A positive association of serum CCN5/WISP2 levels with the risk of developing gestational diabetes mellitus: a case–control study
Abstract Introduction CCN5/WISP2 is prominently manifest in adipose tissue and has been linked to the pathogenesis of obesity, diabetes, and insulin resistance. However, discrepancies exist in previous studies, and little is known about its association with gestational diabetes mellitus (GDM). The c...
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Elsevier
2023-10-01
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| Online Access: | https://doi.org/10.1186/s12576-023-00879-z |
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| author | Mohammed Farhan Hamdan Alshganbee Fariba Nabatchian Vida Farrokhi Reza Fadaei Nariman Moradi Reza Afrisham |
| author_facet | Mohammed Farhan Hamdan Alshganbee Fariba Nabatchian Vida Farrokhi Reza Fadaei Nariman Moradi Reza Afrisham |
| author_sort | Mohammed Farhan Hamdan Alshganbee |
| collection | DOAJ |
| description | Abstract Introduction CCN5/WISP2 is prominently manifest in adipose tissue and has been linked to the pathogenesis of obesity, diabetes, and insulin resistance. However, discrepancies exist in previous studies, and little is known about its association with gestational diabetes mellitus (GDM). The current investigation is designed to examine the correlation of WISP2 with risk factors in GDM patients in comparison to healthy pregnant women for the first time. Methods This case–control study measured serum levels of CCN5, TNF-α, IL-6, adiponectin, and fasting insulin using ELISA kits in 88 GDM patients and 88 pregnant women. Results The GDM group had remarkably higher serum levels of CCN5 (379.41 ± 83.078 ng/ml) compared to controls (212.02 ± 77.935 ng/ml). In a similar vein, it was observed that patients diagnosed with GDM exhibited elevated levels of pro-inflammatory cytokines such as IL-6 and TNF-α; while conversely, adiponectin levels were found to be significantly lower than those observed in the control group (P < 0.0001). In women with GDM, a positive and significant correlation was observed between CCN5 and BMI, FBG, insulin, HOMA-IR, as well as IL-6 and TNF-α levels. In the adjusted model, the risk of GDM was significantly increased with elevated serum CCN5 level. Conclusion Our research indicates a noteworthy and affirmative correlation between the levels of CCN5 in the serum and the risk of developing GDM, along with its associated risk factors such as BMI, insulin resistance index, FBG, and inflammatory cytokines (TNF-α and IL-6). These findings suggest that CCN5 could potentially play a role in the etiology of GDM. |
| format | Article |
| id | doaj-art-b96e41bf70f34d1f879cf1fae1288d5c |
| institution | DOAJ |
| issn | 1880-6562 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
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| series | Journal of Physiological Sciences |
| spelling | doaj-art-b96e41bf70f34d1f879cf1fae1288d5c2025-08-20T03:23:14ZengElsevierJournal of Physiological Sciences1880-65622023-10-017311710.1186/s12576-023-00879-zA positive association of serum CCN5/WISP2 levels with the risk of developing gestational diabetes mellitus: a case–control studyMohammed Farhan Hamdan Alshganbee0Fariba Nabatchian1Vida Farrokhi2Reza Fadaei3Nariman Moradi4Reza Afrisham5Department of Clinical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical SciencesDepartment of Clinical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical SciencesDepartment of Hematology, Faculty of Allied Medical Sciences, Tehran University of Medical SciencesSleep Disorders Research Center, Kermanshah University of Medical SciencesLiver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical SciencesDepartment of Clinical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical SciencesAbstract Introduction CCN5/WISP2 is prominently manifest in adipose tissue and has been linked to the pathogenesis of obesity, diabetes, and insulin resistance. However, discrepancies exist in previous studies, and little is known about its association with gestational diabetes mellitus (GDM). The current investigation is designed to examine the correlation of WISP2 with risk factors in GDM patients in comparison to healthy pregnant women for the first time. Methods This case–control study measured serum levels of CCN5, TNF-α, IL-6, adiponectin, and fasting insulin using ELISA kits in 88 GDM patients and 88 pregnant women. Results The GDM group had remarkably higher serum levels of CCN5 (379.41 ± 83.078 ng/ml) compared to controls (212.02 ± 77.935 ng/ml). In a similar vein, it was observed that patients diagnosed with GDM exhibited elevated levels of pro-inflammatory cytokines such as IL-6 and TNF-α; while conversely, adiponectin levels were found to be significantly lower than those observed in the control group (P < 0.0001). In women with GDM, a positive and significant correlation was observed between CCN5 and BMI, FBG, insulin, HOMA-IR, as well as IL-6 and TNF-α levels. In the adjusted model, the risk of GDM was significantly increased with elevated serum CCN5 level. Conclusion Our research indicates a noteworthy and affirmative correlation between the levels of CCN5 in the serum and the risk of developing GDM, along with its associated risk factors such as BMI, insulin resistance index, FBG, and inflammatory cytokines (TNF-α and IL-6). These findings suggest that CCN5 could potentially play a role in the etiology of GDM.https://doi.org/10.1186/s12576-023-00879-zCCN5/WISP2Gestational diabetes mellitusInflammationPregnancyWomen |
| spellingShingle | Mohammed Farhan Hamdan Alshganbee Fariba Nabatchian Vida Farrokhi Reza Fadaei Nariman Moradi Reza Afrisham A positive association of serum CCN5/WISP2 levels with the risk of developing gestational diabetes mellitus: a case–control study Journal of Physiological Sciences CCN5/WISP2 Gestational diabetes mellitus Inflammation Pregnancy Women |
| title | A positive association of serum CCN5/WISP2 levels with the risk of developing gestational diabetes mellitus: a case–control study |
| title_full | A positive association of serum CCN5/WISP2 levels with the risk of developing gestational diabetes mellitus: a case–control study |
| title_fullStr | A positive association of serum CCN5/WISP2 levels with the risk of developing gestational diabetes mellitus: a case–control study |
| title_full_unstemmed | A positive association of serum CCN5/WISP2 levels with the risk of developing gestational diabetes mellitus: a case–control study |
| title_short | A positive association of serum CCN5/WISP2 levels with the risk of developing gestational diabetes mellitus: a case–control study |
| title_sort | positive association of serum ccn5 wisp2 levels with the risk of developing gestational diabetes mellitus a case control study |
| topic | CCN5/WISP2 Gestational diabetes mellitus Inflammation Pregnancy Women |
| url | https://doi.org/10.1186/s12576-023-00879-z |
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