, ChinaHubei Selenium and Human Health Institute, the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi 445000, China; Hubei Provincial Key Lab of Selenium Resources and Bioapplications, Enshi 445000, ChinaHubei Selenium and Human Health Institute, the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi 445000, China; Hubei Provincial Key Lab of Selenium Resources and Bioapplications, Enshi 445000, ChinaSchool of Forestry and Horticulture, Hubei Minzu University, Enshi 445000, China; Corresponding author.Hubei Selenium and Human Health Institute, the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi 445000, China; Hubei Provincial Key Lab of Selenium Resources and Bioapplications, Enshi 445000, China; Corresponding author at: Hubei Selenium and Human Health Institute, the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi 445000, China.At present, there is no consensus on the relationship between selenium (Se) exposure and human serum lipid metabolism. The etiological role of high-Se exposure in lipid markers, dyslipidemia, and nonalcoholic fatty liver (NAFLD) remains unclear. We used serum untargeted metabolomics analysis to evaluate whether high-Se exposure is cross-sectionally associated with lipid metabolism in adults from high-Se exposure area (n = 112) and control area (n = 101) in Hubei Province, China. An untargeted liquid chromatography/mass spectrometry (LC/MS)-based metabolomic analysis identified 144 differential pathways and yielded 204 differentially abundant metabolites, including 32 lipid metabolites associated with lipids profiles. To further explore the correlation between Se exposure and serum lipid metabolism, we measured serum levels of lipid profiles among all the people, including serum cholesterol (CHOL), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and apolipoprotein B (APOB). The average serum Se level of the high-Se exposure group was 537.18 μg/L, significantly higher than 72.98 μg/L in the control group (p < 0.0001). The measurement levels of serum TG, LDL-C, HDL-C, and APOB in the high-Se exposure group were 1.03 (0.76, 1.34) mmol/L, 2.25 ± 0.48 mmol/L, 1.12 ± 0.24 mmol/L, and 0.77 ± 0.15 g/L, respectively, while the control group were 1.13 (0.84, 1.80) mmol/L, 2.56 ± 0.61 mmol/L, 1.02 ± 0.22 mmol/L, and 0.83 ± 0.16 g/L, respectively (all p values <0.05). Correlation analysis showed a significant negative correlation between serum Se and CHOL (r = -0.201, p < 0.01), serum Se is also associated with metabolomics markers, the negative correlation includes glyceric acid and ect., the positive correlation includes phosphorylcholine and ect. Our study suggests that high-Se exposure is negatively associated with serum lipid profiles and decreases the risk of high-TC and HDL-C dyslipidemia.http://www.sciencedirect.com/science/article/pii/S0147651325000132High-Se exposureCHOLHDL-CLDL-CAPOB |
| spellingShingle | Yong Tan Zixiong Zhang Jinru Yang Li Wang Guogen Sun Yishan Guo Ying Xiang Yi Zou Xiusheng Song Minglong Li Chuying Huang High-selenium exposure is associated with modulation of serum lipid metabolism Ecotoxicology and Environmental Safety High-Se exposure CHOL HDL-C LDL-C APOB |
| title | High-selenium exposure is associated with modulation of serum lipid metabolism |
| title_full | High-selenium exposure is associated with modulation of serum lipid metabolism |
| title_fullStr | High-selenium exposure is associated with modulation of serum lipid metabolism |
| title_full_unstemmed | High-selenium exposure is associated with modulation of serum lipid metabolism |
| title_short | High-selenium exposure is associated with modulation of serum lipid metabolism |
| title_sort | high selenium exposure is associated with modulation of serum lipid metabolism |
| topic | High-Se exposure CHOL HDL-C LDL-C APOB |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325000132 |
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