Effects of supplementation of n-3 polyunsaturated fatty acids on renal functions in diabetes patients:a meta-analysis
Objective We performed a meta-analysis to systematically evaluate the impact of n-3 polyunsaturated fatty acids(n-3 PUFAs)supplementation on renal functions in diabetes patients,and to provide theoretical basis for chronic diabetic disease management.Methods We searched Pubmed,Cochrane Library,Embas...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2020-01-01
|
| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57906934&Fpath=home&index=0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849323509739683840 |
|---|---|
| author | ZHOU Qian-ying WU Qiong ZOU Qin CUI Yi |
| author_facet | ZHOU Qian-ying WU Qiong ZOU Qin CUI Yi |
| author_sort | ZHOU Qian-ying |
| collection | DOAJ |
| description | Objective We performed a meta-analysis to systematically evaluate the impact of n-3 polyunsaturated fatty acids(n-3 PUFAs)supplementation on renal functions in diabetes patients,and to provide theoretical basis for chronic diabetic disease management.Methods We searched Pubmed,Cochrane Library,Embase,and three major Chinese biomedical databases(CNKI,VIP and WANGFANG)for randomized controlled trials(RCTs)to examine the effects of n-3 PUFAs on renal function in diabetes patients,published before August 31,2018.Quality assessment and data extraction were performed,and RevMan 5.3 software was used for the Meta-analysis.Results We included 11 RCTs representing 614 patients with diabetes in this meta-analysis.The meta-analysis showed that,n-3 PUFAs supplementation significantly reduced urinary albumin excretion[MD=-2.65,95% CI(-4.67,-0.62),P=0.01]and serum creatinine level[MD=-2.60,95% CI(-4.98,-0.22),P=0.03],and delayed creatinine clearance decrease[MD=9.23,95% CI(4.37,14.09),P=0.0002].However,n-3 PUFAs supplementation failed to decrease urea nitrogen,uric acid and glomerular filtration rate.Conclusions In diabetes patients,n-3 PUFAs supplementation provides beneficial effects on urinary albumin excretion,serum creatinine and creatinine clearance,but has no obvious improvement effects on urea nitrogen,uric acid and glomerular filtration rate. |
| format | Article |
| id | doaj-art-b96f680f86ff497890ecfa2e9834039a |
| institution | Kabale University |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2020-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-b96f680f86ff497890ecfa2e9834039a2025-08-20T03:49:02ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902020-01-012045846457906934Effects of supplementation of n-3 polyunsaturated fatty acids on renal functions in diabetes patients:a meta-analysisZHOU Qian-yingWU QiongZOU QinCUI YiObjective We performed a meta-analysis to systematically evaluate the impact of n-3 polyunsaturated fatty acids(n-3 PUFAs)supplementation on renal functions in diabetes patients,and to provide theoretical basis for chronic diabetic disease management.Methods We searched Pubmed,Cochrane Library,Embase,and three major Chinese biomedical databases(CNKI,VIP and WANGFANG)for randomized controlled trials(RCTs)to examine the effects of n-3 PUFAs on renal function in diabetes patients,published before August 31,2018.Quality assessment and data extraction were performed,and RevMan 5.3 software was used for the Meta-analysis.Results We included 11 RCTs representing 614 patients with diabetes in this meta-analysis.The meta-analysis showed that,n-3 PUFAs supplementation significantly reduced urinary albumin excretion[MD=-2.65,95% CI(-4.67,-0.62),P=0.01]and serum creatinine level[MD=-2.60,95% CI(-4.98,-0.22),P=0.03],and delayed creatinine clearance decrease[MD=9.23,95% CI(4.37,14.09),P=0.0002].However,n-3 PUFAs supplementation failed to decrease urea nitrogen,uric acid and glomerular filtration rate.Conclusions In diabetes patients,n-3 PUFAs supplementation provides beneficial effects on urinary albumin excretion,serum creatinine and creatinine clearance,but has no obvious improvement effects on urea nitrogen,uric acid and glomerular filtration rate.http://www.lcszb.com/thesisDetails?columnId=57906934&Fpath=home&index=0n-3 polyunsaturated fatty acidsDiabetesRenal functionMeta-analysis |
| spellingShingle | ZHOU Qian-ying WU Qiong ZOU Qin CUI Yi Effects of supplementation of n-3 polyunsaturated fatty acids on renal functions in diabetes patients:a meta-analysis Linchuang shenzangbing zazhi n-3 polyunsaturated fatty acids Diabetes Renal function Meta-analysis |
| title | Effects of supplementation of n-3 polyunsaturated fatty acids on renal functions in diabetes patients:a meta-analysis |
| title_full | Effects of supplementation of n-3 polyunsaturated fatty acids on renal functions in diabetes patients:a meta-analysis |
| title_fullStr | Effects of supplementation of n-3 polyunsaturated fatty acids on renal functions in diabetes patients:a meta-analysis |
| title_full_unstemmed | Effects of supplementation of n-3 polyunsaturated fatty acids on renal functions in diabetes patients:a meta-analysis |
| title_short | Effects of supplementation of n-3 polyunsaturated fatty acids on renal functions in diabetes patients:a meta-analysis |
| title_sort | effects of supplementation of n 3 polyunsaturated fatty acids on renal functions in diabetes patients a meta analysis |
| topic | n-3 polyunsaturated fatty acids Diabetes Renal function Meta-analysis |
| url | http://www.lcszb.com/thesisDetails?columnId=57906934&Fpath=home&index=0 |
| work_keys_str_mv | AT zhouqianying effectsofsupplementationofn3polyunsaturatedfattyacidsonrenalfunctionsindiabetespatientsametaanalysis AT wuqiong effectsofsupplementationofn3polyunsaturatedfattyacidsonrenalfunctionsindiabetespatientsametaanalysis AT zouqin effectsofsupplementationofn3polyunsaturatedfattyacidsonrenalfunctionsindiabetespatientsametaanalysis AT cuiyi effectsofsupplementationofn3polyunsaturatedfattyacidsonrenalfunctionsindiabetespatientsametaanalysis |