Aberrations of DNA methylation in cancer
DNA methylation is a chromatin modification that plays an important role in the epigenetic regulation of gene expression. Changes in DNA methylation patterns are characteristic of many malignant neoplasms. DNA methylation is occurred by DNA methyltransferases (DNMTs), while demethylation is mediated...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2022-12-01
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| Series: | Успехи молекулярной онкологии |
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| Online Access: | https://umo.abvpress.ru/jour/article/view/474 |
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| author | V. P. Maksimova O. G. Usalka Yu. V. Makus V. G. Popova E. S. Trapeznikova G. I. Khayrieva G. R. Sagitova E. M. Zhidkova A. Yu. Prus M. G. Yakubovskaya K. I. Kirsanov |
| author_facet | V. P. Maksimova O. G. Usalka Yu. V. Makus V. G. Popova E. S. Trapeznikova G. I. Khayrieva G. R. Sagitova E. M. Zhidkova A. Yu. Prus M. G. Yakubovskaya K. I. Kirsanov |
| author_sort | V. P. Maksimova |
| collection | DOAJ |
| description | DNA methylation is a chromatin modification that plays an important role in the epigenetic regulation of gene expression. Changes in DNA methylation patterns are characteristic of many malignant neoplasms. DNA methylation is occurred by DNA methyltransferases (DNMTs), while demethylation is mediated by TET family proteins. Mutations and changes in the expression profile of these enzymes lead to DNA hypo- and hypermethylation and have a strong impact on carcinogenesis. In this review, we considered the key aspects of the mechanisms of regulation of DNA methylation and demethylation, and also analyzed the role of DNA methyltransferases and TET family proteins in the pathogenesis of various malignant neoplasms.During the preparation of the review, we used the following biomedical literature information bases: Scopus (504), PubMed (553), Web of Science (1568), eLibrary (190). To obtain full-text documents, the electronic resources of PubMed Central (PMC), Science Direct, Research Gate, CyberLeninka were used. To analyze the mutational profile of epigenetic regulatory enzymes, we used the cBioportal portal (https://www.cbioportal.org / ), data from The AACR Project GENIE Consortium (https://www.mycancergenome.org / ), COSMIC, Clinvar, and The Cancer Genome Atlas (TCGA). |
| format | Article |
| id | doaj-art-b9752a90d9784db2905590a715b5eb36 |
| institution | Kabale University |
| issn | 2313-805X 2413-3787 |
| language | Russian |
| publishDate | 2022-12-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Успехи молекулярной онкологии |
| spelling | doaj-art-b9752a90d9784db2905590a715b5eb362025-08-20T03:38:02ZrusABV-pressУспехи молекулярной онкологии2313-805X2413-37872022-12-019410.17650/2313-805X-2022-9-4-24-40259Aberrations of DNA methylation in cancerV. P. Maksimova0O. G. Usalka1Yu. V. Makus2V. G. Popova3E. S. Trapeznikova4G. I. Khayrieva5G. R. Sagitova6E. M. Zhidkova7A. Yu. Prus8M. G. Yakubovskaya9K. I. Kirsanov10N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; Sechenov First Moscow State Medical University, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; Peoples’ Friendship University of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; Mendeleev University of Chemical Technology of RussiaSechenov First Moscow State Medical University, Ministry of Health of RussiaSechenov First Moscow State Medical University, Ministry of Health of RussiaSechenov First Moscow State Medical University, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; MIREA – Russian Technological UniversityN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; Peoples’ Friendship University of RussiaDNA methylation is a chromatin modification that plays an important role in the epigenetic regulation of gene expression. Changes in DNA methylation patterns are characteristic of many malignant neoplasms. DNA methylation is occurred by DNA methyltransferases (DNMTs), while demethylation is mediated by TET family proteins. Mutations and changes in the expression profile of these enzymes lead to DNA hypo- and hypermethylation and have a strong impact on carcinogenesis. In this review, we considered the key aspects of the mechanisms of regulation of DNA methylation and demethylation, and also analyzed the role of DNA methyltransferases and TET family proteins in the pathogenesis of various malignant neoplasms.During the preparation of the review, we used the following biomedical literature information bases: Scopus (504), PubMed (553), Web of Science (1568), eLibrary (190). To obtain full-text documents, the electronic resources of PubMed Central (PMC), Science Direct, Research Gate, CyberLeninka were used. To analyze the mutational profile of epigenetic regulatory enzymes, we used the cBioportal portal (https://www.cbioportal.org / ), data from The AACR Project GENIE Consortium (https://www.mycancergenome.org / ), COSMIC, Clinvar, and The Cancer Genome Atlas (TCGA).https://umo.abvpress.ru/jour/article/view/474epigenetic regulation of transcriptiononcogenesisdna methylationdna hydroxymethylationdna methyltransferasestet family proteinsmalignant tumors |
| spellingShingle | V. P. Maksimova O. G. Usalka Yu. V. Makus V. G. Popova E. S. Trapeznikova G. I. Khayrieva G. R. Sagitova E. M. Zhidkova A. Yu. Prus M. G. Yakubovskaya K. I. Kirsanov Aberrations of DNA methylation in cancer Успехи молекулярной онкологии epigenetic regulation of transcription oncogenesis dna methylation dna hydroxymethylation dna methyltransferases tet family proteins malignant tumors |
| title | Aberrations of DNA methylation in cancer |
| title_full | Aberrations of DNA methylation in cancer |
| title_fullStr | Aberrations of DNA methylation in cancer |
| title_full_unstemmed | Aberrations of DNA methylation in cancer |
| title_short | Aberrations of DNA methylation in cancer |
| title_sort | aberrations of dna methylation in cancer |
| topic | epigenetic regulation of transcription oncogenesis dna methylation dna hydroxymethylation dna methyltransferases tet family proteins malignant tumors |
| url | https://umo.abvpress.ru/jour/article/view/474 |
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