CD4+CD25highCD127low Regulatory T Cells in Peripheral Blood Are Not an Independent Factor for Chronic Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation
Background. The therapeutic efficacy of allogeneic hemopoietic stem cell transplantation (HSCT) largely relies on the graft-versus-leukemia (GVL) effect. Uncontrolled graft-versus-host disease (GVHD) is a feared complication of HSCT. Regulatory T cells (Treg) are a subset of CD4+ T-helper cells beli...
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| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/606839 |
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| author | Jolanta B. Perz Selma Gürel Stefan O. Schonland Ute Hegenbart Anthony D. Ho Peter Dreger |
| author_facet | Jolanta B. Perz Selma Gürel Stefan O. Schonland Ute Hegenbart Anthony D. Ho Peter Dreger |
| author_sort | Jolanta B. Perz |
| collection | DOAJ |
| description | Background. The therapeutic efficacy of allogeneic hemopoietic stem cell transplantation (HSCT) largely relies on the graft-versus-leukemia (GVL) effect. Uncontrolled graft-versus-host disease (GVHD) is a feared complication of HSCT. Regulatory T cells (Treg) are a subset of CD4+ T-helper cells believed to maintain tolerance after HSCT. It remains unclear whether low peripheral blood Treg have an impact on the risk for acute (aGVHD) and chronic GVHD (cGVHD). Methods. In this paper we enumerated the CD4+CD25highCD127low Treg in the peripheral blood of 84 patients after at least 150 days from HSCT and in 20 healthy age-matched controls. Results. Although similar mean lymphocyte counts were found in patients and controls, CD3+CD4+ T-cell counts were significantly lower in patients. Patients also had significantly lower Treg percentages among lymphocytes as compared to controls. Patients with cGVHD had even higher percentages of Treg if compared to patients without cGVHD. In multivariate analysis, Treg percentages were not an independent factor for cGVHD. Conclusions. This paper did not show a relation between deficient peripheral blood Treg and cGVHD, therefore cGVHD does not seem to occur as a result of peripheral Treg paucity. |
| format | Article |
| id | doaj-art-b96f7012e2c34bc9abe46142d9fdaa8f |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-b96f7012e2c34bc9abe46142d9fdaa8f2025-02-03T07:25:27ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/606839606839CD4+CD25highCD127low Regulatory T Cells in Peripheral Blood Are Not an Independent Factor for Chronic Graft-versus-Host Disease after Allogeneic Stem Cell TransplantationJolanta B. Perz0Selma Gürel1Stefan O. Schonland2Ute Hegenbart3Anthony D. Ho4Peter Dreger5Department of Internal Medicine-Hematology, Oncology and Rheumatology, University Hospital Heidelberg, 69120 Heidelberg, GermanyDepartment of Internal Medicine-Hematology, Oncology and Rheumatology, University Hospital Heidelberg, 69120 Heidelberg, GermanyDepartment of Internal Medicine-Hematology, Oncology and Rheumatology, University Hospital Heidelberg, 69120 Heidelberg, GermanyDepartment of Internal Medicine-Hematology, Oncology and Rheumatology, University Hospital Heidelberg, 69120 Heidelberg, GermanyDepartment of Internal Medicine-Hematology, Oncology and Rheumatology, University Hospital Heidelberg, 69120 Heidelberg, GermanyDepartment of Internal Medicine-Hematology, Oncology and Rheumatology, University Hospital Heidelberg, 69120 Heidelberg, GermanyBackground. The therapeutic efficacy of allogeneic hemopoietic stem cell transplantation (HSCT) largely relies on the graft-versus-leukemia (GVL) effect. Uncontrolled graft-versus-host disease (GVHD) is a feared complication of HSCT. Regulatory T cells (Treg) are a subset of CD4+ T-helper cells believed to maintain tolerance after HSCT. It remains unclear whether low peripheral blood Treg have an impact on the risk for acute (aGVHD) and chronic GVHD (cGVHD). Methods. In this paper we enumerated the CD4+CD25highCD127low Treg in the peripheral blood of 84 patients after at least 150 days from HSCT and in 20 healthy age-matched controls. Results. Although similar mean lymphocyte counts were found in patients and controls, CD3+CD4+ T-cell counts were significantly lower in patients. Patients also had significantly lower Treg percentages among lymphocytes as compared to controls. Patients with cGVHD had even higher percentages of Treg if compared to patients without cGVHD. In multivariate analysis, Treg percentages were not an independent factor for cGVHD. Conclusions. This paper did not show a relation between deficient peripheral blood Treg and cGVHD, therefore cGVHD does not seem to occur as a result of peripheral Treg paucity.http://dx.doi.org/10.1100/2012/606839 |
| spellingShingle | Jolanta B. Perz Selma Gürel Stefan O. Schonland Ute Hegenbart Anthony D. Ho Peter Dreger CD4+CD25highCD127low Regulatory T Cells in Peripheral Blood Are Not an Independent Factor for Chronic Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation The Scientific World Journal |
| title | CD4+CD25highCD127low Regulatory T Cells in Peripheral Blood Are Not an Independent Factor for Chronic Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation |
| title_full | CD4+CD25highCD127low Regulatory T Cells in Peripheral Blood Are Not an Independent Factor for Chronic Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation |
| title_fullStr | CD4+CD25highCD127low Regulatory T Cells in Peripheral Blood Are Not an Independent Factor for Chronic Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation |
| title_full_unstemmed | CD4+CD25highCD127low Regulatory T Cells in Peripheral Blood Are Not an Independent Factor for Chronic Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation |
| title_short | CD4+CD25highCD127low Regulatory T Cells in Peripheral Blood Are Not an Independent Factor for Chronic Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation |
| title_sort | cd4 cd25highcd127low regulatory t cells in peripheral blood are not an independent factor for chronic graft versus host disease after allogeneic stem cell transplantation |
| url | http://dx.doi.org/10.1100/2012/606839 |
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