scTCR-seq and HTS reveal a special novel TRBD2-TRBJ1 rearrangement in mammalian TRB CDR3 repertoire

scTCR-seq and HTS reveal a special novel TRBD2-TRBJ1 rearrangement in mammalian TRB CDR3 repertoire

Abstract Mammalian T cell receptor (TCR) beta-chain (TRB) V-D-J rearrangement mainly follows the “12/23 rule”, and the “D-J rearrangement preceding the V-(D-J) rearrangement”. Owing to the physical position of the D-J-C cluster in the TRB locus, the TRBD2 (D2) gene cannot directly perform inversiona...

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Bibliographic Details
Main Authors: Yingjie Wu, Fengli Wu, Jun Li, Hao Zhou, Long Ma, Xinsheng Yao
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Genomics
Subjects:
Inversional rearrangement of the reverse TRBV gene
CDR3 repertoire
TRBD2-TRBJ1 rearrangement
Single-cell TCR sequencing
High-throughput sequencing
Online Access:https://doi.org/10.1186/s12864-025-11506-z
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