Orexin system and pathogenesis of sleep-wake cycle disturbances in narcolepsy
Sleep is the one of the most important vital functions of the body. The study of the primary mechanisms that result in disturbance of the sleep-wake cycle is a priority of modern medical science. It is known that the orexin neurons of the hypothalamus, which send projections to all waking centers, p...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2018-01-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/1020 |
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| author | Yu. V. Gavrilov K. Z. Derevtsova H. A. Korneva |
| author_facet | Yu. V. Gavrilov K. Z. Derevtsova H. A. Korneva |
| author_sort | Yu. V. Gavrilov |
| collection | DOAJ |
| description | Sleep is the one of the most important vital functions of the body. The study of the primary mechanisms that result in disturbance of the sleep-wake cycle is a priority of modern medical science. It is known that the orexin neurons of the hypothalamus, which send projections to all waking centers, play a leading role in initiating and maintaining this state. Insufficiency of the function of the orexinergic system of the hypothalamus leads to disturbances in the sleep-wake cycle and the development of the severe diseases of narcolepsy and cataplexy. The presented review is devoted to the investigation of possible mechanisms of development of pathological changes in the orexin-containing neurons functions and the diseases caused by them. |
| format | Article |
| id | doaj-art-b97a97f7b19643f5b24990dfa5ef0fe6 |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-b97a97f7b19643f5b24990dfa5ef0fe62025-08-20T03:37:47ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842018-01-0116471510.20538/1682-0363-2017-4-7-15728Orexin system and pathogenesis of sleep-wake cycle disturbances in narcolepsyYu. V. Gavrilov0K. Z. Derevtsova1H. A. Korneva2Institute of Experimental Medicine (IEM)Institute of Experimental Medicine (IEM)Institute of Experimental Medicine (IEM); St.-Petersburg State UniversitySleep is the one of the most important vital functions of the body. The study of the primary mechanisms that result in disturbance of the sleep-wake cycle is a priority of modern medical science. It is known that the orexin neurons of the hypothalamus, which send projections to all waking centers, play a leading role in initiating and maintaining this state. Insufficiency of the function of the orexinergic system of the hypothalamus leads to disturbances in the sleep-wake cycle and the development of the severe diseases of narcolepsy and cataplexy. The presented review is devoted to the investigation of possible mechanisms of development of pathological changes in the orexin-containing neurons functions and the diseases caused by them.https://bulletin.ssmu.ru/jour/article/view/1020narcolepsycataplexyorexinsleepwakefulness |
| spellingShingle | Yu. V. Gavrilov K. Z. Derevtsova H. A. Korneva Orexin system and pathogenesis of sleep-wake cycle disturbances in narcolepsy Бюллетень сибирской медицины narcolepsy cataplexy orexin sleep wakefulness |
| title | Orexin system and pathogenesis of sleep-wake cycle disturbances in narcolepsy |
| title_full | Orexin system and pathogenesis of sleep-wake cycle disturbances in narcolepsy |
| title_fullStr | Orexin system and pathogenesis of sleep-wake cycle disturbances in narcolepsy |
| title_full_unstemmed | Orexin system and pathogenesis of sleep-wake cycle disturbances in narcolepsy |
| title_short | Orexin system and pathogenesis of sleep-wake cycle disturbances in narcolepsy |
| title_sort | orexin system and pathogenesis of sleep wake cycle disturbances in narcolepsy |
| topic | narcolepsy cataplexy orexin sleep wakefulness |
| url | https://bulletin.ssmu.ru/jour/article/view/1020 |
| work_keys_str_mv | AT yuvgavrilov orexinsystemandpathogenesisofsleepwakecycledisturbancesinnarcolepsy AT kzderevtsova orexinsystemandpathogenesisofsleepwakecycledisturbancesinnarcolepsy AT hakorneva orexinsystemandpathogenesisofsleepwakecycledisturbancesinnarcolepsy |