WDR3 undergoes phase separation to mediate the therapeutic mechanism of Nilotinib against osteosarcoma

WDR3 undergoes phase separation to mediate the therapeutic mechanism of Nilotinib against osteosarcoma

Abstract Background Osteosarcoma is highly invasive with a poor prognosis. The phenomenon of liquid-liquid phase separation (LLPS) can promote the formation of biomolecules and participate in the tumor regulation mechanism. Therefore, mining prognostic markers related to LLPS could allow patients to...

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Bibliographic Details
Main Authors:	Minglei Li, Nan Li, Yuying Fan, Zhan Zhang, Long Zhou, Yifan Yu, Man Ni, Mingzi Tan, WanJie Huang, Tong Zhu
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Series:	Journal of Experimental & Clinical Cancer Research
Subjects:	Osteosarcoma Liquid-liquid phase separation Prognostic biomarker WDR3 Nilotinib IDR mutation
Online Access:	https://doi.org/10.1186/s13046-025-03456-x
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