Diagnostic yield and safety of transbronchial lung cryobiopsy for diffuse parenchymal lung diseases diagnosis: Comparison between 1.7-mm and 1.9-mm probes
Purpose of the research: transbronchial lung cryobiopsy has been recently accepted as a valid and less invasive alternative to surgical lung biopsy. The purpose of this randomized controlled study was to evaluate, for the first time, the quality and safety of biopsy specimens obtained by using the n...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis
2025-12-01
|
| Series: | Pulmonology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1016/j.pulmoe.2023.04.003 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832592113227792384 |
|---|---|
| author | C. Ravaglia F. Sultani S. Piciucchi A. Dubini A. J. De Grauw S. Martinello S. Oldani S. Maitan F. Stella V. Poletti |
| author_facet | C. Ravaglia F. Sultani S. Piciucchi A. Dubini A. J. De Grauw S. Martinello S. Oldani S. Maitan F. Stella V. Poletti |
| author_sort | C. Ravaglia |
| collection | DOAJ |
| description | Purpose of the research: transbronchial lung cryobiopsy has been recently accepted as a valid and less invasive alternative to surgical lung biopsy. The purpose of this randomized controlled study was to evaluate, for the first time, the quality and safety of biopsy specimens obtained by using the new disposable 1.7-mm cryoprobe compared with the standard re-usable 1.9 mm cryoprobe in the diagnosis of diffuse parenchymal lung diseases. Methods: 60 consecutive patients were prospectively enrolled and randomly assigned to two different groups: 1.9 mm (group A) and 1.7 mm (group B); primary endpoints were pathological and multidisciplinary diagnostic yield, sample size and complication rate. Principal results: the pathological diagnostic yield of cryobiopsy was 100% in group A and 93.3% in group B (p = 0.718); cryobiopsy median diameter was 6.8 mm in group A and 6.7 mm in group B (p = 0,5241). Pneumothorax occurred in 9 patients in group A and 10 in group B (p = 0.951); mild-to-moderate bleeding in 7 cases and 9 cases in group A and B respectively (p = 0.559). No death or severe adverse events were observed. Conclusions: there was no statistically significant difference between the two groups, regarding diagnostic yield, adverse events and sampling adequacy. |
| format | Article |
| id | doaj-art-b9691ec120a44acf90139b38110c97d3 |
| institution | Kabale University |
| issn | 2531-0429 2531-0437 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis |
| record_format | Article |
| series | Pulmonology |
| spelling | doaj-art-b9691ec120a44acf90139b38110c97d32025-01-21T15:08:04ZengTaylor & FrancisPulmonology2531-04292531-04372025-12-0131110.1016/j.pulmoe.2023.04.003Diagnostic yield and safety of transbronchial lung cryobiopsy for diffuse parenchymal lung diseases diagnosis: Comparison between 1.7-mm and 1.9-mm probesC. Ravaglia0F. Sultani1S. Piciucchi2A. Dubini3A. J. De Grauw4S. Martinello5S. Oldani6S. Maitan7F. Stella8V. Poletti9Pulmonology Unit, G.B. Morgagni Hospital/University of Bologna, Forlì ItalyPulmonology Unit, G.B. Morgagni Hospital/University of Bologna, Forlì ItalyRadiology Unit, G.B. Morgagni Hospital/University of Bologna, Forlì ItalyPathology Unit, G.B. Morgagni Hospital/University of Bologna, Forlì ItalyPulmonology Unit, G.B. Morgagni Hospital/University of Bologna, Forlì ItalyPulmonology Unit, G.B. Morgagni Hospital/University of Bologna, Forlì ItalyPulmonology Unit, G.B. Morgagni Hospital/University of Bologna, Forlì ItalyAnesthesiology and Intensive Care Unit, G.B. Morgagni Hospital/University of Bologna, Forlì ItalyAlma Mater Studiorum University of Bologna, Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), Bologna, ItalyPulmonology Unit, G.B. Morgagni Hospital/University of Bologna, Forlì ItalyPurpose of the research: transbronchial lung cryobiopsy has been recently accepted as a valid and less invasive alternative to surgical lung biopsy. The purpose of this randomized controlled study was to evaluate, for the first time, the quality and safety of biopsy specimens obtained