Synergistic therapy for pancreatic cancer by deactivating cancer-associated fibroblasts and driving T-cell migration into tumor microenvironment using nanochaperone delivery system

Synergistic therapy for pancreatic cancer by deactivating cancer-associated fibroblasts and driving T-cell migration into tumor microenvironment using nanochaperone delivery system

The success of immunotherapy in pancreatic ductal adenocarcinoma (PDAC) is greatly limited by the scarcity of cytotoxic T lymphocytes (CTLs) in tumor microenvironment, which is mainly due to the physical barrier formed by a dense extracellular matrix (ECM). Here we reported a potent strategy to rect...

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Bibliographic Details
Main Authors: Jiajing Chen, Feihe Ma, Yujie Chen, Mengchen Xu, Yongxin Zhang, Shuyu Wang, Hongyun Liu, Linlin Xu, Yang Liu, Rujiang Ma, Jinpu Yu, Linqi Shi
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-10-01
Series:Bioactive Materials
Subjects:
Pancreatic cancer
Chemokines
Cancer-associated fibroblasts
T cell migration
Nanochaperone
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X25002397
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