by using the new disposable 1.7-mm cryoprobe compared with the standard re-usable 1.9 mm cryoprobe in the diagnosis of diffuse parenchymal lung diseases. Methods: 60 consecutive patients were prospectively enrolled and randomly assigned to two different groups: 1.9 mm (group A) and 1.7 mm (group B); primary endpoints were pathological and multidisciplinary diagnostic yield, sample size and complication rate. Principal results: the pathological diagnostic yield of cryobiopsy was 100% in group A and 93.3% in group B (p = 0.718); cryobiopsy median diameter was 6.8 mm in group A and 6.7 mm in group B (p = 0,5241). Pneumothorax occurred in 9 patients in group A and 10 in group B (p = 0.951); mild-to-moderate bleeding in 7 cases and 9 cases in group A and B respectively (p = 0.559). No death or severe adverse events were observed. Conclusions: there was no statistically significant difference between the two groups, regarding diagnostic yield, adverse events and sampling adequacy.https://www.tandfonline.com/doi/10.1016/j.pulmoe.2023.04.003CryobiopsyProbe1.7 mm1.9 mmILDInterstitial lung |
| spellingShingle | C. Ravaglia F. Sultani S. Piciucchi A. Dubini A. J. De Grauw S. Martinello S. Oldani S. Maitan F. Stella V. Poletti Diagnostic yield and safety of transbronchial lung cryobiopsy for diffuse parenchymal lung diseases diagnosis: Comparison between 1.7-mm and 1.9-mm probes Pulmonology Cryobiopsy Probe 1.7 mm 1.9 mm ILD Interstitial lung |
| title | Diagnostic yield and safety of transbronchial lung cryobiopsy for diffuse parenchymal lung diseases diagnosis: Comparison between 1.7-mm and 1.9-mm probes |
| title_full | Diagnostic yield and safety of transbronchial lung cryobiopsy for diffuse parenchymal lung diseases diagnosis: Comparison between 1.7-mm and 1.9-mm probes |
| title_fullStr | Diagnostic yield and safety of transbronchial lung cryobiopsy for diffuse parenchymal lung diseases diagnosis: Comparison between 1.7-mm and 1.9-mm probes |
| title_full_unstemmed | Diagnostic yield and safety of transbronchial lung cryobiopsy for diffuse parenchymal lung diseases diagnosis: Comparison between 1.7-mm and 1.9-mm probes |
| title_short | Diagnostic yield and safety of transbronchial lung cryobiopsy for diffuse parenchymal lung diseases diagnosis: Comparison between 1.7-mm and 1.9-mm probes |
| title_sort | diagnostic yield and safety of transbronchial lung cryobiopsy for diffuse parenchymal lung diseases diagnosis comparison between 1 7 mm and 1 9 mm probes |
| topic | Cryobiopsy Probe 1.7 mm 1.9 mm ILD Interstitial lung |
| url | https://www.tandfonline.com/doi/10.1016/j.pulmoe.2023.04.003 |
| work_keys_str_mv | AT cravaglia diagnosticyieldandsafetyoftransbronchiallungcryobiopsyfordiffuseparenchymallungdiseasesdiagnosiscomparisonbetween17mmand19mmprobes AT fsultani diagnosticyieldandsafetyoftransbronchiallungcryobiopsyfordiffuseparenchymallungdiseasesdiagnosiscomparisonbetween17mmand19mmprobes AT spiciucchi diagnosticyieldandsafetyoftransbronchiallungcryobiopsyfordiffuseparenchymallungdiseasesdiagnosiscomparisonbetween17mmand19mmprobes AT adubini diagnosticyieldandsafetyoftransbronchiallungcryobiopsyfordiffuseparenchymallungdiseasesdiagnosiscomparisonbetween17mmand19mmprobes AT ajdegrauw diagnosticyieldandsafetyoftransbronchiallungcryobiopsyfordiffuseparenchymallungdiseasesdiagnosiscomparisonbetween17mmand19mmprobes AT smartinello diagnosticyieldandsafetyoftransbronchiallungcryobiopsyfordiffuseparenchymallungdiseasesdiagnosiscomparisonbetween17mmand19mmprobes AT soldani diagnosticyieldandsafetyoftransbronchiallungcryobiopsyfordiffuseparenchymallungdiseasesdiagnosiscomparisonbetween17mmand19mmprobes AT smaitan diagnosticyieldandsafetyoftransbronchiallungcryobiopsyfordiffuseparenchymallungdiseasesdiagnosiscomparisonbetween17mmand19mmprobes AT fstella diagnosticyieldandsafetyoftransbronchiallungcryobiopsyfordiffuseparenchymallungdiseasesdiagnosiscomparisonbetween17mmand19mmprobes AT vpoletti diagnosticyieldandsafetyoftransbronchiallungcryobiopsyfordiffuseparenchymallungdiseasesdiagnosiscomparisonbetween17mmand19mmprobes |